GUANABENZ
- CAS No.
- 5051-62-7
- Chemical Name:
- GUANABENZ
- Synonyms
- Rexitene;nsc-68982;GUANABENZ;Callosum benzyl;GUANABENZ USP/EP/BP;Guanabenz (WY 8678);1-(2,6-DICHLOROBENZYLIDENEAMINO)GUANIDINE;n-(2,6-dichlorobenzylidene)amino]guanidine;n-(2,6-dichlorobenzylidene)-n’-amidinohydrazine;2-(2,6-Dichlorobenzylidene)hydrazine-1-carboximidamide
- CBNumber:
- CB3263851
- Molecular Formula:
- C8H8Cl2N4
- Molecular Weight:
- 231.08
- MDL Number:
- MFCD00027408
- MOL File:
- 5051-62-7.mol
| Melting point | 227-229° (dec) |
|---|---|
| Boiling point | 353.9±52.0 °C(Predicted) |
| Density | 1.49±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO: 12 mg/mL (51.93 mM);Ethanol: 15 mg/mL (64.91 mM) |
| pka | pKa 8.1 (Uncertain) |
| Water Solubility | Water: Insoluble |
| FDA UNII | GGD30112WC |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS08,GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H361-H332-H312 |
| Precautionary statements | P264-P270-P301+P312-P330-P501-P261-P271-P304+P340-P312-P280-P302+P352-P312-P322-P363-P501-P201-P202-P281-P308+P313-P405-P501 |
| Hazard Codes | Xn |
| Risk Statements | 20/21/22-62 |
| Safety Statements | 22-36/37/39 |
| RIDADR | 3249 |
| WGK Germany | 3 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
GUANABENZ price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | S762091 | N-(2,6-DICHLOROBENZYLIDENEAMINO)GUANIDINE Aldrich | 5051-62-7 | 50mg | $179 | 2024-03-01 | Buy |
| American Custom Chemicals Corporation | API0006231 | GUANABENZ 95.00% | 5051-62-7 | 5MG | $502.68 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 75138 | Guanabenz | 5051-62-7 | 5mg | $1545 | 2021-12-16 | Buy |
| CSNpharm | CSN23785 | GUANABENZ | 5051-62-7 | 100mg | $237 | 2021-12-16 | Buy |
| AHH | MT-08425 | 1-(2,6-Dichlorobenzylideneamino)guanidine 98% | 5051-62-7 | 0.1g | $306 | 2021-12-16 | Buy |
GUANABENZ Chemical Properties,Uses,Production
Description
Guanabenz is an α2-adrenergic agonist that exhibits pronounced hypotensive action, and that is associated with a reduction of overall peripheral vascular resistance, decline in frequency of cardiac contractions, and reduced cardiac output.
Originator
Wytensin,Wyeth,US,1982
Uses
It is used both independently and in combination with oral diuretics for treating various degrees of hypertension.
Uses
alpha agonists
Definition
ChEBI: Guanabenz is a dichlorobenzene.
Manufacturing Process
A mixture of 14.0 g of 2,6-dichlorobenzaldehyde, 10.8 g of aminoguanidine bicarbonate and 100 ml of pyridine was refluxed for 3 hours. The reaction mixture was poured into water and the crystalline precipitate filtered off; MP 225°C to 227°C.
Therapeutic Function
Antihypertensive
Synthesis
Guanabenz, [(2,6-dichlorobenzyliden) amino] guanidine (22.3.1), is synthesized in one step by reacting 2,6-dichlorobenzaldehyde with amino guanidine.
Purification Methods
Crystallise the guanidine from MeCN and store it in a CO2–free atmosphere. The monoHCl [23256-5-0] has m 178o(dec) [solubility w% at 25o is 1.1(H2O), 5(EtOH), 0.1(EtOAc), 0.06(CHCl3)]. It is an antihypertensive drug. [Holmes et al. Drugs 26 212 1983.]
GUANABENZ Preparation Products And Raw materials
GUANABENZ Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 9320 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29220 | 58 |
| AFINE CHEMICALS LIMITED | 0571-85134551 | info@afinechem.com | CHINA | 15377 | 58 |
| Finetech Industry Limited | +86-27-87465837 +8618971612321 | info@finetechnology-ind.com | China | 9702 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 49999 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
View Lastest Price from GUANABENZ manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-08-11 | GUANABENZ USP/EP/BP
5051-62-7
|
US $1.10 / g | 1g | 99.9% | 100 Tons min | Dideu Industries Group Limited | |
 |
2020-05-10 | Guanabenz
5051-62-7
|
US $0.00-0.00 / Kg | 1KG | 99.0% | 500 MT | Shaanxi Dideu Medichem Co. Ltd |
-
- GUANABENZ USP/EP/BP
5051-62-7
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
-
- Guanabenz
5051-62-7
- US $0.00-0.00 / Kg
- 99.0%
- Shaanxi Dideu Medichem Co. Ltd