Tubastatin A hydrochloride
- CAS No.
- 1310693-92-5
- Chemical Name:
- Tubastatin A hydrochloride
- Synonyms
- TSA HCl;CS-1894;Tubastatin A HCl salt;Tubastatin A HCl, >=98%;Tubastatin A hydrochloride;TUBASTATIN A HYDROCHLORIDE;TSA HCL;Tubastatin A HCl (AG-CR-13900, TubA);Tubastatin A hydrochloride ISO 9001：2015 REACH;Tubastatin A Hydrochloride (Also See: T897000);Tubastatin A HCl, 98%, a potent and selective HDAC6 inhibitor
- CBNumber:
- CB32589694
- Molecular Formula:
- C20H22ClN3O2
- Molecular Weight:
- 371.87
- MDL Number:
- MFCD20488052
- MOL File:
- 1310693-92-5.mol
- MSDS File:
- SDS
| Melting point | >221°C (subl.) |
|---|---|
| storage temp. | -20°C |
| solubility | Soluble in DMSO or Water. |
| form | powder |
| color | white to tan |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months. |
| FDA UNII | UHCM2AYJVX |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
| WGK Germany | 3 |
| HS Code | 29339900 |
Tubastatin A hydrochloride price More Price(27)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0044 | Tubastatin A hydrochloride ≥98% (HPLC) | 1310693-92-5 | 5mg | $210 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0044 | Tubastatin A hydrochloride ≥98% (HPLC) | 1310693-92-5 | 25mg | $805 | 2024-03-01 | Buy |
| TCI Chemical | T3687 | Tubastatin A Hydrochloride | 1310693-92-5 | 25MG | $190 | 2024-03-01 | Buy |
| TCI Chemical | T3687 | Tubastatin A Hydrochloride | 1310693-92-5 | 100MG | $580 | 2024-03-01 | Buy |
| Tocris | 6270 | Tubastatin A hydrochloride ≥98%(HPLC) | 1310693-92-5 | 10 | $126 | 2021-12-16 | Buy |
Tubastatin A hydrochloride Chemical Properties,Uses,Production
Description
Tubastatin A (1310693-92-5) is a potent and highly selective inhibitor of HDAC6 (IC50?= 15 nM, >1000-fold selectivity against other HDAC isoforms, approx. 60-fold versus HDAC8).1?It displayed anti-inflammatory and anti-rheumatic effects in Freund’s competitive adjuvant induced animal model of inflammation.2?Tubastatin A inhibited TNF-α (IC50?= 272 nM) and IL-6 (IC50 = 712 nM) in LPS stimulated human THP-1 macrophages.2?Tubastatin A has also been shown to have therapeutic potential for treatment of Alzheimer’s disease via altered amyloid-β load and reduced tau hyperphosphorylation.3-5
Uses
Tubastatin A Hydrochloride is an LSD1 inhibitor, which targets SOX2-expressing cancer cells.
Uses
Tubastatin A Hydrochloride is a neuroprotective HDAC6 inhibitor and is also known to induce hyperacetylation in primary cortical neuron cultures.
Biochem/physiol Actions
Tubastatin A increases the total numbers of mitochondria and restores the number of moving mitochondria in DRG neurons. It reverses the axonal loss in peripheral neurons in mouse model of Charcot-Marie-Tooth disease. Tubastatin A inhibits the deacetylation of α-tubulin in murine myoblasts.
target
HDAC6
storage
Store at -20°C
References
1) Butler?et al. (2010),?Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, tubastatin A; J. Am. Chem. Soc.,?132?10842 2) Vishwakarma?et al. (2013),?Tubastatin, a selective histone deacetylase 6 inhibitor shows anti-inflammatory and anti-rheumatic effects; Int. Immunopharmacol.,?16?72 3) Noack and Richter-Landsberg (2014),?HDAC6 inhibition results in tau acetylation and modulates tau phosphorylation and degradation in oligodendrocytes; Glia,?62?535 4) Selenica?et al. (2014),?Histone deacetylase 6 inhibition improves memory and reduces total tau levels in a mouse model of tau deposition; Alzheimers Res.Ther.,?6?12 5) Zhang?et al. (2014)?Tubastatin A/ACY-1215 improves cognition in Alzheimer’s disease transgenic mice; J. Alzheimers Dis.,?41?1193
Tubastatin A hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23556 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29271 | 58 |
| Chemia Biotechnology（Shanghai） Co., Ltd | +8613816753574 | info@chemia-pharm.com | CHINA | 311 | 58 |
| Finetech Industry Limited | +86-27-87465837 +8618971612321 | info@finetechnology-ind.com | China | 9702 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
View Lastest Price from Tubastatin A hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-09-29 | Tubastatin A hydrochloride
1310693-92-5
|
US $1.10 / g | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2019-12-23 | Tubastatin A HCl
1310693-92-5
|
US $1.00 / KG | 1g | Min98% HPLC | g/kg /ton | Career Henan Chemical Co |
-
- Tubastatin A hydrochloride
1310693-92-5
- US $1.10 / g
- 99.00%
- Dideu Industries Group Limited
-
- Tubastatin A HCl
1310693-92-5
- US $1.00 / KG
- Min98% HPLC
- Career Henan Chemical Co
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