BMS 665053
- CAS No.
- 1173435-64-7
- Chemical Name:
- BMS 665053
- Synonyms
- BMS 665053;BMS-665053 >=98% (HPLC);5-chloro-1-[(1S)-1-cyclopropylethyl]-3-[2,6-dichloro-4-(difluoromethoxy)anilino]pyrazin-2-one;2(1H)-Pyrazinone, 5-chloro-1-[(1S)-1-cyclopropylethyl]-3-[[2,6-dichloro-4-(difluoromethoxy)phenyl]amino]-
- CBNumber:
- CB32627611
- Molecular Formula:
- C16H14Cl3F2N3O2
- Molecular Weight:
- 424.66
- MDL Number:
- MFCD28977961
- MOL File:
- 1173435-64-7.mol
Last updated:2023-04-23 13:52:06
BMS 665053 price More Price(2)
BMS 665053 Chemical Properties,Uses,Production
Biochem/physiol Actions
BMS-665053 is a pyrazinone-containing antagonist that targets corticotropin-releasing factor/hormone (CRF or CRH) receptor 1 (CRF1, CRF-R1, CRFR-1, CRH-R1, CRHR-1) with high affinity (IC50 10 μM against 150 pM ovine CRF in binding assay). BMS-665053 exhibits anxiolytic efficacy in a defensive withdrawal anxiety test in rats in vivo (10 mg/kg p.o.) with good oral bioavailability (F = 52%).
BMS 665053 Preparation Products And Raw materials
Raw materials
Preparation Products
BMS 665053 Suppliers
Global( 5)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44894 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24131 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| Sigma-Aldrich | 80 |
| Energy Chemical | 58 |
| TargetMol Chemicals Inc. | 58 |
BMS 665053
5-chloro-1-[(1S)-1-cyclopropylethyl]-3-[2,6-dichloro-4-(difluoromethoxy)anilino]pyrazin-2-one
2(1H)-Pyrazinone, 5-chloro-1-[(1S)-1-cyclopropylethyl]-3-[[2,6-dichloro-4-(difluoromethoxy)phenyl]amino]-
BMS-665053 >=98% (HPLC)
1173435-64-7
C16H14Cl3F2N3O2