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Darunavir ethanolate

Darunavir ethanolate Structure
Darunavir ethanolate structure
CAS No.
635728-49-3
Chemical Name:
Darunavir ethanolate
Synonyms
Darunavir ethanolate;Carbamic acid, ((1S,2R)-3-(((4-aminophenyl)sulfonyl)(2-methylpropyl)amino)-2-hydroxy-1-(phenylmethyl)propyl)-, (3R,3as,6ar)-hexahydrofuro(2,3-B)furan-3-yl ester, compd. with ethanol (1:1);To the drug;Unii-33o78xf0bw;[14C]-Darunavir ethanolate;Darunavir Ethanolate (100 mg);Darunavir Ethanolate(Prezista);Darunavir hemiethanolate salt;Darunavir Ethanolate (DRV, Prezista);Darunavir(TMC-114,UIC 94017) Ethanolate
CBNumber:
CB32496602
Molecular Formula:
C29H43N3O8S
Molecular Weight:
593.74
MDL Number:
MFCD18251642
MOL File:
635728-49-3.mol
Last updated:2023-05-18 11:31:03
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Darunavir ethanolate Properties

Melting point 98-100°C
storage temp. Refrigerator
solubility Chloroform (Slightly), Methanol (Slightly)
form Solid
color White
FDA UNII 33O78XF0BW

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
HS Code  29334900

Darunavir ethanolate price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC D193520 DarunavirEthanolate 635728-49-3 5mg $150 2021-12-16 Buy
Usbiological 163597 Darunavir Ethanolate 635728-49-3 5mg $460 2021-12-16 Buy
TRC D193520 DarunavirEthanolate 635728-49-3 50mg $770 2021-12-16 Buy
ChemScene CS-0750 DarunavirEthanolate 99.92% 635728-49-3 100mg $500 2021-12-16 Buy
Biosynth Carbosynth FD64995 Darunavir Ethanolate 635728-49-3 500mg $175 2021-12-16 Buy
Product number Packaging Price Buy
D193520 5mg $150 Buy
163597 5mg $460 Buy
D193520 50mg $770 Buy
CS-0750 100mg $500 Buy
FD64995 500mg $175 Buy

Darunavir ethanolate Chemical Properties,Uses,Production

Uses

Darunavir Ethanolate (Prezista) is an HIV protease inhibitor. Derivative of Darunavir (D193500), a second generation HIV-1-protease inhibitor; structurally similar to amprenavir. Antiviral. It is a COVID19-related research product.

Uses

Darunavir Ethanolate(Prezista) is an inhibitor of HIV protease. [1] Darunavir was designed to form robust interactions with the protease enzyme from many strains of HIV, including strains from treatment-experienced patients with multiple resistance mutati

Biological Activity

darunavir ethanolate is a nonpeptidic hiv protease inhibitor approved for the treatment of hiv infection[1].transepithelial transport of darunavir in caco-2 cell monolayers is 2-fold greater in the basal-to-apical direction compared to that in the opposite direction. in l-mdr1 cell, darunavir (121 mm) inhibits p-glycoprotein-mediated efflux of calcein-acetoxymethyl ester[1].darunavir is effective against wild-type and pi-resistant hiv, and has a low oral bioavailability (37%). when used in combination with ritonavir, bioavailability can be increased to 82%[2].[1]. fujimoto h, higuchi m, watanabe h, et al. p-glycoprotein mediates efflux transport of darunavir in human intestinal caco-2 and abcb1 gene-transfected renal llc-pk1 cell lines. biological & pharmaceutical bulletin, 2009, 32(9): 1588-1593.[2]. bhalekar mr, et al. in-vivo bioavailability and lymphatic uptake evaluation of lipid nanoparticulates of darunavir. drug deliv, 2016, 23(7): 2581-2586.

Darunavir ethanolate synthesis

191226-98-9
635728-49-3
Synthesis of Darunavir ethanolate from tert-Butyl [(1S,2R)-1-benzyl-2-hydroxy-3-[isobutyl[(4-nitrophenyl)sulfonyl]amino]propyl]carbamate

Darunavir ethanolate Preparation Products And Raw materials

Raw materials

tert-Butyl [(1S,2R)-1-benzyl-2-hydroxy-3-[isobutyl[(4-nitrophenyl)sulfonyl]amino]propyl]carbamate (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl 4-nitrophenyl carbonate 4-AMINO-N-[(2R,3S)-3-AMINO-2-HYDROXY-4-PHENYLBUTYL]-N-ISOBUTYLBENZENE-1-SULFONAMIDE Ethanol

