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1,1,1,3,3,3-Hexafluoro-2-propanol

Description Clinical application Hazards Preparation
1,1,1,3,3,3-Hexafluoro-2-propanol
1,1,1,3,3,3-Hexafluoro-2-propanol structure
CAS No.
920-66-1
Chemical Name:
1,1,1,3,3,3-Hexafluoro-2-propanol
Synonyms
HFP;HFIP;HFIPA;F6IPROH;CF3CH(OH)CF3;1,1,1,3,3,3-;JACS-920-66-1;COAGULASETEST;uoro-2-propanoL;1,1,1,3,3,3-HexafL
CBNumber:
CB3251829
Molecular Formula:
C3H2F6O
Formula Weight:
168.04
MOL File:
920-66-1.mol

1,1,1,3,3,3-Hexafluoro-2-propanol Properties

Melting point:
−4 °C(lit.)
Boiling point:
59 °C(lit.)
Density 
1.596 g/mL at 25 °C(lit.)
vapor pressure 
269 hPa (30 °C)
refractive index 
n20/D 1.275(lit.)
Flash point:
4,4°C
storage temp. 
Store at RT.
pka
pK1:9.42 (25°C)
form 
Solid
color 
White to yellow
Specific Gravity
1.596
PH
3-4 (H2O)Aqueous solution
Water Solubility 
1000 g/L (25 ºC)
λmax
229nm(lit.)
BRN 
1841007
Stability:
Stable. Incompatible with strong acids, strong bases, alkali metals.
InChIKey
BYEAHWXPCBROCE-UHFFFAOYSA-N
CAS DataBase Reference
920-66-1(CAS DataBase Reference)
EWG's Food Scores
1
FDA UNII
3D632GYQ50
NIST Chemistry Reference
2-Propanol, 1,1,1,3,3,3-hexafluoro-(920-66-1)
EPA Substance Registry System
1,1,1,3,3,3-Hexafluoro-2-propanol (920-66-1)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS05,GHS07,GHS08
Signal word  Danger
Hazard statements  H318-H332-H302-H314-H361
Precautionary statements  P260h-P301+P330+P331-P405-P501a-P260-P280-P301+P312+P330-P303+P361+P353-P304+P340+P310-P305+P351+P338
Hazard Codes  C,Xi
Risk Statements  20/22-34
Safety Statements  26-36/37/39-45-27
RIDADR  UN 2922 8/PG 2
WGK Germany  2
RTECS  UB6450000
27
Hazard Note  Corrosive
TSCA  T
HazardClass  8
PackingGroup  II
HS Code  29055910
Toxicity LD50 orally in Rabbit: 1500 mg/kg

1,1,1,3,3,3-Hexafluoro-2-propanol price More Price(20)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 105228 1,1,1,3,3,3-Hexafluoro-2-propanol ≥99% 920-66-1 5g $38.9 2019-12-02 Buy
Sigma-Aldrich 105228 1,1,1,3,3,3-Hexafluoro-2-propanol ≥99% 920-66-1 2kg $1960 2019-12-02 Buy
TCI Chemical H0424 1,1,1,3,3,3-Hexafluoro-2-propanol >99.0%(GC) 920-66-1 25g $77 2020-06-24 Buy
TCI Chemical H0424 1,1,1,3,3,3-Hexafluoro-2-propanol >99.0%(GC) 920-66-1 100g $257 2020-06-24 Buy
Alfa Aesar A12747 1,1,1,3,3,3-Hexafluoro-2-propanol, 99+% 920-66-1 5g $38.7 2020-06-24 Buy

1,1,1,3,3,3-Hexafluoro-2-propanol Chemical Properties,Uses,Production

Description

Hexafluoroisopropanol (HFIP) is a viscous and colorless liquid with scary odorless. It is an ideal solvent for dissolving polyamides and esters, and it can be used to analyze nylon. Typically, a small amount of sodium trifluoroacetate can be added to the eluent to reduce the aggregation of the sample. HFIP has a certain viscosity, but its boiling point is very low, so we need to analyst under the conditions of 40 ° C to reduce the back pressure of the column. Hexafluoroisopropanol is also a highly polar solvent that results in a non-linearity of the calibration curve obtained from the mixed column bed column. Therefore, Agilent has developed a special column-PL HFIPgel column for this solvent, which has a porous structure that is not affected by solvents.

Clinical application

Hexafluoroisopropanol(1,1,1,3,3,3-Hexafluoro-2-propanol) can be used to prepare a variety of high-end chemicals such as fluorosurfactants, fluorine-containing emulsifiers, fluorine-containing pharmaceuticals, and used as a solvent or cleaning agent for electronics industry.
The drug can be used as a fluorinated solvent to increase the efficiency of the reaction of rhodium (I)-catalyzed [4 + 2] intramolecular addition reaction of ether bound alkynyl diene and the [5 + 2] cycloaddition of alkynyl vinyl cyclopropane. The drug is a liquid peptide chemical solvent, a highly soluble solvent for peptide and peptide intermediates. The drug can be used for the analysis of multiple polymers.

Hazards

1,1,1,3,3,3-Hexafluoro-2-propanol derives from a propan-2-ol. It is a clear colorless oily liquid with an aromatic odor. (NTP, 1992) Combustible, may cause burns to skin, eyes and mucous membranes.

