TAE226 (NVP-TAE226)
- CAS No.
- 761437-28-9
- Chemical Name:
- TAE226 (NVP-TAE226)
- Synonyms
- TAE226;CS-1694;NVP-TAE 226;TAE-226, >98%;TAE226 (NVP-TAE226);TAE226 (NVP-TAE226), >98%;TAE226 (NVP-TAE226) USP/EP/BP;TAE226; TAE-226;TAE 226;NVPTAE226;2-((5-Chloro-2-((2-methoxy-4-morpholinophenyl)-amino)pyrimidin-4-yl)amino)-N-methylbenzamide;2-[[5-Chloro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]-N-methylbenzamide
- CBNumber:
- CB32589634
- Molecular Formula:
- C23H25ClN6O3
- Molecular Weight:
- 468.94
- MDL Number:
- MFCD12031516
- MOL File:
- 761437-28-9.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
Signal word | Warning | |||||||||
Hazard statements | H302-H315-H319-H335 | |||||||||
Precautionary statements | P261-P305+P351+P338 | |||||||||
NFPA 704 |
|
TAE226 (NVP-TAE226) price More Price(31)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 17685 | NVP-TAE226 ≥98% | 761437-28-9 | 1mg | $44 | 2024-03-01 | Buy |
Cayman Chemical | 17685 | NVP-TAE226 ≥98% | 761437-28-9 | 5mg | $193 | 2024-03-01 | Buy |
Cayman Chemical | 17685 | NVP-TAE226 ≥98% | 761437-28-9 | 10mg | $321 | 2024-03-01 | Buy |
Cayman Chemical | 17685 | NVP-TAE226 ≥98% | 761437-28-9 | 25mg | $692 | 2024-03-01 | Buy |
TRC | N925910 | NVP-TAE226 | 761437-28-9 | 5mg | $255 | 2021-12-16 | Buy |
TAE226 (NVP-TAE226) Chemical Properties,Uses,Production
Description
NVP-TAE226 is an inhibitor of focal adhesion kinase (FAK; IC50 = 5.5 nM) and the related proline-rich tyrosine kinase 2-β (PYK2β; IC50 = 5 nM). It can also inhibit the insulin-like growth factor 1 receptor (IC50 = 0.16 μM) as well as the activity of its downstream target genes such as MAPK and Akt. NVP-TAE226 has been shown to inhibit glioma and ovarian tumor growth in in vivo tumor models.
Uses
NVP-TAE 226 is FAK and IGF-IR inhibitor. It can be used in biological study and therapeutic use of TAE226, a bis-?anilino pyrimidine compound, inhibits the egfr-?mutant kinase including T790M mutant to show anti-?tumor effect on EGFR-?mutant non-?small cell lung cancer cells.
Definition
ChEBI: 2-[[5-chloro-2-[2-methoxy-4-(4-morpholinyl)anilino]-4-pyrimidinyl]amino]-N-methylbenzamide is a member of morpholines.
target
PYK2
References
[1]. liu, t.j., et al., inhibition of both focal adhesion kinase and insulin-like growth factor-i receptor kinase suppresses glioma proliferation in vitro and in vivo. mol cancer ther, 2007. 6(4): p. 1357-67.
[2]. plaza-menacho, i., et al., focal adhesion kinase (fak) binds ret kinase via its ferm domain, priming a direct and reciprocal ret-fak transactivation mechanism. j biol chem, 2011. 286(19): p. 17292-302.
TAE226 (NVP-TAE226) Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29888 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49392 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 23799 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10522 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
Coresyn Pharmatech Co., Ltd. | +86-571-86626709 +86-18157142896 | cbc@coresyn.com | China | 9991 | 58 |
ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
View Lastest Price from TAE226 (NVP-TAE226) manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2019-09-06 | TAE226 (NVP-TAE226)
761437-28-9
|
US $1.00 / KG | 1KG | 98% | 20kg | Career Henan Chemical Co |
- TAE226 (NVP-TAE226)
761437-28-9
- US $1.00 / KG
- 98%
- Career Henan Chemical Co