RI-1
- CAS No.
- 415713-60-9
- Chemical Name:
- RI-1
- Synonyms
- RI-1;CS-909;RI1;RI-1;RI-1, >=98%;RAD51 inhibitor;RI-1 >=98% (HPLC);RAD51 inhibitor 1;RAD51 inhibitor RI-1;recombination,RI 1,homologous,Inhibitor,RAD51,RI-1,inhibit;3-Chloro-1-(3,4-dichlorophenyl)-4-Morpholino-1H-pyrrole-2,5-dione
- CBNumber:
- CB32628355
- Molecular Formula:
- C14H11Cl3N2O3
- Molecular Weight:
- 361.61
- MDL Number:
- MFCD00814248
- MOL File:
- 415713-60-9.mol
- MSDS File:
- SDS
| Boiling point | 483.0±45.0 °C(Predicted) |
|---|---|
| Density | 1.61 |
| storage temp. | 2-8°C |
| solubility | DMSO: soluble10mg/mL, clear |
| pka | -3.45±0.20(Predicted) |
| form | powder |
| color | yellow to orange |
| Stability | Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months. |
| FDA UNII | S8WG8ZRQ99 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
RI-1 price More Price(41)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1274 | RI-1 ≥98% (HPLC) | 415713-60-9 | 5mg | $118 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML1274 | RI-1 ≥98% (HPLC) | 415713-60-9 | 25mg | $462 | 2024-03-01 | Buy |
| Cayman Chemical | 24182 | RI-1 ≥98% | 415713-60-9 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 24182 | RI-1 ≥98% | 415713-60-9 | 5mg | $70 | 2024-03-01 | Buy |
| Cayman Chemical | 24182 | RI-1 ≥98% | 415713-60-9 | 10mg | $122 | 2024-03-01 | Buy |
RI-1 Chemical Properties,Uses,Production
Description
RI-1 (415713-60-9) is a potent and selective inhibitor of RAD51 (IC50 = 5-30 μM), a highly conserved protein that catalyzes DNA repair via homologous recombination.1 It specifically reduces gene conversion in human cells and stimulates single strand annealing. It covalently binds to Cys319 on the surface of RAD51 and disrupts protein-protein interaction. It potentiates the effect of DNA-damaging agents on tumor cells and is a novel tool for studying DNA repair in cells.2 Potentiates the killing of glioblastoma cells by ionizing radiation3 and alkylating drugs4.
Uses
RI 1 is a chemical inhibitor of RAD51, which disrupts homologous recombination in human cells.
Biochem/physiol Actions
RI-1 is a cell-permeable RAD51 inhibitor that binds covalently to the protein surface at Cysteine 319. RI-1 disrupts homologous recombination in human cells.
target
RAD51
References
1) Anand et al. (2017), Rad51-mediated double-strand break repair and mismatch correction of divergent substrates; Nature, 544 377 2) Budke et al. (2012), RI-1: a chemical inhibitor of RAD51 that disrupts homologous recombination in human cells; Nucleic Acids Res., 40 7347 3) Balbous et al. (2016), A radiosensitizing effect of RAD51 inhibition in glioblastoma stem-like cells; BMC Cancer, 16 604 4) Berte et al. (2016), Targeting Homologous Recombination by Pharmacological Inhibitors Enhances the Killing response of Glioblastoma Cells Treated with Alkylating Drugs; Mol. Cancer Ther., 15 2665
RI-1 Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Wuxi Donghe Pharmaceutical Technology Co., Ltd. | 63313187 15358055255 | 63313187@qq.com | China | 1974 | 58 |
View Lastest Price from RI-1 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-12-24 | 3-chloro-1-(3,4-dichlorophenyl)-4-morpholin-4-ylpyrrole-2,5-dione
415713-60-9
|
US $1.00 / KG | 1KG | Min98% HPLC | g/kg/ton | Career Henan Chemical Co |
-
- 3-chloro-1-(3,4-dichlorophenyl)-4-morpholin-4-ylpyrrole-2,5-dione
415713-60-9
- US $1.00 / KG
- Min98% HPLC
- Career Henan Chemical Co