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BML-286

CAS No.
294891-81-9
Chemical Name:
BML-286
Synonyms
BML-286;2-[[3-[(phenylacetyl)aMino]benzoyl]aMino]benzoic Acid;2-[[3-[(2-phenylacetyl)aMino]benzoyl]aMino]benzoic Acid;Benzoic acid, 2-[[3-[(2-phenylacetyl)amino]benzoyl]amino]-;Dvl-PDZ Domain Inhibitor II - CAS 294891-81-9 - Calbiochem
CBNumber:
CB32557989
Molecular Formula:
C22H18N2O4
Molecular Weight:
374.39
MDL Number:
MOL File:
294891-81-9.mol
MSDS File:
SDS
Last updated:2023-05-04 17:34:37

BML-286 Properties

storage temp. +2C to +8C
form White solid

BML-286 price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 322338 Dvl-PDZ Domain Inhibitor II - CAS 294891-81-9 - Calbiochem 294891-81-9 10mg $144 2024-03-01 Buy
TRC B595870 BML-286 294891-81-9 50mg $165 2021-12-16 Buy
Usbiological 004331 BML-286 294891-81-9 50mg $460 2021-12-16 Buy
Product number Packaging Price Buy
322338 10mg $144 Buy
B595870 50mg $165 Buy
004331 50mg $460 Buy

BML-286 Chemical Properties,Uses,Production

Uses

BML-286 is a small molecule inhibitor of the PDZ domain of Dishevelled (Dvl): an essential protein in the Wnt signaling pathways. This compound reduced the levels of apoptosis in the hyaloid vessels of the eye and also suppressed the growth of prostate cancer PC-3 cells. It is a useful tool for studies dissecting the Wnt signaling pathways.

Definition

ChEBI: 2-[[oxo-[3-[(1-oxo-2-phenylethyl)amino]phenyl]methyl]amino]benzoic acid is a member of benzamides.

General Description

A cell-permeable amidobenzanilide compound that disrupts Fz-Dvl (frizzled-dishevelled) interaction by targeting the PDZ domain (Kd = 10.6 μM) of Dvl, blocking Wnt3a-induced (10 ng/ml) transcription activity (~50% inhibition at 3 μM in 293 cell SuperTopflash reporter assays) and suppressing the Wnt pathway-dependent growth of prostate cancer PC-3 cells (by 16% in 72 h at ≥50 μM; IC50 = 12.5 μM). Shown to effectively prevent Wnt3A mRNA injection-induced xenopus embryo deformation (effective conc. = 25 μM) and suppress Wnt pathway-mediated apoptosis of the hyaloid vescular endothelial cells in the mouse eyes via vitreous injection (144 fmol/120 nl/eye) in vivo.

BML-286 Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 21)Suppliers
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 010-82848833 400-666-7788 jkinfo@jkchemical.com China 96815 76
Chemsky (shanghai) International Co.,Ltd 021-50135380 shchemsky@sina.com China 15421 60
Shanghai TaoSu Biochemical Technology Co., Ltd. 021-33632979 info@tsbiochem.com China 8073 58
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51471 80
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9709 58
Shenzhen Polymeri Biochemical Technology Co., Ltd. +86-400-002-6226 13028896684 sales@rrkchem.com China 55477 58
Energy Chemical 021-58432009 400-005-6266 marketing@energy-chemical.com China 44941 58
Changzhou Furuisi Biotechnology Co., Ltd 0519-85524369 3477467573@qq.com China 8618 58
2-[[3-[(2-phenylacetyl)aMino]benzoyl]aMino]benzoic Acid 2-[[3-[(phenylacetyl)aMino]benzoyl]aMino]benzoic Acid BML-286 Dvl-PDZ Domain Inhibitor II - CAS 294891-81-9 - Calbiochem Benzoic acid, 2-[[3-[(2-phenylacetyl)amino]benzoyl]amino]- 294891-81-9 Aromatics Inhibitors Intermediates & Fine Chemicals Pharmaceuticals Aromatics, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals