ChemicalBook >> CAS DataBase List >>MK 0557
MK 0557
- CAS No.
- 328232-95-7
- Chemical Name:
- MK 0557
- Synonyms
- MK 0557;CS-2471;MK0557;MK 0557;MK0557,Neuropeptide Y Receptor,inhibit,MK 0557,Inhibitor,NPY receptor,MK-0557;N'-Dicyanomethylene-N-(2,4,5-trichloro-phenyl)-hydrazinecarboxylic acid ethyl ester;N-[1-(2-fluorophenyl)pyrazol-3-yl]-1'-oxospiro[cyclohexane-4,3'-furo[3,4-c]pyridine]-1-carboxamide;trans-N-[1-(2-Fluorphenyl)-1H-pyrazol-3-yl]-1'-oxospiro[cyclohexane-1,3'(1'H)-furo[3,4-c]pyridine]-4-carboxamide;trans-N-(1-(2-Fluorophenyl)-1H-pyrazol-3-yl)-1'-oxo-1'H-spiro[cyclohexane-1,3'-furo[3,4-c]pyridine]-4-carboxamide;trans-N-(1-(2-Fluorophenyl)-1H-pyrazol-3-yl)-1'-oxo-1'H-spiro[cyclohexane-1,3'-furo[3,4-c]pyridine]-4-carboxamide;(1r,4r)-N-(1-(2-fluorophenyl)-1H-pyrazol-3-yl)-1'-oxo-1'H-spiro[cyclohexane-1,3'-furo[3,4-c]pyridine]-4-carboxamide
- CBNumber:
- CB32628133
- Molecular Formula:
- C22H19FN4O3
- Molecular Weight:
- 406.41
- MDL Number:
- MFCD25976714
- MOL File:
- 328232-95-7.mol
- MSDS File:
- SDS
Last updated:2024-07-02 08:55:06
Melting point | 240.0-240.6 °C |
---|---|
Boiling point | 708.7±60.0 °C(Predicted) |
Density | 1.46±0.1 g/cm3(Predicted) |
storage temp. | Store at -20°C |
solubility | DMF: 5 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 3 mg/ml |
form | A crystalline solid |
pka | 13.40±0.20(Predicted) |
color | White to off-white |
FDA UNII | HVE36P8422 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302-H315-H319-H335 |
Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501 |
MK 0557 price More Price(13)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 22134 | MK-0557 ≥98% | 328232-95-7 | 1mg | $37 | 2024-03-01 | Buy |
Cayman Chemical | 22134 | MK-0557 ≥98% | 328232-95-7 | 5mg | $161 | 2024-03-01 | Buy |
Cayman Chemical | 22134 | MK-0557 ≥98% | 328232-95-7 | 10mg | $283 | 2024-03-01 | Buy |
Cayman Chemical | 22134 | MK-0557 ≥98% | 328232-95-7 | 25mg | $618 | 2024-03-01 | Buy |
ChemScene | CS-6367 | MK-0557 99.76% | 328232-95-7 | 50mg | $792 | 2021-12-16 | Buy |
MK 0557 Chemical Properties,Uses,Production
Description
MK-0557 is a potent antagonist of the neuropeptide Y (NPY) receptor Y5 (Kis = 1.3, 0.79, 0.74, and 1.4 nM for human, rhesus monkey, mouse, and rat receptors, respectively). It is >7,500-fold selective for Y5 over other receptors and lacks activity in a panel of 180 receptors, enzymes, and ion channels at concentrations up to 1 μM. MK-0557 increases intracellular calcium in CHO cells expressing the human Y5 receptor in a concentration-dependent manner. In vivo, MK-0557 (30 mg/kg) reduces body weight gain in wild-type and diet-induced obese mice. It also reduces retroperitoneal fat pad weight, epididymal and mesenteric fat pad weights, leptin levels, and food intake in lean mice fed a high-fat diet.
