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Description Clinical application
1,1,1,3,3,3-Hexafluoro-2-propanol structure
Chemical Name:
Molecular Formula:
Formula Weight:
MOL File:

1,1,1,3,3,3-Hexafluoro-2-propanol Properties

Melting point:
−4 °C(lit.)
Boiling point:
59 °C(lit.)
1.596 g/mL at 25 °C(lit.)
vapor pressure 
269 hPa (30 °C)
refractive index 
n20/D 1.275(lit.)
Flash point:
storage temp. 
Store at RT.
pK1:9.42 (25°C)
Specific Gravity
White to yellow
3-4 (H2O)Aqueous solution
Water Solubility 
1000 g/L (25 ºC)
Stable. Incompatible with strong acids, strong bases, alkali metals.
CAS DataBase Reference
920-66-1(CAS DataBase Reference)
NIST Chemistry Reference
2-Propanol, 1,1,1,3,3,3-hexafluoro-(920-66-1)
EPA Substance Registry System
2-Propanol, 1,1,1,3,3,3-hexafluoro-(920-66-1)
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  C,Xi
Risk Statements  20/22-34
Safety Statements  26-36/37/39-45-27
RIDADR  UN 2922 8/PG 2
WGK Germany  2
RTECS  UB6450000
Hazard Note  Corrosive
HazardClass  8
PackingGroup  II
HS Code  29055910
Toxicity LD50 orally in Rabbit: 1500 mg/kg
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H314 Causes severe skin burns and eye damage Skin corrosion/irritation Category 1A, B, C Danger P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
H318 Causes serious eye damage Serious eye damage/eye irritation Category 1 Danger P280, P305+P351+P338, P310
H332 Harmful if inhaled Acute toxicity,inhalation Category 4 Warning P261, P271, P304+P340, P312
H361 Suspected of damaging fertility or the unborn child Reproductive toxicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
Precautionary statements:
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

1,1,1,3,3,3-Hexafluoro-2-propanol price More Price(19)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 105228 1,1,1,3,3,3-Hexafluoro-2-propanol ≥99% 920-66-1 5g $38.4 2018-11-13 Buy
Sigma-Aldrich 105228 1,1,1,3,3,3-Hexafluoro-2-propanol ≥99% 920-66-1 2kg $1910 2018-11-13 Buy
TCI Chemical H0424 1,1,1,3,3,3-Hexafluoro-2-propanol >99.0%(GC) 920-66-1 25g $74 2018-11-22 Buy
TCI Chemical H0424 1,1,1,3,3,3-Hexafluoro-2-propanol >99.0%(GC) 920-66-1 100g $257 2018-11-22 Buy
Alfa Aesar A12747 1,1,1,3,3,3-Hexafluoro-2-propanol, 99+% 920-66-1 5g $36.1 2018-11-13 Buy

1,1,1,3,3,3-Hexafluoro-2-propanol Chemical Properties,Uses,Production


Hexafluoroisopropanol (HFIP) is a viscous and colorless liquid with scary odorless. It is an ideal solvent for dissolving polyamides and esters, and it can be used to analyze nylon. Typically, a small amount of sodium trifluoroacetate can be added to the eluent to reduce the aggregation of the sample. HFIP has a certain viscosity, but its boiling point is very low, so we need to analyst under the conditions of 40 ° C to reduce the back pressure of the column. Hexafluoroisopropanol is also a highly polar solvent that results in a non-linearity of the calibration curve obtained from the mixed column bed column. Therefore, Agilent has developed a special column-PL HFIPgel column for this solvent, which has a porous structure that is not affected by solvents.

Clinical application

Hexafluoroisopropanol(1,1,1,3,3,3-Hexafluoro-2-propanol) can be used to prepare a variety of high-end chemicals such as fluorosurfactants, fluorine-containing emulsifiers, fluorine-containing pharmaceuticals, and used as a solvent or cleaning agent for electronics industry.
The drug can be used as a fluorinated solvent to increase the efficiency of the reaction of rhodium (I)-catalyzed [4 + 2] intramolecular addition reaction of ether bound alkynyl diene and the [5 + 2] cycloaddition of alkynyl vinyl cyclopropane. The drug is a liquid peptide chemical solvent, a highly soluble solvent for peptide and peptide intermediates. The drug can be used for the analysis of multiple polymers.

Chemical Properties

1,1,1,3,3,3-Hexafluoro-2-propanol (HFIP) is a clear, colorless, oily, combustible liquid. Odor is described as aromatic.

Chemical Properties

Colorless liquid


Hexafluoroisopropanol is used to produce high-end chemicals, such as fluorinated surfactants, fluorinated emulsifier and fluorinated medicine, etc. HFIP is used as a solvent or cleaner in electronic industry.


1,1,1,3,3,3-Hexafluoro-2-propanol effects the native state of proteins, denaturing them as well as stabilizing the α-helical conformation of unfolded proteins and polypeptides.