Preparation

1,1,1,3,3,3-Hexafluoro-2-propanol is prepared from hexafluoropropylene through hexafluoroacetone, which is then hydrogenated.
(CF3)2CO + H2 → (CF3)2CHOH

Chemical Properties

1,1,1,3,3,3-Hexafluoro-2-propanol (HFIP) is a clear, colorless, oily, combustible liquid. Odor is described as aromatic.

Chemical Properties

Colorless liquid

Uses

Hexafluoroisopropanol is used to produce high-end chemicals, such as fluorinated surfactants, fluorinated emulsifier and fluorinated medicine, etc. HFIP is used as a solvent or cleaner in electronic industry.

Uses

1,1,1,3,3,3-Hexafluoro-2-propanol effects the native state of proteins, denaturing them as well as stabilizing the α-helical conformation of unfolded proteins and polypeptides.

Uses

Usually used for preparing hexafluoroalcohol-functionalized methacrylate polymers for lithographic/nanopatterning materials.

Uses

It is used as a polar solvent and exhibits strong hydrogen bonding properties.It dissolves substances that are hydrogen-bond acceptors, such as amides, ethers and a wide range of polymers, including those that are not soluble in the most common organic solvents.

Definition

ChEBI: An organofluorine compound formed by substitution of all the methyl protons in propan-2-ol by fluorine. It is a metabolite of inhalation anesthetic sevoflurane.

Air & Water Reactions

Water soluble.

Reactivity Profile

1,1,1,3,3,3-Hexafluoro-2-propanol is incompatible with acids, acid chlorides and oxidizing agents.

Fire Hazard

1,1,1,3,3,3-Hexafluoro-2-propanol is probably combustible.

Potential Exposure

A specialty solvent for some poly mers; a lavatory reagent.

Shipping

UN1760 Corrosive liquids, n.o.s., Hazard class: 8; Labels: 8-Corrosive material.

Purification Methods

Distil it from 3A molecular sieves, retaining the middle fraction. It has been prepared by reduction of hexafluoroacetone in tetrahydrofuran (THF), In this case hexafluoropropanol forms a stable 1:1 complex which distils at 99-100o/760mm (n 25 1.3283), The complex is decomposed by mixing with 20% oleum and distilling in a vacuum, and the distillate is redistilled to give pure hexafluoropropan-2-ol with b 59o/760mm. The 1H NMR shows a doublet at 4.52ppm (JH,H 2Hz). The benzoyl derivative, [10315-85-2] M 272.1, has m 53.9o after crystalllisation from pentane at -50o, and its IR has at 1760cm-1. [Middleton & Lindsey J Am Chem Soc 86 4948 1964, Urry et al. J Org Chem 32 347 1967.] It has very high peptide solubilising properties, alone or with CH2Cl2 [use as a solvent: Narita et al. Bull Chem Soc Jpn 61 281 1988, Biochemistry 29 2639 1990.] It is CORROSIVE, causes severe eye irritation.

Incompatibilities

HFIP is incompatible with acids, acid chlorides, and oxidizing agents.

Waste Disposal

May be incinerated. In accor dance with 40CFR165, follow recommendations for the disposal of pesticides and pesticide containers. Must be dis posed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste contain ing this contaminant (≥100 kg/mo) must conform to EPA regulations governing storage, transportation, treatment, and waste disposal.

1,1,1,3,3,3-Hexafluoro-2-propanol Preparation Products And Raw materials

Raw materials

Preparation Products


1,1,1,3,3,3-Hexafluoro-2-propanol Suppliers

Global( 374)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Hangzhou FandaChem Co.,Ltd.
0086 158 5814 5714 (Mobile
+86-571-56059825 fandachem@gmail.com CHINA 3252 55
Jinan Finer Chemical Co., Ltd
+86-531-88989536
+86-531-88989539 sales@finerchem.com CHINA 999 58
HENAN BON INDUSTRIAL CO.,LTD
0371-55170695
info@hnbon.com CHINA 20535 58
Haihang Industry Co.,Ltd
86-531-88032799
+86 531 8582 1093 export@haihangchem.com CHINA 10171 58
Capot Chemical Co.,Ltd.
+86-571-85586718
+86-571-85864795 sales@capotchem.com China 19929 60
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21821 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22626 55
Shanghai Time Chemicals CO., Ltd.
+86-021-57951555
+86-021-57951555 jack.li@time-chemicals.com CHINA 1365 55
Fluoropharm Co., Ltd.
+8613336034509
sales@fluoropharm.com CHINA 893 60
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30045 58

Related articles


View Lastest Price from 1,1,1,3,3,3-Hexafluoro-2-propanol manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-03-15 1,1,1,3,3,3-Hexafluoro-2-propanol
920-66-1
US $0.00 / kg 1kg 99.5% 500mt Jinan Finer Chemical Co., Ltd
2020-06-11 1,1,1,3,3,3-Hexafluoro-2-propanol
920-66-1
US $100.00 / Kg/Drum 1000Kg/Drum 99% 20tons Haihang Industry Co.,Ltd
2018-12-16 1,1,1,3,3,3-Hexafluoro-2-propanol
920-66-1
US $8.00 / kg 1kg 98% 10MT career henan chemical co

1,1,1,3,3,3-Hexafluoro-2-propanol Spectrum


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