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ChemicalBook >> CAS DataBase List >>7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one

7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one

7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one Structure
7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one structure
CAS No.
137982-91-3
Chemical Name:
7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one
Synonyms
1H-benzo[b]azepine;Tovaptan impurity 32;Tovaptan impurity 12;Tolvaptan Impurity 12;Tolvaptan InterMediates;7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1...;7-chloro-1-(2-methyl-4-nitrobenzoyl)-3,4-dihydro-2H-1-benzazepin-5-one;7-chloro-1-(2-Methyl-4-nitrobenzoyl)-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one;7-Chloro-5-oxo-1-(2-methyl-4-nitrobenzoyl)-2,3,4,5-tetrahydro-1H-benzazepine;7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one
CBNumber:
CB32500622
Molecular Formula:
C18H15ClN2O4
Molecular Weight:
358.78
MDL Number:
MFCD19440800
MOL File:
137982-91-3.mol
Last updated:2024-01-02 18:26:26
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7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one Properties

Melting point 152 - 155°C
Boiling point 573.3±50.0 °C(Predicted)
Density 1.387
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka -2.58±0.20(Predicted)
color White to Off-White
InChI InChI=1S/C18H15ClN2O4/c1-11-9-13(21(24)25)5-6-14(11)18(23)20-8-2-3-17(22)15-10-12(19)4-7-16(15)20/h4-7,9-10H,2-3,8H2,1H3
InChIKey NNCRQBJNAGEBDM-UHFFFAOYSA-N
SMILES N1(C(=O)C2=CC=C([N+]([O-])=O)C=C2C)C2=CC=C(Cl)C=C2C(=O)CCC1
FDA UNII EWB5QJ6P82

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC C366123 7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one 137982-91-3 50mg $460 2021-12-16 Buy
TRC C366123 7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one 137982-91-3 250mg $1965 2021-12-16 Buy
Biosynth Carbosynth FC151725 7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one 137982-91-3 50mg $704 2021-12-16 Buy
AK Scientific Z3612 7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5h-1-benzazepin-5-one 137982-91-3 50mg $1000 2021-12-16 Buy
American Custom Chemicals Corporation HCH0368292 7-CHLORO-1-(2-METHYL-4-NITROBENZOYL)-3,4-DIHYDRO-1H-BENZO[B]AZEPIN-5(2H)-ONE 95.00% 137982-91-3 5MG $499.6 2021-12-16 Buy
Product number Packaging Price Buy
C366123 50mg $460 Buy
C366123 250mg $1965 Buy
FC151725 50mg $704 Buy
Z3612 50mg $1000 Buy
HCH0368292 5MG $499.6 Buy

7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one Chemical Properties,Uses,Production

Uses

7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one is an intermediate in synthesizing Tolvaptan-d7 (T536652), a labelled Tolvaptan (T536650). It is a selective, competitive arginine vasopressin V2 receptor antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH).

7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one Preparation Products And Raw materials

Raw materials

Preparation Products

7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one Suppliers

Global( 120)Suppliers
Supplier Tel Email Country ProdList Advantage
Enki Biopharmaceuticals (Shanghai) Limited
+86-0086-2157680326 +8613916707528 yusu@enkibiopharma.com China 47 58
Capot Chemical Co.,Ltd. 		571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21691 55
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Cangzhou Wanyou New Material Technology Co.,Ltd 		18631714998 sales@czwytech.com CHINA 906 58
Shandong chuangyingchemical Co., Ltd. 		18853181302 sale@chuangyingchem.com CHINA 5909 58
Standardpharm Co. Ltd. 		86-714-3992388 overseasales1@yongstandards.com United States 14336 58
Chongqing Chemdad Co., Ltd 		+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
Shanghai Jinghao Pharmaceutical Co.,Ltd 		+86-21-68900963 sales@jinghaopharma.com CHINA 153 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 47465 58
Supplier Advantage
Enki Biopharmaceuticals (Shanghai) Limited
58
Capot Chemical Co.,Ltd. 		60
Henan Tianfu Chemical Co.,Ltd. 		55
career henan chemical co 		58
Cangzhou Wanyou New Material Technology Co.,Ltd 		58
Shandong chuangyingchemical Co., Ltd. 		58
Standardpharm Co. Ltd. 		58
Chongqing Chemdad Co., Ltd 		58
Shanghai Jinghao Pharmaceutical Co.,Ltd 		58
CONIER CHEM AND PHARMA LIMITED 		58

View Lastest Price from 7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5h-1-benzazepin-5-one pictures 2024-04-25 7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5h-1-benzazepin-5-one
137982-91-3
 US $0.00-0.00 / kg 1kg 99.0% 20000 Enki Biopharmaceuticals (Shanghai) Limited
Tolvaptan Intermediates pictures 2019-08-05 Tolvaptan Intermediates
137982-91-3
 US $1.00 / g 1g 99% 20000kg Cangzhou Wanyou New Material Technology Co.,Ltd
7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one pictures 2019-07-06 7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one
137982-91-3
 US $2.00 / kg 1kg 99% Ask Career Henan Chemical Co

137982-91-3(7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one)Related Search:

Ethyl 7-Chloro-5-oxo-1-toxyl-2,3,4,5,-tetrahydro-1H-benzo[b]azepine-4-carboxylate Tolvaptan Impurity 18 Tolvaptan Impurity 13 5-Chloro-2-[(4-ethoxy-4-oxobutyl)[(4-methylphenyl)sulfonyl]amino]benzoic acid methyl ester Tolvaptan Impurity 21
Tolvaptan Impurity 3 (DM-4104) Tolvaptan Impurity 30 7-Chloro-1,2,3,4-tetrahydro-1-[(4-methylphenyl)sulfonyl]-5H-1-benzazepin-5-one Tolvaptan Impurity 17 Tolvaptan impurity 2
Tolvaptan Impurity 20 Tolvaptan Impurity 15 Tolvaptan Impurity 11 Tolvaptan Impurity 26 Tolvaptan
7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one 5-Dehydro Tolvaptan 1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one

1of4

7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one Tolvaptan InterMediates 7-chloro-1-(2-Methyl-4-nitrobenzoyl)-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one 7-Chloro-1,2,3,4-Tetrahydro-1-(2-Methyl-4-Nitrobenzoyl)-5H-1-Benzazepine-5-One 7-chloro-1-(2-methyl-4-nitrobenzoyl)-3,4-dihydro-2H-1-benzazepin-5-one 7-chloro-1-(2-methyl-4-nitrobenzoyl)-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one Tolvaptan Impurity 12 5H-1-Benzazepin-5-one, 7-chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)- 7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one CAS 7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1... 1H-benzo[b]azepine 7- chloro -1,2,3,4- tetrahydro -1-(2- methyl -4- nitrobenzoyl) -5H-1- benzoazepine -5- one * Tovaptan impurity 32 Tovaptan impurity 12 7-chloro-1-(2-methyl-4-(2-methylbenzamido)benzoyl)-2,3-dihydro-1H-benzo[b]azepin-5-yl 2-methylbenzoate 7-Chloro-5-oxo-1-(2-methyl-4-nitrobenzoyl)-2,3,4,5-tetrahydro-1H-benzazepine 137982-91-3 Pharmaceutical Intermediates