BMS-265246
- CAS No.
- 582315-72-8
- Chemical Name:
- BMS-265246
- Synonyms
- CS-984;BMS-265246;BMS-265246, >=98%;BMS-265246 USP/EP/BP;BMS265246; BMS 265246;(4-Butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)(2,6-difluoro-4-methylphenyl)-methanone;Methanone, (4-butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)(2,6-difluoro-4-methylphenyl)-;(4-Butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)(2,6-difluoro-4-methylphenyl)-methanone BMS265246
- CBNumber:
- CB32624100
- Molecular Formula:
- C18H17F2N3O2
- Molecular Weight:
- 345.34
- MDL Number:
- MFCD22420825
- MOL File:
- 582315-72-8.mol
- MSDS File:
- SDS
| Boiling point | 552.9±50.0 °C(Predicted) |
|---|---|
| Density | 1.304±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | insoluble in H2O; insoluble in EtOH; ≥17.25 mg/mL in DMSO |
| form | solid |
| pka | 8.50±0.40(Predicted) |
| FDA UNII | 4GF4A623RF |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
BMS-265246 price More Price(27)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 19168 | BMS-265246 ≥95% | 582315-72-8 | 1mg | $62 | 2024-03-01 | Buy |
| Cayman Chemical | 19168 | BMS-265246 ≥95% | 582315-72-8 | 5mg | $270 | 2024-03-01 | Buy |
| Tocris | 5654 | BMS265246 ≥97%(HPLC) | 582315-72-8 | 10 | $189 | 2021-12-16 | Buy |
| Tocris | 5654 | BMS265246 ≥97%(HPLC) | 582315-72-8 | 50 | $794 | 2021-12-16 | Buy |
| Usbiological | 004336 | BMS-265246 | 582315-72-8 | 5mg | $566 | 2021-12-16 | Buy |
BMS-265246 Chemical Properties,Uses,Production
Uses
BMS-265246 is a potent and selective pyra-zolopyridine based inhibitor of cdk2/cyclinE, cdk1/cyclinB and cdk4/ cyclinD.
Biological Activity
bms265246 is a potent and selective inhibitor for cdk1 and cdk2 (ic50= 6 nm and 9 nm)cyclin-dependent kinases (cdk) are a group of serine/threonine kinases. they are activated by coupling to cyclin and participate in the regulation of cell cycle.bms265246 inhibited the cdk4/cycd activity and prevented a2780 cytox (ic50 = 0.23 μm and 0.76 μm) [1]. in hct-116 cells, bms-265246 blocked the cell proliferation (ec50= 0.293 μm—0.492 μm). following the treatment of bms-265246, low dna intensity, large round nuclei and 4n dna content were observed in the dominant cell population –g2 arrested cells. [2]
storage
Store at -20°C
References
1. misra rn, xiao hy, rawlins db et al. 1h-pyrazolo[3,4-b]pyridine inhibitors of cyclin-dependent kinases: highly potent 2,6-difluorophenacyl analogues. bioorgmed chem lett. 2003 jul 21;13(14):2405-8.2. sutherland jj, low j, blosser w et al. a robust high-content imaging approach for probing the mechanism of action and phenotypic outcomes of cell-cycle modulators. mol cancer ther. 2011 feb;10(2):242-54.
BMS-265246 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29322 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| AdooQ Bioscience CHINA | 025-58849295 18951903616; | info@adooq.cn | China | 2989 | 60 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 94838 | 76 |