Apatinib Mesylate
- CAS No.
- 1218779-75-9
- Chemical Name:
- Apatinib Mesylate
- Synonyms
- Apatinib Mesylate;YN 968D1;Rivoceranib (Apatinib);Apatinib methanesulfonate;Apatinib Mesylate(YN968D1);Apatinib (YN968D1) mesylate;Protein Tyrosine Kinase Inhibitors;Pyrazino[2,3-f][1,14]phenanthroline;N-[4-(1-cyanocyclopentyl)phenyl]-2-[(4-methylpyridin-3-yl)amino]pyridine-3-carboxamide;N-(4-(1-cyanocyclopentyl)phenyl)-2-((pyridin-4-ylmethyl)amino)nicotinamide methanesulfonate
- CBNumber:
- CB32614349
- Molecular Formula:
- C25H27N5O4S
- Molecular Weight:
- 493.58
- MDL Number:
- MOL File:
- 1218779-75-9.mol
- MSDS File:
- SDS
| storage temp. | Store at -20°C |
|---|---|
| solubility | ≥49.4 mg/mL in DMSO; insoluble in H2O; ≥2.17 mg/mL in EtOH with gentle warming and ultrasonic |
| form | solid |
| Water Solubility | Water: Insoluble |
| FDA UNII | TK02X14ASJ |
Apatinib Mesylate price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth Carbosynth | FA145494 | Apatinib mesylate | 1218779-75-9 | 10mg | $100 | 2021-12-16 | Buy |
| ApexBio Technology | B2303 | Apatinib | 1218779-75-9 | 5mg | $128 | 2021-12-16 | Buy |
| ApexBio Technology | B2303 | Apatinib | 1218779-75-9 | 10mM(in 1mL DMSO) | $130 | 2021-12-16 | Buy |
| ApexBio Technology | B2303 | Apatinib | 1218779-75-9 | 10mg | $143 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA145494 | Apatinib mesylate | 1218779-75-9 | 25mg | $200 | 2021-12-16 | Buy |
Apatinib Mesylate Chemical Properties,Uses,Production
Biological Activity
apatinib （yn968d1）is a potent inhibior of the vegf signaling pathway with the ic50 value of 1nm for vegfr-2 in in vitro enzyme experiments [1]..
in vitro
apatinib has shown the inhibition of tyrosine kinase activities with the ic50 values of 0.013μm, 0.429μm and 0.53μm for ret, c-kit and c-src, respectively. in addition, apatinib has been revealed to have no significant effects in egfr, her-2 or fgfr1 in concentrations up to 10μm. apart from these, apatinib has been reported to inhibit the growth factor-stimulated receptor phosphorylation at the cellular level. furthermore, apatinib has also reported to slightly inhibitor proliferation of huvec by 20% fbs with the ic50 value of 23.4μm and significantly inhibit stimulated by 20ng/ml vegf with the ic50 value of 0.17μm. once-daily oral administration of apatinib has been noted to produce a dose-dependent inhibition of tumor growth in human tumor xenografts in immunodeficient mice [1]
References
[1] tian s1, quan h, xie c, guo h, lü f, xu y, li j, lou l. yn968d1 is a novel and selective inhibitor of vascular endothelial growth factor receptor-2 tyrosine kinase with potent activity in vitro and in vivo. cancer sci. 2011 jul;102(7):1374-80.
Apatinib Mesylate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3012 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569266 15319487004 | 1015@dideu.com | China | 2263 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23556 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29271 | 58 |
View Lastest Price from Apatinib Mesylate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
![N-[4-(1-Cyanocyclopentyl)phenyl]-2-[(4-pyridinylmethyl)amino]-3-pyridinecarboxamide methanesulfonate pictures](/ProductImageEN/2022-08/Small/c2d831c8-9763-4788-9c1d-13e8c177defa.jpg) |
2022-09-01 | N-[4-(1-Cyanocyclopentyl)phenyl]-2-[(4-pyridinylmethyl)amino]-3-pyridinecarboxamide methanesulfonate
1218779-75-9
|
US $1.10 / g | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2020-02-26 | Apatinib mesylate
1218779-75-9
|
US $0.00-0.00 / KG | 1KG | 99.0%+ | 100 tons | Shaanxi Dideu Medichem Co. Ltd | |
![N-[4-(1-Cyanocyclopentyl)phenyl]-2-[(4-pyridinylmethyl)amino]-3-pyridinecarboxamide methanesulfonate pictures](https://img.chemicalbook.com/ProductImageEN/2018-12/Small/0d29a12c-2ca6-431a-b0b8-b91eca49647d.png) |
2019-07-06 | N-[4-(1-Cyanocyclopentyl)phenyl]-2-[(4-pyridinylmethyl)amino]-3-pyridinecarboxamide methanesulfonate
1218779-75-9
|
US $2.00 / kg | 1kg | 99% | 100kg | Career Henan Chemical Co |
-
- N-[4-(1-Cyanocyclopentyl)phenyl]-2-[(4-pyridinylmethyl)amino]-3-pyridinecarboxamide methanesulfonate
1218779-75-9
- US $1.10 / g
- 99.00%
- Dideu Industries Group Limited
-
- Apatinib mesylate
1218779-75-9
- US $0.00-0.00 / KG
- 99.0%+
- Shaanxi Dideu Medichem Co. Ltd
-
- N-[4-(1-Cyanocyclopentyl)phenyl]-2-[(4-pyridinylmethyl)amino]-3-pyridinecarboxamide methanesulfonate
1218779-75-9
- US $2.00 / kg
- 99%
- Career Henan Chemical Co