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Daclatasvir Dihydrochloride

Daclatasvir Dihydrochloride structure

CAS No.: 1009119-65-6

Chemical Name:: Daclatasvir Dihydrochloride

Synonyms: BMS 790052;Declatasvir;BMS790052 HCl;Daclatasvir API;BMS-790052 2HCl;Daclatasvir HCL;DACLATASVIR(2HCl);Daclatasvir DiHCl;Daclatasvir/Daklinza;BMS 790052 (di HClsalt)

CBNumber:: CB32514542

Molecular Formula:: C40H51ClN8O6

Molecular Weight:: 775.35

MDL Number:: MFCD25541736

MOL File:: 1009119-65-6.mol

Last updated:2023-05-18 11:31:01

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Daclatasvir Dihydrochloride Properties

Melting point	>207°C (dec.)
storage temp.	-20°C Freezer
solubility	DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form	Solid
color	Off-White to Yellow
FDA UNII	50ZO25C11D

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07,GHS08
Signal word	Warning
Hazard statements	H317-H373-H335-H319
Precautionary statements	P261-P272-P280-P302+P352-P333+P313-P321-P363-P501-P260-P314-P501-P264-P280-P305+P351+P338-P337+P313P

Daclatasvir Dihydrochloride price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	D101505	DaclatasvirDihydrochloride	1009119-65-6	100mg	$1320	2021-12-16	Buy
Biorbyt Ltd	orb181228	Daclatasvir dihydrochloride (BMS-790052) >99%	1009119-65-6	1g	$1208.7	2021-12-16	Buy
Biorbyt Ltd	orb181228	Daclatasvir dihydrochloride (BMS-790052) >99%	1009119-65-6	100mg	$414.8	2021-12-16	Buy
Biorbyt Ltd	orb181228	Daclatasvir dihydrochloride (BMS-790052) >99%	1009119-65-6	250mg	$615.4	2021-12-16	Buy
ChemScene	CS-0270	Daclatasvir(dihydrochloride) 99.62%	1009119-65-6	5mg	$50	2021-12-16	Buy

Product number	Packaging	Price	Buy
D101505	100mg	$1320	Buy
orb181228	1g	$1208.7	Buy
orb181228	100mg	$414.8	Buy
orb181228	250mg	$615.4	Buy
CS-0270	5mg	$50	Buy

Daclatasvir Dihydrochloride Chemical Properties,Uses,Production

Description

Daclatasvir dihydrochloride is a hepatitis C virus nonstructural 5A (NS5A) replication complex inhibitor which was first approved in Japan for the treatment of genotype 1 HCV patients who fail to respond to interferon plus ribavirin. The drug has also been approved for patients with untreated, chronic HCV who are eligible for interferon. Additionally, in Europe, daclatasvir was approved for use in combination with other products across genotype 1–4 HCV. Daclatasvir was discovered and developed by Bristol–Myers Squibb and a fascinating account describing the initiation of the program from a phenotypic screen and the medicinal chemistry strategy leading to the discovery of the compound has been recently reported.

Chemical Properties

Daclatasvir dihydrochloride is white to yellow powder. It is freely soluble in water (>700 mg/mL). The solubility is strongly pH-dependent and the solubility is high at low pH values.

Uses

Daclatasvir Dihydrochloride is the dihydrochloride salt form of daclatasvir, an orally available inhibitor of the hepatitis C virus (HCV) non-structural protein 5A (NS5A) replication complex, with potential activity against HCV. Daclatasvir is used with another antiviral medication (sofosbuvir) to treat chronic (long-lasting) hepatitis C, a viral infection of the liver. Daclatasvir should never be used without sofosbuvir. Daclatasvir and sofosbuvir may also be used with another antiviral medication (ribavirin).

Definition

ChEBI: Daclatasvir hydrochloride is a hydrochloride obtained by combining daclatasvir with two molar equivalents of hydrochloric acid. It is a potent inhibitor of nonstructural protein 5A and is used for treatment of hepatitis C. It has a role as an antiviral drug and a nonstructural protein 5A inhibitor. It contains a daclatasvir(2+).

