ChemicalBook >> CAS DataBase List >>(R)-4-(1-aMinoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzaMide dihydrochloride

(R)-4-(1-aMinoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzaMide dihydrochloride

(R)-4-(1-aMinoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzaMide dihydrochloride structure

CAS No.: 173897-44-4

Chemical Name:: (R)-4-(1-aMinoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzaMide dihydrochloride

Synonyms: Y-33075 HCl;Y 39983 2HCL;Y-33075 2HCl;Y 39983, 2 HCl salt;Y39983 HYDROCHLORIDE;Y39983 dihydrochlortide;Y-33075 (dihydrochloride);(R)-4-(1-aMinoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzaMide dihydrochloride;Y33075 dihydrochloride,ROCK,Y33075,Y 33075,ROK,Rho-associated kinase,Inhibitor,Rho-associated protein kinase,Y 33075 dihydrochloride,Rho-kinase,inhibit,Y-33075

CBNumber:: CB32554140

Molecular Formula:: C16H18Cl2N4O

Molecular Weight:: 353.24632

MDL Number:: MFCD00945328

MOL File:: 173897-44-4.mol

MSDS File:: SDS

Last updated:2023-09-04 15:51:00

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(R)-4-(1-aMinoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzaMide dihydrochloride Properties

storage temp.	Inert atmosphere,Room Temperature
solubility	Soluble in DMSO

(R)-4-(1-aMinoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzaMide dihydrochloride price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	A594890	Y-39983Hydrochloride	173897-44-4	2.5mg	$220	2021-12-16	Buy
ChemScene	CS-0096	Y-33075dihydrochloride 97.34%	173897-44-4	10mg	$240	2021-12-16	Buy
ApexBio Technology	B1176	Y-39983dihydrochloride	173897-44-4	10mg	$315	2021-12-16	Buy
American Custom Chemicals Corporation	KIN0002446	(R)-4-(1-AMINOETHYL)-N-(1H-PYRROLO[2,3-B]PYRIDIN-4-YL)BENZAMIDE DIHYDROCHLORIDE 95.00%	173897-44-4	5MG	$497.43	2021-12-16	Buy
ChemScene	CS-0096	Y-33075dihydrochloride 97.34%	173897-44-4	5mg	$144	2021-12-16	Buy

Product number	Packaging	Price	Buy
A594890	2.5mg	$220	Buy
CS-0096	10mg	$240	Buy
B1176	10mg	$315	Buy
KIN0002446	5MG	$497.43	Buy
CS-0096	5mg	$144	Buy

(R)-4-(1-aMinoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzaMide dihydrochloride Chemical Properties,Uses,Production

Uses

Y-39983 Hydrochloride contain Rho kinase inhibitory activity.

Biological Activity

y-39983 dihydrochloride is a novel and selective inhibitor of rock family with ic50 value of 3.6nm for rock [1].y-39983 dihydrochloride has shown a selective inhibitor of rho-associated coiled coil-forming protein kinase( rock ) with ic50 values of 3.6nm, 0.42μm and 0.81μm for rock, pkc and camkii, respectively [1]. apart from these, y-39983 has been reported to relax the ciliary arteries of precontracted isolated rabbit in vitro. in addition, y-39983 has been found to increase optic-nerve-head blood flow by laser speckle flowmetry [2]. moreover, y-39983 lowered the intraocular pressure ( iop) in a dose-dependent fashion in the eyes of rabbits and monkeys [1].

References

[1] tokushige h1, inatani m, nemoto s, sakaki h, katayama k, uehata m, tanihara h. effects of topical administration of y-39983, a selective rho-associated protein kinase inhibitor, on ocular tissues in rabbits and monkeys. invest ophthalmol vis sci. 2007 jul;48(7):3216-22.
[2] watabe h1, abe s, yoshitomi t. effects of rho-associated protein kinase inhibitors y-27632 and y-39983 on isolated rabbit ciliary arteries. jpn j ophthalmol. 2011 jul;55(4):411-7. doi: 10.1007/s10384-011-0048-9. epub 2011 jun 11.

(R)-4-(1-aMinoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzaMide dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

(R)-4-(1-aMinoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzaMide dihydrochloride Suppliers

Global( 54)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3136	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8474	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131981	58
Chembest Research Laboratories Limited	021-20908456	sales@BioChemBest.com	China	6011	61
Shanghai T&W Pharmaceutical Co., Ltd.	+86 21 61551611		China	9901	58
Cantotech Chemicals, Ltd.	86-0755-86635001	cantotech@126.com	China	4576	55

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
TargetMol Chemicals Inc.	58
Nantong HI-FUTURE Biology Co., Ltd.	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
LEAPCHEM CO., LTD.	58
Aladdin Scientific	58
Amadis Chemical Company Limited	58
Chembest Research Laboratories Limited	61
Shanghai T&W Pharmaceutical Co., Ltd.	58
Cantotech Chemicals, Ltd.	55

(R)-4-(1-aMinoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzaMide dihydrochloride Spectrum

(R)-4-(1-aMinoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzaMide dihydrochloride(173897-44-4)¹HNMR

173897-44-4((R)-4-(1-aMinoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzaMide dihydrochloride)Related Search:

Y27632 (hydrochloride) N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-HYDROXYACETAMIDE Y320 (R)-4-(1-Aminoethyl)-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide Y-27632 DIHYDROCHLORIDE

(R)-4-(1-aMinoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzaMide dihydrochloride Y-33075 (dihydrochloride) Y 39983 2HCL Y 39983, 2 HCl salt Y-33075 2HCl Y39983 HYDROCHLORIDE Y-33075 HCl Y39983 dihydrochlortide Y33075 dihydrochloride,ROCK,Y33075,Y 33075,ROK,Rho-associated kinase,Inhibitor,Rho-associated protein kinase,Y 33075 dihydrochloride,Rho-kinase,inhibit,Y-33075 173897-44-4 C16H18Cl2N4O