IPI 145
- CAS No.
- 1201438-56-3
- Chemical Name:
- IPI 145
- Synonyms
- Duvelisib;IPI-14;CS-680;IPI 145;IPI-145;IPI-145, >=98%;IPI-145 INK197;IPI 145 USP/EP/BP;IPI-145 (INK-1197);DUVELISIB (IPI-145)
- CBNumber:
- CB32645143
- Molecular Formula:
- C22H17ClN6O
- Molecular Weight:
- 416.86
- MDL Number:
- MFCD15144635
- MOL File:
- 1201438-56-3.mol
- MSDS File:
- SDS
| Melting point | 205-206o C |
|---|---|
| Boiling point | 757.8±60.0 °C(Predicted) |
| Density | 1.474±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Soluble in DMSO (up to at least 25 mg/ml) |
| form | White solid. |
| pka | 10.05±0.10(Predicted) |
| color | White |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| FDA UNII | 610V23S0JI |
| NCI Dictionary of Cancer Terms | duvelisib |
| NCI Drug Dictionary | duvelisib |
| ATC code | L01EM04 |
IPI 145 price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 16800 | IPI-145 ≥98% | 1201438-56-3 | 500μg | $68 | 2024-03-01 | Buy |
| Cayman Chemical | 16800 | IPI-145 ≥98% | 1201438-56-3 | 1mg | $121 | 2024-03-01 | Buy |
| Cayman Chemical | 16800 | IPI-145 ≥98% | 1201438-56-3 | 5mg | $201 | 2024-03-01 | Buy |
| Cayman Chemical | 16800 | IPI-145 ≥98% | 1201438-56-3 | 10mg | $335 | 2024-03-01 | Buy |
| TRC | I739400 | IPI145 | 1201438-56-3 | 50mg | $225 | 2021-12-16 | Buy |
IPI 145 Chemical Properties,Uses,Production
Description
Duvelisib (1201438-56-3) is a potent and selective (IC50’s: PI3Kα = 1602nM, PI3Kβ = 85nM, PI3Kδ= 2.5nM, PI3Kγ = 27nM) dual PI3Kδ/γ inhibitor.1 It inhibits B and T cell proliferation, blocks neutrophil migration, and inhibits basophil activation. Duvelisib antagonizes B-cell receptor cross-linking activated pro-survival signals in primary chronic lymphocytic leukemia cells.2?Duvelisib also shows preclinical/clinical activity against other hematologic malignancies such as Non-Hodgkins lymphoma, T-cell lymphoma, and others.3,4?Useful clinical agent for the treatment of various blood cancers. Low-dose treatment of T-cell-inflamed tumor models of head and neck cancers with Duvelisib enhanced responses to PD-L1 blockade via suppression of myeloid-derived suppressor cells.5?Higher doses reversed the effect due to suppression of tumor-infiltrating T lymphocytes
Uses
IPI 145 is an 1,2-dihydroisoquinolin-1(2H)-one derivative and has been developed as a modulator of PI3 kinase.
Definition
ChEBI: 8-chloro-2-phenyl-3-[(1S)-1-(7H-purin-6-ylamino)ethyl]-1-isoquinolinone is a member of isoquinolines.
target
PI3K-δ
References
1) Winkler?et al.?(2013),?PI3K-δ and PI3K-γ Inhibition by IPI-145 Abrogates Immune Response and Suppresses Activity in Autoimmune and Inflammatory Disease Models;?Chem. Biol.?20?1309 2) Dong?et al.?(2014),?IPI-145 antagonizes intrinsic and extrinsic survival signals in chronic lymphocytic leukemia cells;?Blood?124?3583 3) Flinn?et al.?(2018),?Duvelisib, a novel dual inhibitor of PI3K-δ/γ, is clinically active in advances hematologic malignancies;?Blood?131?877 4) Faia?et al.?(2018),?The phosphoinositide-3 kinase (PI3K)-δ,γ inhibitor, duvelisib, shows preclinical synergy with multiple targeted therapies in hematologic malignancies;?PLoS One?13?e0200725 5) Davis?et al.?(2017),?Anti-PD-L1 Efficacy Can Be Enhanced by Inhibition of Myeloid-Derived Suppressor Cells with a Selective Inhibitor of PI3Kδ/γ;?Cancer Res.?77?2607
IPI 145 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29271 | 58 |
| AFINE CHEMICALS LIMITED | 0571-85134551 | info@afinechem.com | CHINA | 15377 | 58 |
| Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 | gksales1@gk-bio.com | China | 9339 | 58 |
Related articles
- A small-molecule inhibitor: IPI 145(Duvelisib)
- Duvelisib (IPI 145) is a small-molecule inhibitor of phosphatidylinositol-3 kinase that has been developed as an oral treatmen....
- Dec 27，2023
View Lastest Price from IPI 145 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-13 | Duvelisib (IPI-145; INK1197)
1201438-56-3
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2021-07-10 | Duvelisib (IPI-145; INK1197)
1201438-56-3
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2019-09-04 | IPI 145
1201438-56-3
|
US $5.00 / KG | 1KG | 99% | 1ton | Career Henan Chemical Co |
-
- Duvelisib (IPI-145; INK1197)
1201438-56-3
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- Duvelisib (IPI-145; INK1197)
1201438-56-3
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- IPI 145
1201438-56-3
- US $5.00 / KG
- 99%
- Career Henan Chemical Co