Glutaminase C-IN-1
- CAS No.
- 311795-38-7
- Chemical Name:
- Glutaminase C-IN-1
- Synonyms
- CS-2083;GLS-IN-968;Compound 968;GAC Inhibitor 968;Glutaminase C-IN-1;Glutaminase C-IN-1 (968);Glutaminase C inhibitor 1;glutaminase inhibitor 968;Glutaminase Inhibitor Compound 968;Glutaminase Inhibitor 968 >=98% (HPLC)
- CBNumber:
- CB32561506
- Molecular Formula:
- C27H27BrN2O
- Molecular Weight:
- 475.42
- MDL Number:
- MFCD00606231
- MOL File:
- 311795-38-7.mol
- MSDS File:
- SDS
| Boiling point | 623.2±55.0 °C(Predicted) |
|---|---|
| Density | 1.39±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Soluble in DMSO (up to 11 mg/ml) or in Ethanol (up to 1 mg/ml with warming) |
| pka | 4.09±0.42(Predicted) |
| form | powder |
| color | white to beige |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
Glutaminase C-IN-1 price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1327 | Glutaminase Inhibitor 968 ≥98% (HPLC) | 311795-38-7 | 5MG | $115 | 2023-06-20 | Buy |
| Sigma-Aldrich | SML1327 | Glutaminase Inhibitor 968 ≥98% (HPLC) | 311795-38-7 | 25MG | $451 | 2023-06-20 | Buy |
| Cayman Chemical | 17199 | Glutaminase Inhibitor Compound 968 ≥98% | 311795-38-7 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 17199 | Glutaminase Inhibitor Compound 968 ≥98% | 311795-38-7 | 5mg | $70 | 2024-03-01 | Buy |
| Cayman Chemical | 17199 | Glutaminase Inhibitor Compound 968 ≥98% | 311795-38-7 | 10mg | $122 | 2024-03-01 | Buy |
Glutaminase C-IN-1 Chemical Properties,Uses,Production
Description
GAC Inhibitor 968 (311795-38-7) is an allosteric inhibitor of glutaminase C (GAC).1 Inhibition of GAC blocks oncogenic transformation induced by Rho GTPases in fibroblasts and B lymphoma cells with no effect on normal cells.2 Inhibits liver-type glutaminase GLS2 and suppresses breast tumor growth in vivo.3,4 Reverses acquired erlotinib resistance in non-small cell lung cancer.5
Uses
Glutaminase inhibitor 968 has been used to study the role of glutamine metabolism in macrophage activation.
Definition
ChEBI: 5-[3-bromo-4-(dimethylamino)phenyl]-2,2-dimethyl-2,3,5,6-tetrahydrobenzo[a]phenanthridin-4(1H)-one is a partially hydrogenated benzophenanthridine carrying an oxo group at C-4, geminal methyl groups at C-2 and a 3-bromo-4-(dimethylamino)phenyl group at C-5. It has a role as an EC 3.5.1.2 (glutaminase) inhibitor.
General Description
Glutaminase Inhibitor 968 belongs to the benzophenanthridinone family.
Biochem/physiol Actions
Glutaminase Inhibitor 968 is an allosteric inihibitor of the mitochondrial enzyme glutaminase C (GAC), which is overexpressed in a number of cancer cell lines. Glutaminase Inhibitor 968 shows 21% inhibition at 10 μM, 94% at 25 μM. Glutaminase Inhibitor 968 blocked human cancer cell proliferation in culture, and in inhibited tumor formation in mouse xenograft models.
storage
Store at -20°C
References
Stainecker et al. (2015), Mechanism by which a recently discovered allosteric inhibitor blocks glutamine metabolism in transformed cells; Proc. Natl. Acad. Sci. USA, 112 394 Wang et al. (2010), Targeting mitochondrial glutaminase activity inhibits oncogenic transformation; Cancer Cell, 18 207 Katt et al. (2012), Dibenzophenanthridines as inhibitors of glutaminase C and cancer cell proliferation; Cancer Ther., 11 1269 Lukey et al. (2019), Liver-Type Glutaminase GLS2 Is a Druggable Metabolic Node in Luminal-Subtype Breast Cancer; Cell Reports, 29 76 Xie et al. (2016), Inhibition of mitochondrial glutaminase activity reverses acquired erlotinib resistance in non-small cell lung cancer; Oncotarget, 7 610
Glutaminase C-IN-1 Preparation Products And Raw materials
Raw materials
Preparation Products
Glutaminase C-IN-1 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Aromsyn Co., Ltd. | +86-0571-85585865 +8613336024896 | CB@aromsyn.com | China | 19185 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| BeiJing Hwrk Chemicals Limted | 0757-86329057 18501085097 | sales3.gd@hwrkchemical.com | China | 7583 | 55 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 | info@chemlin.com.cn | China | 17938 | 64 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66099280 17798518460 | cfzhang@aikonchem.com | China | 19918 | 55 |
View Lastest Price from Glutaminase C-IN-1 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-09-05 | Glutaminase C-IN-1
311795-38-7
|
US $1.00 / KG | 1KG | 99% | Customized | Career Henan Chemical Co |
-
- Glutaminase C-IN-1
311795-38-7
- US $1.00 / KG
- 99%
- Career Henan Chemical Co