Preparation Products

Darunavir ethanolate Suppliers

Global( 226)Suppliers
Supplier Tel Email Country ProdList Advantage
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497 sales01@cooperate-pharm.com CHINA 1811 55
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21695 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32480 60
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
TianYuan Pharmaceutical CO.,LTD 		+86-755-23284190 13684996853 sales@tianpharm.com CHINA 304 58
Biochempartner 		0086-13720134139 candy@biochempartner.com CHINA 967 58
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28180 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
Chongqing Chemdad Co., Ltd 		+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
Neostar United (Changzhou) Industrial Co., Ltd. 		+86-519-519-85557386 marketing1@neostarunited.com China 8349 58
Supplier Advantage
Beijing Cooperate Pharmaceutical Co.,Ltd 		55
Henan Tianfu Chemical Co.,Ltd. 		55
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
TianYuan Pharmaceutical CO.,LTD 		58
Biochempartner 		58
Hubei Jusheng Technology Co.,Ltd. 		58
BOC Sciences 		58
Chongqing Chemdad Co., Ltd 		58
Neostar United (Changzhou) Industrial Co., Ltd. 		58

Related articles

View Lastest Price from Darunavir ethanolate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Darunavir ethanolate pictures 2024-04-10 Darunavir ethanolate
635728-49-3
 US $0.00 / Kg/Bag 2Kg/Bag 0.0099 20 tons Sinoway Industrial co., ltd.
Unii-33o78xf0bw pictures 2023-06-15 Unii-33o78xf0bw
635728-49-3
 US $63.00 / g 1g 98% 100kg Baoji Guokang Bio-Technology Co., Ltd.
Unii-33o78xf0bw pictures 2021-07-13 Unii-33o78xf0bw
635728-49-3
 US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
  • Unii-33o78xf0bw pictures
  • Unii-33o78xf0bw
    635728-49-3
  • US $63.00 / g
  • 98%
  • Baoji Guokang Bio-Technology Co., Ltd.
  • Unii-33o78xf0bw pictures
  • Unii-33o78xf0bw
    635728-49-3
  • US $15.00-10.00 / KG
  • 99%+ HPLC
  • Zhuozhou Wenxi import and Export Co., Ltd

Darunavir ethanolate Spectrum

Unii-33o78xf0bw(635728-49-3)1HNMR

635728-49-3(Darunavir ethanolate)Related Search:

1-epi-Darunavir (3aS,4R,6aR)-Tetrahydro-4-Methoxyfuro[3,4-b]furan-2(3H)-one BIS THF Nitro Derivative 2 Darunavir O-β-D-Glucuronide BIS THF HNS Derivative 3
Repaglinide Pazopanib Hydrochloride 4-Hydroxy Darunavir [(3R,3aS,6aR)-Hydroxyhexahydrofuro[2,3-β]furanyl Succinimidyl Carbonate tert-Butyl [(1S,2R)-1-benzyl-2-hydroxy-3-[isobutyl[(4-nitrophenyl)sulfonyl]amino]propyl]carbamate
Darunavir (3R,3αS,6αR)-Hexahydrofuro[2,3-β]furan-3-yl-4-nitrophenyl carbonate 4-AMINO-N-[(2R,3S)-3-AMINO-2-HYDROXY-4-PHENYLBUTYL]-N-ISOBUTYLBENZENE-1-SULFONAMIDE 4-[[4-[[4-[(E)-2-cyanoethenyl]-2,6-dimethyl-phenyl]amino]pyrimidin-2-yl]amino]benzonitrile GSK1349572
Raltegravir Etravirine Atazanavir sulfate

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Unii-33o78xf0bw N-[(1S,2R)-3-[[(4-Aminophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl ester compd. with ethanol Darunavir Ethanolate(Prezista) Darunavir(TMC-114,UIC 94017) Ethanolate N-[(1S,2R)-3-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]-, (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl carbamic acid ester, compd. with ethanol (1:1) (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl ((2S,3R)-4-(4-amino-N-isobutylphenylsulfonamido)-3-hydroxy-1-phenylbutan-2-yl)carbamate compound with ethanol (1:1) [14C]-Darunavir ethanolate DARUNAVIR ETHANOLATE (TMC114 ETHANOLATE) Darunavir Ethanolate (DRV, Prezista) Darunavir EthanolateQ: What is Darunavir Ethanolate Q: What is the CAS Number of Darunavir Ethanolate Q: What is the storage condition of Darunavir Ethanolate Q: What are the applications of Darunavir Ethanolate To the drug Carbamic acid, ((1S,2R)-3-(((4-aminophenyl)sulfonyl)(2-methylpropyl)amino)-2-hydroxy-1-(phenylmethyl)propyl)-, (3R,3as,6ar)-hexahydrofuro(2,3-B)furan-3-yl ester, compd. with ethanol (1:1) Darunavir ethanolate (3R,3AS,6aR)-Hexahydrofuro[2,3-b]furan-3-yl ((2S,3R)-4-(4-amino-N-isobutylphenylsulfonamido)-3-hydroxy-1-phenylbutan-2-yl)carbamate Ethanolate Darunavir hemiethanolate salt Darunavir Ethanolate (100 mg) 635728-49-3 C27H37N3O7SC2H6O C27H37N3O7SC2H5OH C29H43N3O8S Inhibitor Prezista, TMC114 Other APIs Inhibitors API