MK 0557 Preparation Products And Raw materials
Raw materials
Preparation Products
MK 0557 Suppliers
Global( 53)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29822 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10522 | 58 |
Hong Kong Tiansheng New Material Trading Co., Ltd | +8617320695765 | zxx@hktiansheng.com | China | 981 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33350 | 58 |
Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42057 | 58 |
SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | cooperation@kean-chem.com | China | 40068 | 58 |
Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
View Lastest Price from MK 0557 manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2022-02-25 | MK 0557
328232-95-7
|
US $100.00 / KG | 1KG | 98% | 100KG | Hong Kong Tiansheng New Material Trading Co., Ltd | ||
2022-02-25 | N-[1-(2-fluorophenyl)pyrazol-3-yl]-1'-oxospiro[cyclohexane-4,3'-furo[3,4-c]pyridine]-1-carboxamide
328232-95-7
|
US $100.00 / Kg/Bag | 1KG | 99% | 10kg | Hong Kong Tiansheng New Material Trading Co., Ltd | ||
2019-12-23 | trans-N-[1-(2-Fluorphenyl)-1H-pyrazol-3-yl]-1'-oxospiro[cyclohexane-1,3'(1'H)-furo[3,4-c]pyridine]-4-carboxamide
328232-95-7
|
US $1.00 / KG | 1KG | 99% | 100KG | Career Henan Chemical Co |
- MK 0557
328232-95-7
- US $100.00 / KG
- 98%
- Hong Kong Tiansheng New Material Trading Co., Ltd
- N-[1-(2-fluorophenyl)pyrazol-3-yl]-1'-oxospiro[cyclohexane-4,3'-furo[3,4-c]pyridine]-1-carboxamide
328232-95-7
- US $100.00 / Kg/Bag
- 99%
- Hong Kong Tiansheng New Material Trading Co., Ltd
- trans-N-[1-(2-Fluorphenyl)-1H-pyrazol-3-yl]-1'-oxospiro[cyclohexane-1,3'(1'H)-furo[3,4-c]pyridine]-4-carboxamide
328232-95-7
- US $1.00 / KG
- 99%
- Career Henan Chemical Co
328232-95-7(MK 0557)Related Search:
MK 0557
trans-N-[1-(2-Fluorphenyl)-1H-pyrazol-3-yl]-1'-oxospiro[cyclohexane-1,3'(1'H)-furo[3,4-c]pyridine]-4-carboxamide
(1r,4r)-N-(1-(2-fluorophenyl)-1H-pyrazol-3-yl)-1'-oxo-1'H-spiro[cyclohexane-1,3'-furo[3,4-c]pyridine]-4-carboxamide
N-[1-(2-fluorophenyl)pyrazol-3-yl]-1'-oxospiro[cyclohexane-4,3'-furo[3,4-c]pyridine]-1-carboxamide
Spiro[cyclohexane-1,3'(1'H)-furo[3,4-c]pyridine]-4-carboxamide, N-[1-(2-fluorophenyl)-1H-pyrazol-3-yl]-1'-oxo-, trans-
MK0557;MK 0557
CS-2471
N'-Dicyanomethylene-N-(2,4,5-trichloro-phenyl)-hydrazinecarboxylic acid ethyl ester
MK0557,Neuropeptide Y Receptor,inhibit,MK 0557,Inhibitor,NPY receptor,MK-0557
trans-N-(1-(2-Fluorophenyl)-1H-pyrazol-3-yl)-1'-oxo-1'H-spiro[cyclohexane-1,3'-furo[3,4-c]pyridine]-4-carboxamide
trans-N-(1-(2-Fluorophenyl)-1H-pyrazol-3-yl)-1'-oxo-1'H-spiro[cyclohexane-1,3'-furo[3,4-c]pyridine]-4-carboxamide
(1r,4r)-N-[1-(2-fluorophenyl)-1H-pyrazol-3-yl]-1'-oxo-1'H-spiro[cyclohexane-1,3'-furo[3,4-c]pyridine]-4-carboxamide
328232-95-7
28232-95-7