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Y-39983 hydrochloride

Y-39983 hydrochloride Structure
Y-39983 hydrochloride structure
CAS No.
471843-75-1
Chemical Name:
Y-39983 hydrochloride
Synonyms
Y 39983;Y-39983 HCI;Y 39983, (HCl);(594859-54-8) y 39983;Y-33075 (hydrochloride);4-[(1R)-1-Aminoethyl]-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide hydrochloride;(R)-4-(1-Aminoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzamide hydrochloride;4-[(1R)-1-Aminoethyl]-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide hydrochloride ISO 9001：2015 REACH
CBNumber:
CB32509933
Molecular Formula:
C16H16N4O.HCl
Molecular Weight:
316.78538
MDL Number:
MOL File:
471843-75-1.mol
MSDS File:
SDS
Last updated:2023-07-02 16:12:59
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Y-39983 hydrochloride Properties

storage temp. -20°C
solubility DMSO: soluble
form A solid
FDA UNII 3304VH0J6B

Y-39983 hydrochloride price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
American Custom Chemicals Corporation API0014196 Y-39983 95.00% 471843-75-1 5MG $502.87 2021-12-16 Buy
Biorbyt Ltd orb611891 Y-39983 >98% 471843-75-1 50mg $765 2021-12-16 Buy
Product number Packaging Price Buy
API0014196 5MG $502.87 Buy
orb611891 50mg $765 Buy

Y-39983 hydrochloride Chemical Properties,Uses,Production

Description

Y-39983 hydrochloride, also known as Y-33075, is a selective Rho-associated coiled coil-forming protein kinase (ROCK) inhibitor derived from Y-27632, and is more potent than Y-27632, with an IC50 of 3.6 nM.

in vitro

In rabbits, topical administration of Y-39983 significantly increased conventional outflow by 65.5%, followed by significant, dose-dependent reduction in IOP. Maximum IOP reduction was 13.2 ± 0.6 mm Hg (mean ± SE) at 0.1% Y-39983 in rabbits. In monkeys, at 3 hours after topical administration of 0.05% Y-39983, maximum reduction of IOP was 2.5 ± 0.8 mm Hg. No serious side effects were observed in ocular tissues except sporadic punctate subconjunctival hemorrhage during long-term topical administration of Y-39983 four times a day (at 2-hour intervals) in rabbits or monkeys. However, punctate subconjunctival hemorrhage was not observed with administration twice daily (at a 6-hour interval) or three times a day (at 5-hour intervals).

References

[1]. Hideki Tokushige, et al. Effects of Topical Administration of Y-39983, a Selective Rho-Associated Protein Kinase Inhibitor, on Ocular Tissues in Rabbits and Monkeys Invest. Ophthalmol. Vis. Sci. July 2007 vol. 48no. 7 3216-3222 DOI:10.1167/IOVS.05-1617
[2]. Tokushige H, et al. Effects of Y-39983, a selective Rho-associated protein kinase inhibitor, on blood flow in optic nerve head in rabbits and axonal regeneration of retinal ganglion cells in rats. Curr Eye Res. 2011 Oct;36(10):964-70. DOI:10.3109/02713683.2011.599106
[3]. Watabe H, et al. Effects of Rho-associated protein kinase inhibitors Y-27632 and Y-39983 on isolated rabbit ciliary arteries.Jpn J Ophthalmol. 2011 Jul;55(4):411-7. Epub 2011 Jun 11. DOI:10.1007/s10384-011-0048-9

Y-39983 hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Y-39983 hydrochloride Suppliers

Global( 18)Suppliers
Supplier Tel Email Country ProdList Advantage
Hubei xin bonus chemical co. LTD 		86-13657291602 linda@hubeijusheng.com CHINA 22968 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 47465 58
Shaanxi Dideu Medichem Co. Ltd 		+86-029-89586680 +86-18192503167 1026@dideu.com China 9409 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 29322 58
Nantong HI-FUTURE Biology Co., Ltd. 		+undefined18051384581 sales@chemhifuture.com China 3136 58
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 sales-cpd@caerulumpharma.com China 3419 58
Shanghai Han-Xiang Chemical Co., Ltd. 15971444841 amber@biochempartner.com China 3063 58
DC Chemicals 021-58447131 13564518121 sales@dcchemicals.com China 9414 58
Beijing xinyanhui pharmaceutical research and development co., LTD 13969155946 1461866103@qq.com China 16111 58
Taizhou Nanfeng Pharmaceutical Research Institute 12345678910 nanfengdrug@163.com China 15323 58
Supplier Advantage
Hubei xin bonus chemical co. LTD 		58
CONIER CHEM AND PHARMA LIMITED 		58
Shaanxi Dideu Medichem Co. Ltd 		58
Dideu Industries Group Limited 		58
Nantong HI-FUTURE Biology Co., Ltd. 		58
ShangHai Caerulum Pharma Discovery Co., Ltd. 58
Shanghai Han-Xiang Chemical Co., Ltd. 58
DC Chemicals 58
Beijing xinyanhui pharmaceutical research and development co., LTD 58
Taizhou Nanfeng Pharmaceutical Research Institute 58

View Lastest Price from Y-39983 hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-[(1R)-1-Aminoethyl]-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide hydrochloride pictures 2024-04-17 4-[(1R)-1-Aminoethyl]-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide hydrochloride
471843-75-1
 US $1.10 / g 1g 99.0% min 100 tons min Shaanxi Dideu Medichem Co. Ltd
4-[(1R)-1-Aminoethyl]-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide hydrochloride pictures 2021-10-15 4-[(1R)-1-Aminoethyl]-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide hydrochloride
471843-75-1
 US $1.10 / g 1g 99.00% 100 Tons Min Dideu Industries Group Limited
Y 39983 4-[(1R)-1-Aminoethyl]-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide hydrochloride Y 39983, (HCl) (594859-54-8) y 39983 4-[(1R)-1-Aminoethyl]-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide hydrochloride ISO 9001：2015 REACH Y-39983 HCI (R)-4-(1-Aminoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzamide hydrochloride Y-33075 (hydrochloride) 471843-75-1 C16H16N4OHCl C16H16N4OClH