Phenol, 2-Methoxy-5-[[[(1E)-2-(2,4,6-triMethoxyphenyl)ethenyl]sulfonyl]Methyl]-, 1-(dihydrogen phosphate)
![Phenol, 2-Methoxy-5-[[[(1E)-2-(2,4,6-triMethoxyphenyl)ethenyl]sulfonyl]Methyl]-, 1-(dihydrogen phosphate) Structure](CAS/20150408/GIF/865783-99-9.gif)
- CAS No.
- 865783-99-9
- Chemical Name:
- Phenol, 2-Methoxy-5-[[[(1E)-2-(2,4,6-triMethoxyphenyl)ethenyl]sulfonyl]Methyl]-, 1-(dihydrogen phosphate)
- Synonyms
- CS-2580;ON-014185;Briciclib, >98%;Briciclib,ON-014185;Briciclib, 10 mM in DMSO;Briciclib(ON 013105,ON 014185);ON013105;ON014185;ON-013105;ON-014185;(E)-5-[[(2,4,6-Trimethoxystyryl)sulfonyl]methyl]-2-methoxyphenyl dihydrogen phosphate;Autophagy,Briciclib,Eukaryotic Initiation Factor (eIF),Inhibitor,ON014185,ON-014185,inhibit;2-Methoxy-5-({[(E)-2-(2,4,6-trimethoxyphenyl)vinyl]sulfonyl}methy l)phenyl dihydrogen phosphate
- CBNumber:
- CB32624928
- Molecular Formula:
- C19H23O10PS
- Molecular Weight:
- 474.42
- MDL Number:
- MFCD22665751
- MOL File:
- 865783-99-9.mol
Phenol, 2-Methoxy-5-[[[(1E)-2-(2,4,6-triMethoxyphenyl)ethenyl]sulfonyl]Methyl]-, 1-(dihydrogen phosphate) Properties
| storage temp. | Sealed in dry,Room Temperature |
|---|---|
| solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml |
| form | A crystalline solid |
| color | White to off-white |
| InChI | InChI=1S/C19H23O10PS/c1-25-14-10-17(27-3)15(18(11-14)28-4)7-8-31(23,24)12-13-5-6-16(26-2)19(9-13)29-30(20,21)22/h5-11H,12H2,1-4H3,(H2,20,21,22)/b8-7+ |
| InChIKey | LXENKEWVEVKKGV-BQYQJAHWSA-N |
| SMILES | C1(OP(O)(O)=O)=CC(CS(/C=C/C2=C(OC)C=C(OC)C=C2OC)(=O)=O)=CC=C1OC |
| FDA UNII | WG93X96336 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
Phenol, 2-Methoxy-5-[[[(1E)-2-(2,4,6-triMethoxyphenyl)ethenyl]sulfonyl]Methyl]-, 1-(dihydrogen phosphate) price More Price(27)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 22989 | Briciclib ≥98% | 865783-99-9 | 1mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 22989 | Briciclib ≥98% | 865783-99-9 | 5mg | $161 | 2024-03-01 | Buy |
| Cayman Chemical | 22989 | Briciclib ≥98% | 865783-99-9 | 10mg | $283 | 2024-03-01 | Buy |
| Cayman Chemical | 22989 | Briciclib ≥98% | 865783-99-9 | 25mg | $573 | 2024-03-01 | Buy |
| TRC | B637925 | Briciclib | 865783-99-9 | 100mg | $580 | 2021-12-16 | Buy |
Phenol, 2-Methoxy-5-[[[(1E)-2-(2,4,6-triMethoxyphenyl)ethenyl]sulfonyl]Methyl]-, 1-(dihydrogen phosphate) Chemical Properties,Uses,Production
Description
Briciclib is a water soluble derivative of ON 013100, a small molecule that binds to and inhibits eukaryotic translation initiation factor 4E (eIF4E). Briciclib inhibits proliferation of JEKO-1 and Mino mantle cell leukemia (MCL), MCF-7 and MDA-MB-231 breast, AGS gastric, and OE19, OE33, and LFO-1 esophageal cancer cell lines with GI50 values ranging from 9.8 to 12.2 nM. It reduces expression of cyclin D1 and c-Myc, markers of eIF4E activity, in breast and MCL cancer cell lines in a dose-dependent manner. Briciclib also induces expression of the pro-apoptotic proteins p53 and cleaved caspase-3.
Uses
Briciclib is a useful organic intermediate employed in the synthesis of [[(phenylmethyl)sulfonyl]ethenyl]benzene derivatives with anticancer activity.
IC 50
eIF4
Phenol, 2-Methoxy-5-[[[(1E)-2-(2,4,6-triMethoxyphenyl)ethenyl]sulfonyl]Methyl]-, 1-(dihydrogen phosphate) Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 32367 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30230 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38795 | 58 | |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| MQ (shanghai) Pharmaceuticals Co., Ltd. | 13761635123 | 1014988033@qq.com | China | 4913 | 55 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2922 | 55 |