It is used as a polar solvent and exhibits strong hydrogen bonding properties.It dissolves substances that are hydrogen-bond acceptors, such as amides, ethers and a ?wide range of polymers, including those that are not soluble in the most common organic solvents.


Usually used for preparing hexafluoroalcohol-functionalized methacrylate polymers for lithographic/nanopatterning materials.


ChEBI: An organofluorine compound formed by substitution of all the methyl protons in propan-2-ol by fluorine. It is a metabolite of inhalation anesthetic sevoflurane.

Air & Water Reactions

Water soluble.

Reactivity Profile

1,1,1,3,3,3-Hexafluoro-2-propanol is incompatible with acids, acid chlorides and oxidizing agents.

Fire Hazard

1,1,1,3,3,3-Hexafluoro-2-propanol is probably combustible.

Potential Exposure

A specialty solvent for some poly mers; a lavatory reagent.

First aid

Move victim to fresh air. Call 911 or emergency medical service. Give artificial respiration if victim is not breathing. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; give artificial respira tion with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Administer oxygen if breathing is difficult. Remove and isolate contaminated clothing and shoes. In case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes. For minor skin con tact, avoid spreading material on unaffected skin. Keep vic tim warm and quiet. Effects of exposure (inhalation, ingestion or skin contact) to substance may be delayed. Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves. Medical observation is recommended for 24 to 48 hours after breathing overexposure, as pulmonary edema may be delayed. As first aid for pulmonary edema, a doctor or authorized paramedic may consider administering a drug or other inhalation therapy.


UN1760 Corrosive liquids, n.o.s., Hazard class: 8; Labels: 8-Corrosive material.

Purification Methods

Distil it from 3A molecular sieves, retaining the middle fraction. It has been prepared by reduction of hexafluoroacetone in tetrahydrofuran (THF), In this case hexafluoropropanol forms a stable 1:1 complex which distils at 99-100o/760mm (n 25 1.3283), The complex is decomposed by mixing with 20% oleum and distilling in a vacuum, and the distillate is redistilled to give pure hexafluoropropan-2-ol with b 59o/760mm. The 1H NMR shows a doublet at 4.52ppm (JH,H 2Hz). The benzoyl derivative, [10315-85-2] M 272.1, has m 53.9o after crystalllisation from pentane at -50o, and its IR has at 1760cm-1. [Middleton & Lindsey J Am Chem Soc 86 4948 1964, Urry et al. J Org Chem 32 347 1967.] It has very high peptide solubilising properties, alone or with CH2Cl2 [use as a solvent: Narita et al. Bull Chem Soc Jpn 61 281 1988, Biochemistry 29 2639 1990.] It is CORROSIVE, causes severe eye irritation.


HFIP is incompatible with acids, acid chlorides, and oxidizing agents.

Waste Disposal

May be incinerated. In accor dance with 40CFR165, follow recommendations for the disposal of pesticides and pesticide containers. Must be dis posed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste contain ing this contaminant (≥100 kg/mo) must conform to EPA regulations governing storage, transportation, treatment, and waste disposal.

1,1,1,3,3,3-Hexafluoro-2-propanol Preparation Products And Raw materials

Raw materials

Preparation Products

1,1,1,3,3,3-Hexafluoro-2-propanol Suppliers

Global( 327)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Jinan Finer Chemical Co., Ltd
+86-531-88989539 CHINA 479 58
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 China 19954 60
Henan DaKen Chemical CO.,LTD.
+86-371-55531817 CHINA 22043 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 20786 55
Shanghai Time Chemicals CO., Ltd.
+86-021-57951555 CHINA 1374 55
Mainchem Co., Ltd.
+86-0592-6210733 CHINA 32651 55
Hangzhou FandaChem Co.,Ltd.
0086 158 5814 5714 (Mobile; WhatsApp; Telegram)
+86-571-56059825 CHINA 2444 55
Fluoropharm Co., Ltd.
+8613336034509 CHINA 735 60
+86 18953170293
+86 0531-67809011 CHINA 521 58
Chemwill Asia Co.,Ltd.
86-21-51861608;;; CHINA 24118 58

View Lastest Price from 1,1,1,3,3,3-Hexafluoro-2-propanol manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-16 1,1,1,3,3,3-Hexafluoro-2-propanol
US $8.00 / kg 1kg 98% 10MT career henan chemical co
2019-03-26 High quality D-Biotin 99% with best price
US $10.00 / kg 100 gg 99.9% 20TONS Hebei Jimi Trading Co., Ltd.
2019-03-26 High quality Sericin with best price cas:60650-89-7
US $80.00-100.00 / kg 100 gg 99.9% 20TONS Hebei Jimi Trading Co., Ltd.

1,1,1,3,3,3-Hexafluoro-2-propanol Spectrum

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