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Methyl [4,6-diaMino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidin-5-yl]carbaMate

Methyl [4,6-diaMino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidin-5-yl]carbaMate structure

CAS No.: 625115-52-8

Chemical Name:: Methyl [4,6-diaMino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidin-5-yl]carbaMate

Synonyms: Nelociguat;BAY 60-4552;Riociguat-4;Desmethyl Riociguat;N-Desmethyl Riociguat;methyl (4,6-diamino-2;Riociguat Impurity NK1;Riociguat EP Impurity A;Riociguat EP Impurity 4;Riociguat N-Desmethyl Impurity

CBNumber:: CB32668342

Molecular Formula:: C19H17FN8O2

Molecular Weight:: 408.39

MDL Number:: MFCD22741546

MOL File:: 625115-52-8.mol

MSDS File:: SDS

Last updated:2023-06-08 09:03:09

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Methyl [4,6-diaMino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidin-5-yl]carbaMate Properties

Melting point	>196oC (dec.)
Boiling point	533.3±50.0 °C(Predicted)
Density	1.58±0.1 g/cm3(Predicted)
storage temp.	-20°C Freezer
solubility	DMSO (Slightly, Heated), Methanol (Very Slightly, Heated)
pka	10.68±0.70(Predicted)
form	Solid
color	Light Brown
FDA UNII	M2A18LL56O

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302

Precautionary statements

P264-P270-P301+P312-P330-P501

NFPA 704

	0
2		0

Methyl [4,6-diaMino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidin-5-yl]carbaMate price More Price(17)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	D293285	N-DesmethylRiociguat	625115-52-8	50mg	$215	2021-12-16	Buy
TRC	D293285	N-DesmethylRiociguat	625115-52-8	250mg	$545	2021-12-16	Buy
Biorbyt Ltd	orb611824	Nelociguat	625115-52-8	100mg	$555.9	2021-12-16	Buy
Medical Isotopes, Inc.	69249	N-Desmethylriociguat	625115-52-8	10mg	$590	2021-12-16	Buy
ChemScene	CS-M2183	Nelociguat 99.73%	625115-52-8	200mg	$708	2021-12-16	Buy

Product number	Packaging	Price	Buy
D293285	50mg	$215	Buy
D293285	250mg	$545	Buy
orb611824	100mg	$555.9	Buy
69249	10mg	$590	Buy
CS-M2183	200mg	$708	Buy

Methyl [4,6-diaMino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidin-5-yl]carbaMate Chemical Properties,Uses,Production

Uses

N-Desmethyl-riociguat, is a complex that is part affiliated with potent oral stimulator for the treatment of pulmonary hypertension.

Definition

ChEBI: Nelociguat is a member of the class of pyrazolopyridines that is 1H-pyrazolo[3,4-b]pyridine which is substituted by a 2-fluorobenzyl and 4,6-diamino-5-[(methoxycarbonyl)amino]pyrimidin-2-yl groups at positions 1 and 3, respectively. It is an active metabolite of riociguat and a soluble guanylate cyclase stimulator developed by Bayer for the treatment of erectile dysfunction and heart failure. It has a role as a soluble guanylate cyclase activator, an antihypertensive agent, a drug metabolite and a vasodilator agent. It is a pyrazolopyridine, a member of monofluorobenzenes, a carbamate ester and an aminopyrimidine.

Methyl [4,6-diaMino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidin-5-yl]carbaMate Preparation Products And Raw materials

Raw materials

Preparation Products

Methyl [4,6-diaMino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidin-5-yl]carbaMate Suppliers

