ChemicalBook >> CAS DataBase List >>Propanenitrile, 3-[[4-[1-(2,2-difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyriMidinyl]aMino]-

Propanenitrile, 3-[[4-[1-(2,2-difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyriMidinyl]aMino]-

Propanenitrile, 3-[[4-[1-(2,2-difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyriMidinyl]aMino]- structure

CAS No.: 1111636-35-1

Chemical Name:: Propanenitrile, 3-[[4-[1-(2,2-difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyriMidinyl]aMino]-

Synonyms: CS-727;PF-04880594;PF-04880594/PF04880594;3-[[4-[1-(2,2-difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)pyrazol-4-yl]pyrimidin-2-yl]amino]propanenitrile;3-[[4-[1-(2,2-Difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyrimidinyl]amino]propanenitrile;Propanenitrile, 3-[[4-[1-(2,2-difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyriMidinyl]aMino]-;3-[[4-[1-(2,2-Difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyrimidinyl]amino]propanenitrile DISCONTINUED

CBNumber:: CB32667567

Molecular Formula:: C19H16F2N8

Molecular Weight:: 394.38

MDL Number:

MOL File:: 1111636-35-1.mol

MSDS File:: SDS

Last updated:2023-05-18 11:31:22

Request For Quotation

Propanenitrile, 3-[[4-[1-(2,2-difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyriMidinyl]aMino]- Properties

Density	1.48±0.1 g/cm3(Predicted)
storage temp.	room temp
solubility	Soluble in DMSO
pka	12.99±0.40(Predicted)
form	powder
color	white to beige

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P280-P304+P340+P312-P305+P351+P338-P337+P313

Propanenitrile, 3-[[4-[1-(2,2-difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyriMidinyl]aMino]- price More Price(7)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	PZ0294	PF-04880594 ≥98% (HPLC)	1111636-35-1	5MG	$115	2023-06-20	Buy
Sigma-Aldrich	PZ0294	PF-04880594 ≥98% (HPLC)	1111636-35-1	25MG	$361	2023-06-20	Buy
Medical Isotopes, Inc.	57031	3-[[4-[1-(2,2-Difluoroethyl)-3-(1H-pyrrolo[2,3-β]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyrimidinyl]amino]propanenitrile	1111636-35-1	5mg	$775	2021-12-16	Buy
Medical Isotopes, Inc.	57031	3-[[4-[1-(2,2-Difluoroethyl)-3-(1H-pyrrolo[2,3-β]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyrimidinyl]amino]propanenitrile	1111636-35-1	50mg	$3200	2021-12-16	Buy
DC Chemicals	DC8727	PF-04880594 >98%	1111636-35-1	250mg	$800	2021-12-16	Buy

Product number	Packaging	Price	Buy
PZ0294	5MG	$115	Buy
PZ0294	25MG	$361	Buy
57031	5mg	$775	Buy
57031	50mg	$3200	Buy
DC8727	250mg	$800	Buy

Propanenitrile, 3-[[4-[1-(2,2-difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyriMidinyl]aMino]- Chemical Properties,Uses,Production

Uses

3-[[4-[1-(2,2-Difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyrimidinyl]amino]propanenitrile is a pyrazole compound and a potential Raf inhibitors.

Biochem/physiol Actions

PF-04880594 is a potent and selective RAF inhibitor that inhibits both wild-type and mutant BRAF and CRAF. PF-04880594 potently inhibits tumor growth in BRAF-mutant melanoma xenograft models.

target

BRAFV599E

Propanenitrile, 3-[[4-[1-(2,2-difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyriMidinyl]aMino]- Preparation Products And Raw materials

Raw materials

Preparation Products

Propanenitrile, 3-[[4-[1-(2,2-difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyriMidinyl]aMino]- Suppliers

Global( 30)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Boyle Chemical Co., Ltd.		sales@boylechem.com	China	2923	55
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	96815	76
Jinan Trio PharmaTech Co., Ltd.	+86 (531) 88811783	sales@trio-pharmatech.com (International market)	China	1856	62
AdooQ Bioscience CHINA	025-58849295 18951903616;	info@adooq.cn	China	2989	60
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80
Jinan elephant international trading co., LTD		13006575422@163.com	China	6357	58
Shenzhen Polymeri Biochemical Technology Co., Ltd.	+86-400-002-6226 13028896684	sales@rrkchem.com	China	55717	58
Hangzhou Synstar pharmaceutical Technology CO.,Ltd	0571-85361029	synstar518@163.com	China	1991	58
DC Chemicals	021-58447131 13564518121	sales@dcchemicals.com	China	9414	58
Changzhou Chenhong Biotechnology Co., Ltd.	0519-85788828 13775037613	sales@chemrenpharm.com	China	3538	58

Supplier	Advantage
Shanghai Boyle Chemical Co., Ltd.	55
J & K SCIENTIFIC LTD.	76
Jinan Trio PharmaTech Co., Ltd.	62
AdooQ Bioscience CHINA	60
Sigma-Aldrich	80
Jinan elephant international trading co., LTD	58
Shenzhen Polymeri Biochemical Technology Co., Ltd.	58
Hangzhou Synstar pharmaceutical Technology CO.,Ltd	58
DC Chemicals	58
Changzhou Chenhong Biotechnology Co., Ltd.	58

Propanenitrile, 3-[[4-[1-(2,2-difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyriMidinyl]aMino]- PF-04880594 3-[[4-[1-(2,2-Difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyrimidinyl]amino]propanenitrile 3-[[4-[1-(2,2-difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)pyrazol-4-yl]pyrimidin-2-yl]amino]propanenitrile PF-04880594/PF04880594 CS-727 3-[[4-[1-(2,2-Difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyrimidinyl]amino]propanenitrile DISCONTINUED 1111636-35-1 C19H16F2N8