Synthesis

Bromination of commercial 4,40-diacetylbiphenyl (58) gave 4,40-bis(bromoacetyl)biphenyl 59 in 82% yield. Alkylation of NBoc- L-proline (60) with 59 gave diester 61 which was treated with ammonium acetate to effect cyclization of the bis-ketoester to provide bis-imidazole 62 in 63% yield for the two steps. Acidic removal of the Boc protecting groups followed by recrystallization provided bis-pyrrolidine 63 in high yield. Acylation of 63 with N-(methoxycarbonyl)- L-valine (64) using N-(3-dimethylaminopropyl)-N0-ethylcarbodiimide (EDC) and 1-hydroxybenxotriazole hydrate (HOBT) provided declatasvir. The dihydrochloride salt was prepared and treated with Cuno Zet Carbon ® followed by crystallization from acetone to give daclatasvir dihydrochloride (IX) in 74% yield. Synthesis_1009119-65-6

Mode of action

Daclatasvir is an inhibitor of nonstructural protein 5A (NS5A), a multifunctional protein that is an essential component of the HCV replication complex. Daclatasvir binds to the N-terminus of NS5A and inhibits both viral RNA replication and virion assembly.

Daclatasvir Dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Daclatasvir Dihydrochloride Suppliers

Global( 278)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1811	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3012	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Nanjing Dolon Biotechnology Co.,Ltd.	18905173768	sales@dolonchem.com	CHINA	2972	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14336	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55
Nanjing ChemLin Chemical Industry Co., Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Nanjing Dolon Biotechnology Co.,Ltd.	58
Hubei Jusheng Technology Co.,Ltd.	58
Standardpharm Co. Ltd.	58
BOC Sciences	58

View Lastest Price from Daclatasvir Dihydrochloride manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-22	Daclatasvir 1009119-65-6	US $0.00 / Kg/Bag	2Kg/Bag	99% up, High Density	20 tons	Sinoway Industrial co., ltd.
2022-09-08	Daclatasvir Dihydrochloride 1009119-65-6	US $0.00-0.00 / kg	1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.
2021-09-16	Daclatasvir Dihydrochloride 1009119-65-6	US $0.00 / KG	1KG	99%	1000KG	Hangzhou Huarong Pharm Co., Ltd.

Daclatasvir
1009119-65-6
US $0.00 / Kg/Bag
99% up, High Density
Sinoway Industrial co., ltd.

Daclatasvir Dihydrochloride
1009119-65-6
US $0.00-0.00 / kg
98%
Henan Aochuang Chemical Co.,Ltd.

Daclatasvir Dihydrochloride
1009119-65-6
US $0.00 / KG
99%
Hangzhou Huarong Pharm Co., Ltd.

Daclatasvir Dihydrochloride Spectrum

Daclatasvir Dihydrochloride(1009119-65-6)¹HNMR

1009119-65-6(Daclatasvir Dihydrochloride)Related Search:

Daclatasvir tadalafi methyl ((S)-1-((S)-2-(5-(4'-(2-((S)-1-((S)-2-amino-3-methylbutanoyl)pyrrolidin-2-yl)-1H-imidazol-4-yl)-[1,1'-biphenyl]-4-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate Daclatasvir Impurity 5 (SRSS-Isomer) Daclatasvir Impurity F

Daclatasvir Impurity 1-{4'-acetyl-[1,1'-biphenyl]-4-yl}-2-bromoethan-1-one Daclatasvir Impurity 7 1,1'-[1,1'-biphenyl]-4,4'-diylbis[2,2-dibromo]-ethanone

