TC-N 1752
- CAS No.
- 1211866-85-1
- Chemical Name:
- TC-N 1752
- Synonyms
- TC-N 1752;TC-N 1752-d5;Nav1.7 blocker 52;TCN 1752,TC N 1752;TC-N 1752, 10 mM in DMSO;N-(2-Methyl-3-((4-(4-((4-(trifluoromethoxy)benzyl)oxy)piperidin-1-yl)-1,3,5-triazin-2-yl)amino)phenyl)acetamide;N-[2-METHYL-3-[[4-[4-[[4-(TRIFLUOROMETHOXY)PHENYL]METHOXY]-1-PIPERIDINYL]-1,3,5-TRIAZIN-2-YL]AMINO]PHENYL]ACETAMIDE;AcetaMide, N-[2-Methyl-3-[[4-[4-[[4-(trifluoroMethoxy)phenyl]Methoxy]-1-piperidinyl]-1,3,5-triazin-2-yl]aMino]phenyl]-
- CBNumber:
- CB32603006
- Molecular Formula:
- C25H27F3N6O3
- Molecular Weight:
- 516.52
- MDL Number:
- MOL File:
- 1211866-85-1.mol
| Product description | Number | Pack Size | Price |
| TC-N1752 ≥99%(HPLC) | 4435 | 10 | $261 |
| TC-N1752 ≥99%(HPLC) | 4435 | 50 | $1040 |
| TC-N1752 | T126035 | 10mg | $240 |
| TC-N 1752 | 256851 | 10mg | $516 |
| TCN-1752 99.00% | INB0001547 | 5MG | $532 |
TC-N 1752 price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Tocris | 4435 | TC-N1752 ≥99%(HPLC) | 1211866-85-1 | 10 | $261 | 2021-12-16 | Buy |
| Tocris | 4435 | TC-N1752 ≥99%(HPLC) | 1211866-85-1 | 50 | $1040 | 2021-12-16 | Buy |
| TRC | T126035 | TC-N1752 | 1211866-85-1 | 10mg | $240 | 2021-12-16 | Buy |
| Usbiological | 256851 | TC-N 1752 | 1211866-85-1 | 10mg | $516 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0001547 | TCN-1752 99.00% | 1211866-85-1 | 5MG | $532 | 2021-12-16 | Buy |
TC-N 1752 Chemical Properties,Uses,Production
Uses
TC-N 1752 is a potent, state-dependent inhibitor of Nav1.7, which is a neuronal voltage gated sodium channel and a critical mediator of pain sensitization.
in vivo
TC-N 1752 (compound 52) (3-30 mg/kg; p.o.) dose-dependently shows analgesic effect in the Formalin model[1].
TC-N 1752 (3-30 mg/kg; p.o.) decreases thermal hyperalgesia produced by inflammation[3].
TC-N 1752 (5 mg/mL; 500 μL; i.v.) attenuates complete Freund’s adjuvant (CFA)-induced sensitization of C-fiber nociceptors[3].
| Animal Model: | Rats were injected intraplantar with Formalin[1] |
| Dosage: | 3, 10, 20, 30 mg/kg |
| Administration: | Administered p.o. 120 min prior to Formalin |
| Result: | Showed analgesic efficacy starting at the dose of 3 mg/kg, with full efficacy at 20 mg/kg dose. |
IC 50
hNav1.7: 0.17 μM (IC50); hNav1.8: 0.1 μM (IC50); hNav1.3: 0.3 μM (IC50); hNav1.4: 0.4 μM (IC50); hNav1.5: 1.1 μM (IC50)
storage
+4°C
TC-N 1752 Preparation Products And Raw materials
Raw materials
Preparation Products
TC-N 1752 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32435 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| Bide Pharmatech Ltd. | 400-164-7117 13681763483 | product02@bidepharm.com | China | 39966 | 60 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8447 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
| Jinan Yaoyan Pharmaceutical Co., Ltd. | jnyaoyan@163.com | China | 3069 | 58 | |
| Nanjing Meihao Pharmaceutical Technology Co., Ltd. | meitaochem@126.com | meitaochem@126.com | China | 19103 | 58 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
| Jinan ponder chemical co. LTD | 0531-0000 | thinklifescience@163.com | China | 19689 | 58 |
