PNU 100480
- CAS No.
- 168828-58-8
- Chemical Name:
- PNU 100480
- Synonyms
- CS-2604;U-100480;Sutezolid;PNU 100480;PF-02341272;Sutezolid 13C4;Sutezolid (PNU-100480);Sutezolid >=98% (HPLC);PNU-100480; U-100480; PF-02341272;Sutezolid (PNU-100480, PF-02341272)
- CBNumber:
- CB32628274
- Molecular Formula:
- C16H20FN3O3S
- Molecular Weight:
- 353.41
- MDL Number:
- MFCD00937821
- MOL File:
- 168828-58-8.mol
- MSDS File:
- SDS
| Melting point | 186-187°C |
|---|---|
| Boiling point | 609.0±55.0 °C(Predicted) |
| Density | 1.321±0.06 g/cm3(Predicted) |
| storage temp. | room temp |
| solubility | DMSO: soluble20mg/mL, clear |
| form | powder |
| pka | 15.53±0.46(Predicted) |
| color | white to beige |
| optical activity | [α]/D -8 to -12°, c = 1 in chloroform-d |
| FDA UNII | 3A71182L8P |
PNU 100480 price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PZ0035 | Sutezolid ≥98% (HPLC) | 168828-58-8 | 5mg | $118 | 2024-03-01 | Buy |
| Sigma-Aldrich | PZ0035 | Sutezolid ≥98% (HPLC) | 168828-58-8 | 25mg | $483 | 2024-03-01 | Buy |
| Cayman Chemical | 28395 | PNU 100480 | 168828-58-8 | 5mg | $86 | 2024-03-01 | Buy |
| Cayman Chemical | 28395 | PNU 100480 | 168828-58-8 | 50mg | $546 | 2024-03-01 | Buy |
| Cayman Chemical | 28395 | PNU 100480 | 168828-58-8 | 10mg | $152 | 2024-03-01 | Buy |
PNU 100480 Chemical Properties,Uses,Production
Description
PNU 100480 is an oxazolidinone antibiotic that is active against multidrug resistant tuberculosis. It inhibits the growth of M. tuberculosis replicating and nonreplicating strains (MIC = ~400 ng/ml for both) and of clinical isolates that are susceptible or resistant to a combination of isoniazid , rifampin (rifampicin; ), ethambutol , and streptomycin (; MICs = ≤0.0625-0.5 mg/L). It also inhibits the growth of P. insidiosum and P. aphanidermatum clinical isolates (MICs = 4-64 μg/ml). PNU 100480 (100 mg/kg per day) decreases the number of colony forming units (CFU) in the lung in a mouse model of systemic nonreplicating M. tuberculosis infection.
Uses
Sutezolid is an oxazolidinone antibacterial agent analog. Sutezolid is a promising antimycobacterial agent (tuberculostatic).
Biochem/physiol Actions
Sutezolid (PNU 100480) is an oxazolidinone antimicrobial. Sutezolid inhibits protein synthesis by inhibiting bacterial mRNA translation. Sutezolid is being investigated for the treatment of multiple drug–resistant and extensively drug-resistant tuberculosis. The compound is a less toxic and more potent derivative of linezolid.
PNU 100480 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| HaBo Hong Kong Co., Limited. | +86-25-18512596065 | info@habotech.com | CHINA | 933 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19994 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Zhengzhou Anbu Chem Co.,Ltd | +86-0371-88006763; +8615988602810 | sales@anbuchem.com | China | 3000 | 58 |
| Supplier | Advantage |
|---|---|
| ATK CHEMICAL COMPANY LIMITED | 60 |
| HaBo Hong Kong Co., Limited. | 58 |
| BOC Sciences | 58 |
| Career Henan Chemica Co | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 58 |
| Labnetwork lnc. | 58 |
| InvivoChem | 58 |
| LEAP CHEM CO., LTD. | 58 |
| TargetMol Chemicals Inc. | 58 |
| Zhengzhou Anbu Chem Co.,Ltd | 58 |