1of2

BMS 790052 N,N'-[[1,1'-Biphenyl]-4,4'-diylbis[1H-imidazole-5,2-diyl-(2S)-2,1-pyrrolidinediyl[(1S)-1-(1-methylethyl)-2-oxo-2,1-ethanediyl]]]biscarbamic acid dimethyl ester hydrochloride Daclatasvir`Daclatasvir dihydrochloride Dclatasvir dihydrochloride Daclatasvir Digydrochloride Carbamic acid, N,N'-[[1,1'-biphenyl]-4,4'-diylbis[1H-imidazole-5,2-diyl-(2S)-2,1-pyrrolidinediyl[(1S)-1-(1-methylethyl)-2-oxo-2,1-ethanediyl]]]bis-, C,C'-dimethyl ester, hydrochloride (1:2) Daclatasvir API Dackatasvir dihydrochloride daclatasvir hydrochloride BMS-790052 (dihydrochloride) BMS790052 HCl Daclatasvir dihydrochloride BMS-790052 2HCl DACLATASVIR(2HCl) Daclatasvir HCL Methyl (1-((2S)-2-(5-(4'-(2-(1-((methoxycarbonyl)valyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)-[1,1'-biphenyl]-4-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate hydrochloride Daclatasivir Dihydrochloride Daclatasvir/Daklinza dimethyl ((2S,2'S)-((2S,2'S)-2,2'-(5,5'-([1,1'-biphenyl]-4,4'-diyl)bis(1H-imidazole-5,2-diyl))bis(pyrrolidine-2,1-diyl))bis(3-methyl-1-oxobutane-2,1-diyl))dicarbamate Daclatasvir dihydrochloride, >=98% BMS-790052;BMS790052 ;BMS 790052;DACLATASVIR;BMS-790052 DIHYDROCHLORIDE;BMS790052 DIHYDROCHLORIDE;BMS 790052 DIHYDROCHLORIDE BMS-790052; BMS790052 ; BMS 790052;DACLATASVIR Daclatasvir dihydrochloride (BMS-790052) BMS 790052 (di HClsalt) N,N'-[[1,1'-Biphenyl]-4,4'-diylbis[1H-imidazole-5,2-diyl-(2S)-2,1-pyrrolidinediyl[(1S)-1-(1-methylethyl)- Daclatasvir dihydrochloride (BMS-790052 dihydrochloride) Dacatavir dihydrochloride Daclatavir Dihydrochloride Daclatasvir DiHCl N,N'-[[1,1'-Biphenyl]-4,4'-diylbis[1H-imidazole-5,2-diyl-(2S)-2,1-pyrrolidinediyl[(1S)-1-(1-methylethyl)-2-oxo-2,1-ethanediyl]]]biscarbamic acid dimethyl ester hydrochloride USP/EP/BP Daclatasvir dihydrochlorid methyl N-[(2S)-1-[(2S)-2-[5-(4'-{2-[(2S)-1-[(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl]pyrrolidin-2-yl]-1H-imidazol-5-yl}-[1,1'-biphenyl]-4-yl)-1H-imidazol-2-yl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate dihydrochloride TIANFU CHEM---N,N'-[[1,1'-Biphenyl]-4,4'-diylbis[1H-imidazole-5,2-diyl-(2S)-2,1-pyrrolidinediyl[(1S)-1-(1-methylethyl)-2-oxo-2,1-ethanediyl]]]biscarbamic acid dimethyl ester hydrochloride Daclatasvir dihydrochloride(BMS-790052) Competitive price/Top quality Methyl ((S)-1-((S)-2-(5-(4'-(2-((S)-1-((methoxycarbonyl)-L-valyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)-[1,1'-biphenyl]-4-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate dihydrochloride Declatasvir Daclatasvir Hcl In-House methyl N-[(2S)-1-[(2S)-2-{4-[4-(4-{2-[(2S)-1-[(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl]pyrrolidin-2-yl]-1H-imidazol-4-yl}phenyl)phenyl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate.dihydrochloride Methyl ((S)-1-((S)-2-(5-(4'-(2-((S)-1-((methoxycarbonyl)-L-valyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)-[1,1'-biphenyl]-4-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate dihydrochloride 1009119-65-6 C40H52Cl2N8O6 C40H50N8O62HCl C40H50N8O62ClH Inhibitors