S1RA
- CAS No.
- 878141-96-9
- Chemical Name:
- S1RA
- Synonyms
- S1RA;E52862;CS-1020;S1RA, >=98%;S1RA(E-52862);S1RA, 878141-96-9;E-52862; E52862; E 52862;4-(2-{[5-Methyl-1-(naphthalen-2-yl)pyrazol-3-yl]oxy}ethyl)morpholine;4-(2-{[5-Methyl-1-(2-naphthyl)-1H-pyrazol-3-yl]oxy}ethyl)morpholi ne;4-[2-[[5-Methyl-1-(2-naphthalenyl)-1H-pyrazol-3-yl]oxy]ethyl]morpholine
- CBNumber:
- CB32667552
- Molecular Formula:
- C20H23N3O2
- Molecular Weight:
- 337.42
- MDL Number:
- MFCD25976945
- MOL File:
- 878141-96-9.mol
- MSDS File:
- SDS
| Boiling point | 528.1±50.0 °C(Predicted) |
|---|---|
| Density | 1.21±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | ≥10.35 mg/mL in DMSO; ≥12.23 mg/mL in EtOH; ≥56.1 mg/mL in H2O |
| form | solid |
| pka | 6.15±0.10(Predicted) |
| FDA UNII | ZW18DSD1H4 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
S1RA price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 16279 | S1RA ≥98% | 878141-96-9 | 500μg | $81 | 2024-03-01 | Buy |
| Cayman Chemical | 16279 | S1RA ≥98% | 878141-96-9 | 1mg | $152 | 2024-03-01 | Buy |
| Cayman Chemical | 16279 | S1RA ≥98% | 878141-96-9 | 5mg | $435 | 2024-03-01 | Buy |
| Cayman Chemical | 16279 | S1RA ≥98% | 878141-96-9 | 10mg | $711 | 2024-03-01 | Buy |
| Biorbyt Ltd | orb181123 | S1RA >98% | 878141-96-9 | 100mg | $765 | 2021-12-16 | Buy |
S1RA Chemical Properties,Uses,Production
Biological Activity
s1ra is a potent and selective antagonist of σ1 receptor (σ1r) with ki value of 17nm [1].s1ra is the first σ1 receptor antagonist with potent antinociceptive activities in various pain models. in the binding assay, s1ra shows good affinity to human σ1 receptor transfected in hek293 membranes with ki value of 17nm. the ki value for guinea pig brain membrane σ1 receptor is higher than 1μm. s1ra also shows no significant affinity to another 170 molecular targets including receptors, ion channels and enzymes [1, 2].in the mouse tests, s1ra exhibits potent analgesic effects on capsaicin-induced mechanical hypersensitivity and formalin-induced pain. besides that, s1ra inhibits both mechanical allodynia and thermal hypersensitivity with ed50 values of 23.4mg/kg and 18.8mg/kg in the partial sciatic nerve ligation model in mice [1].
References
[1] díaz j l, cuberes r, berrocal j, et al. synthesis and biological evaluation of the 1-arylpyrazole class of σ1 receptor antagonists: identification of 4-{2-[5-methyl-1-(naphthalen-2-yl)-1 h-pyrazol-3-yloxy] ethyl} morpholine (s1ra, e-52862). journal of medicinal chemistry, 2012, 55(19): 8211-8224.
[2] wunsch b. the σ1 receptor antagonist s1ra is a promising candidate for the treatment of neurogenic painj. journal of medicinal chemistry, 2012, 55(19): 8209-8210.
S1RA Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4647 | 58 |