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IOX2

CAS No.
931398-72-0
Chemical Name:
IOX2
Synonyms
IOX2;JICL38;CS-564;IOX 2, >=98%;IOX2(Glycine);IOX-2; IOX2; IOX 2;DesidustatImpurity1;IOX2;IOX 2;IOX-2;JICL38;(1-benzyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carbonyl)glycine;2-[(1-BENZYL-4-HYDROXY-2-OXOQUINOLINE-3-CARBONYL)AMINO]ACETIC ACID
CBNumber:
CB32638323
Molecular Formula:
C19H16N2O5
Molecular Weight:
352.34
MDL Number:
MFCD22580424
MOL File:
931398-72-0.mol
Last updated:2023-06-30 15:45:59

IOX2 Properties

Boiling point 642.8±55.0 °C(Predicted)
Density 1.470±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: soluble5mg/mL, clear (warmed)
pka 3.61±0.10(Predicted)
form powder
color white to beige
InChIKey CAOSCCRYLYQBES-UHFFFAOYSA-N

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H301
Precautionary statements  P301+P310
Hazard Codes  T
Risk Statements  25
Safety Statements  45
RIDADR  UN 2811 6.1 / PGIII
WGK Germany  3
NFPA 704
0
2 0

IOX2 price More Price(36)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML0652 IOX2 ≥98% (HPLC) 931398-72-0 5mg $119 2024-03-01 Buy
Sigma-Aldrich SML0652 IOX2 ≥98% (HPLC) 931398-72-0 25mg $481 2024-03-01 Buy
Cayman Chemical 11573 IOX2 ≥98% 931398-72-0 5mg $68 2024-03-01 Buy
Cayman Chemical 11573 IOX2 ≥98% 931398-72-0 10mg $109 2024-03-01 Buy
Cayman Chemical 11573 IOX2 ≥98% 931398-72-0 25mg $169 2024-03-01 Buy
Product number Packaging Price Buy
SML0652 5mg $119 Buy
SML0652 25mg $481 Buy
11573 5mg $68 Buy
11573 10mg $109 Buy
11573 25mg $169 Buy

IOX2 Chemical Properties,Uses,Production

Uses

IOX2 is a potent inhibitor of HIF-1α prolyl hydroxylase-2 (PHD2) with IC50 of 21 nM.

Uses

IOX2 has been used as PHD inhibitor to induce pseudo-hypoxia.

Definition

ChEBI: 2-[[[4-hydroxy-2-oxo-1-(phenylmethyl)-3-quinolinyl]-oxomethyl]amino]acetic acid is a member of quinolines.

Biological Activity

iox2 is a potent and selective inhibitor of hif-1α prolyl hydroxylase-2 (phd2) with an ic50 of 21 nm for phd2/elgn-1 in a cell-free assay, iox2 has shown >100-fold selectivity over jmjd2a, jmjd2c, jmjd2e, jmjd3, or the 2og oxygenase fih [1].phds consist three isoforms, named phd1, phd2 and phd3. phds are dioxygenases that utilize oxygen as co-substrate providing the molecular basis for the oxygen-sensing function of these enzymes. it has been reported that phds are strikingly sensitive to graded levels of hypoxia, mirroring the progressive increases in hif-1α protein and dna binding activity that are observed when cells are exposed to gradual hypoxia [2]. in rcc4 cells, iox2 inhibited hif-1α hydroxylation at 50 μm [1].

Biochem/physiol Actions

IOX2 is selective and potent inhibitor of prolyl hydroxylases (PHD). Stabilization of HIF-1R through inhibition of PHD has been examined as a potential treatment for ischemic diseases including anemia, myocardial infarction, and stroke. IOX2 is a selective inhibitor of the hypoxia inducible factor (HIF) prolyl-hydroxylases (PHD) that exhibits up-regulation of HIF1a in zebrafish. For full characterization details, please visit the IOX2 probe summary on the Structural Genomics Consortium (SGC) website.To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc

storage

Store at +4°C

References

[1] murray j k, balan c, allgeier a m, et al. dipeptidyl-quinolone derivatives inhibit hypoxia inducible factor-1α prolyl hydroxylases-1,-2, and-3 with altered selectivity[j]. journal of combinatorial chemistry, 2010, 12(5): 676-686.
[2] berra e, benizri e, ginouvès a, et al. hif prolyl‐hydroxylase 2 is the key oxygen sensor setting low steady‐state levels of hif‐1α in normoxia[j]. the embo journal, 2003, 22(16): 4082-4090.

IOX2 Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 123)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32480 60
career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29914 58
Hubei xin bonus chemical co. LTD
86-13657291602 linda@hubeijusheng.com CHINA 22968 58
BOC Sciences
+1-631-485-4226 inquiry@bocsci.com United States 19553 58
Chongqing Chemdad Co., Ltd
+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
Alchem Pharmtech,Inc.
8485655694 sales@alchempharmtech.com United States 63711 58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.
+86-021-61551413 +8618813727289 contact@trustwe.com China 5739 58
Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd
+86-86-22-87899925 +86-8618522618860 18522618860@163.com China 694 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Zhejiang J&C Biological Technology Co.,Limited
+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10523 58

View Lastest Price from IOX2 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
IOX2 pictures 2019-07-10 IOX2
931398-72-0
US $7.00 / KG 1KG 99% 100KG Career Henan Chemical Co
E6005 pictures 2019-07-10 E6005
931398-72-0
US $7.00 / KG 1KG 99% 100KG Career Henan Chemical Co
E6005 pictures 2019-07-10 E6005
947620-48-6
US $7.00 / KG 1KG 99% 100KG Career Henan Chemical Co
  • IOX2 pictures
  • IOX2
    931398-72-0
  • US $7.00 / KG
  • 99%
  • Career Henan Chemical Co
  • E6005 pictures
  • E6005
    931398-72-0
  • US $7.00 / KG
  • 99%
  • Career Henan Chemical Co
  • E6005 pictures
  • E6005
    947620-48-6
  • US $7.00 / KG
  • 99%
  • Career Henan Chemical Co

IOX2 Spectrum

931398-72-0(IOX2)Related Search:

Glycine, N-[[1,2-dihydro-4-hydroxy-2-oxo-1-(phenylmethyl)-3-quinolinyl]carbonyl]- N-[[4-Hydroxy-2-oxo-1-(phenylmethyl)-1,2-dihydro-3-quinolinyl]carbonyl]glycine IOX2 JICL38 N-[[1,2-Dihydro-4-hydroxy-2-oxo-1-(phenylmethyl)-3-quinolinyl]carbonyl]-glycine (1-benzyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carbonyl)glycine IOX 2, >=98% IOX2;IOX 2;IOX-2;JICL38 IOX2 2-(1-benzyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxaMido)acetic acid 2-[(1-BENZYL-4-HYDROXY-2-OXOQUINOLINE-3-CARBONYL)AMINO]ACETIC ACID N-[[4-Hydroxy-2-oxo-1-(phenylmethyl)-1,2-dihydro-3-quinolinyl]carbonyl]glycine IOX2(Glycine) IOX-2; IOX2; IOX 2 CS-564 DesidustatImpurity1 HIF-PH,Inhibitor,inhibit,HIF/HIF Prolyl-Hydroxylase,IOX-2,IOX2,HIFs,Hypoxia-inducible factors 931398-72-0 Inhibitors Inhibitor