Tolbutamide-d9
- CAS No.
- 1219794-57-6
- Chemical Name:
- Tolbutamide-d9
- Synonyms
- Mobenol-d9;Artozin-d9;Artosin-d9;[2H9]-Tolbutamide;Tolylsulfonylbutylurea-d9;Tolbutamide-d9 Solution, 100ppm;3-(p-Tolyl-4-sulfonyl)-1-butylurea-d9;1-(Butyl-3-(p-tolyl- sulfonyl)urea-d9;N-Butyl-N'-(4-Methylphenylsulfonyl)urea-d9;N-[(ButylaMino-d9)carbonyl]-4-MethylbenzenesulfonaMide
- CBNumber:
- CB32512331
- Molecular Formula:
- C12H18N2O3S
- Molecular Weight:
- 270.35
- MDL Number:
- MOL File:
- 1219794-57-6.mol
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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Signal word | Warning | |||||||||
NFPA 704 |
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Tolbutamide-d9 price More Price(9)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 30738 | Tolbutamide-d9 | 1219794-57-6 | 1mg | $73 | 2024-03-01 | Buy |
Cayman Chemical | 30738 | Tolbutamide-d9 | 1219794-57-6 | 10mg | $575 | 2024-03-01 | Buy |
Cayman Chemical | 30738 | Tolbutamide-d9 | 1219794-57-6 | 5mg | $324 | 2024-03-01 | Buy |
TRC | T535152 | Tolbutamide-d9 | 1219794-57-6 | 25mg | $1355 | 2021-12-16 | Buy |
Medical Isotopes, Inc. | D2584 | Tolbutamide-d9(butyl-d9) | 1219794-57-6 | 0.05g | $1700 | 2021-12-16 | Buy |
Tolbutamide-d9 Chemical Properties,Uses,Production
Description
Tolbutamide-d9 is intended for use as an internal standard for the quantification of tolbutamide by GC- or LC-MS. Tolbutamide is an inhibitor of sulfonylurea receptor 1 (SUR1) linked to ATP-sensitive potassium channel Kir6.2 (IC50 = 4.9 μM). It is selective for SUR1/Kir6.2 over SUR2A/Kir6.2 and SUR2B/Kir6.2 channels (IC50s = 85 and 88 μM, respectively). Tolbutamide increases glucose-induced insulin secretion and calcium influx in isolated mouse pancreatic islets. In vivo, tolbutamide (80 mg/kg) reduces blood glucose levels in a mouse model of diabetes induced by streptozotocin (STZ; ). Formulations containing tolbutamide have been used in the treatment of type 2 diabetes.
Chemical Properties
White Solid
Uses
Labelled Tolbutamide (T535150). An antidiabetic, used as a hypoglycemic agent in veterinary medicine.
Tolbutamide-d9 Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
Chemsky(shanghai)International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32344 | 50 |
Alta Scientific Co., Ltd. | 022-6537-8550 15522853686 | sales@altasci.com.cn | China | 4515 | 55 |
Nanjing Haolv Biotechnology Co.,Ltd | 025-84622273 02584622273; | kexin.zhou@haolvbiotech.com | China | 3021 | 58 |
Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 | sales@rrkchem.com | China | 55717 | 58 |
Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44894 | 58 |
ChengDu SinoStandards Bio-Tech Co.,Ltd. , | 028-83243028 19136088901 | sinostandards@163.com | China | 5044 | 58 |
Yancheng Tongming Biotechnology Co., Ltd. | 15195160625 | 2863565288@qq.com | China | 5194 | 58 |
ChemeGen 中国 | 18818260767 | sales@chemegen.com | China | 6975 | 58 |