Global( 98)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
HaBo Hong Kong Co., Limited.	+86-25-18512596065	info@habotech.com	CHINA	933	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14336	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
Hefei Hirisun Pharmatech Co., Ltd	+8615056975894	shawn@hirisunpharm.com	CHINA	9923	58
Hangzhou Huarong Pharm Co., Ltd.	571-86758373 +8613588754946	sales@huarongpharm.com	CHINA	3149	58
sgtlifesciences pvt ltd	+8617013299288	dj@sgtlifesciences.com	China	12382	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Henan Aochuang Chemical Co.,Ltd.	+86-0371-63689365 +8618638391208	sales@aochuangchem.com	China	9425	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
HaBo Hong Kong Co., Limited.	58
Standardpharm Co. Ltd.	58
career henan chemical co	58
Hefei Hirisun Pharmatech Co., Ltd	58
Hangzhou Huarong Pharm Co., Ltd.	58
sgtlifesciences pvt ltd	58
InvivoChem	58
Henan Aochuang Chemical Co.,Ltd.	58
TargetMol Chemicals Inc.	58

View Lastest Price from Methyl [4,6-diaMino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidin-5-yl]carbaMate manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2022-09-08	Methyl [4,6-diaMino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidin-5-yl]carbaMate 625115-52-8	US $0.00-0.00 / kg	1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.
	2020-01-10	Name: Methyl [4,6-diaMino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidin-5-yl]carbaMate 625115-52-8	US $5.50 / KG	1KG	98%min	1kg,10kg,100kg	Career Henan Chemical Co

Methyl [4,6-diaMino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidin-5-yl]carbaMate
625115-52-8
US $0.00-0.00 / kg
98%
Henan Aochuang Chemical Co.,Ltd.

Name: Methyl [4,6-diaMino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidin-5-yl]carbaMate
625115-52-8
US $5.50 / KG
98%min
Career Henan Chemical Co

625115-52-8(Methyl [4,6-diaMino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidin-5-yl]carbaMate)Related Search:

Riociguat Impurtiy 6 Riociguat Impurity 18 Riociguat Impurity 16 2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)-N5,N5- dimethylpyrimidine-4,5,6-triamine 1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxaMide

Methyl 1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carbiMidate 6-amino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl) -7-methyl-7,9-dihydro-8H-purin-8-one isopropyl(4,6-diamino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b] pyridin-3-yl)pyrimidin-5-yl)(methyl)carbamate 6-amino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)- 7,9-dimethyl-7,9-dihydro-8H-purin-8-one BENZENEAZOMALONONITRILE

methyl (4,6-diamino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b] pyridin-3-yl)pyrimidin-5-yl)(ethyl)carbamate 1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carbonitrile 1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxylic acid 1-(3-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide 6-amino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)- 7,9-dihydro-8H-purin-8-one

Riociguat 4,6-PyriMidinediaMine, 2-[1-[(2-fluorophenyl)Methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-(phenylazo)- 2-[1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidine-4,5,6-triaMine

1of4

Methyl [4,6-diaMino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidin-5-yl]carbaMate Carbamic acid, N-[4,6-diamino-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinyl]-, methyl ester N-Desmethyl Riociguat BAY 60-4552 Nelociguat methyl N-[4,6-diamino-2-[1-[(2-fluorophenyl)methyl]pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl]carbamate Riociguat N-Desmethyl Impurity methyl (4,6-diamino-2 N-Desmethyl Riociguat/Methyl(4,6-diamino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-5-yl)carbamate Riociguat Impurity NK1 Name: Methyl [4,6-diaMino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidin-5-yl]carbaMate Riociguat-4 Riociguat Impurity 19/N-Desmethyl Riociguat/Methyl(4,6-diamino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-5-yl)carbamate Desmethyl Riociguat Desmethyl RiociguatQ: What is Desmethyl Riociguat Q: What is the CAS Number of Desmethyl Riociguat Q: What is the storage condition of Desmethyl Riociguat Q: What are the applications of Desmethyl Riociguat Carbamic acid,[4,6-diamino-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinyl]-, methyl ester inhibit,Inhibitor,Guanylate Cyclase,Nelociguat methyl [(4,6-diamino-2-{1-[(2-fluorophenyl)methyl]pyrazolo[3,4-b]pyridin-3-yl}pyrimidin-5-yl)amino]methanoate Riociguat EP Impurity A Riociguat EP Impurity A (N-Desmethyl Riociguat) Riociguat EP Impurity 4 625115-52-8 C19H17FN8O2