HIF-1alpha/2alpha Inhibitor
- CAS No.
- 329932-55-0
- Chemical Name:
- HIF-1alpha/2alpha Inhibitor
- Synonyms
- FM19G11;FM 19G11 NEW;FM19G11 >=98% (HPLC);HIF-1alpha/2alpha Inhibitor;HIF-1α/2α Inhibitor IV, FM19G11;2-Oxo-2-(p-tolyl)ethyl 3-(2,4-dinitrobenzamido)benzoate;[2-oxo-2-(p-tolyl)ethyl] 3-[(2,4-dinitrobenzoyl)amino]benzoate;3-[(2,4-Dinitrobenzoyl)amino]-benzoic acid 2-(4-methylphenyl)-2-oxoethyl ester;Benzoic acid, 3-[(2,4-dinitrobenzoyl)amino]-, 2-(4-methylphenyl)-2-oxoethyl ester
- CBNumber:
- CB32668403
- Molecular Formula:
- C23H17N3O8
- Molecular Weight:
- 463.4
- MDL Number:
- MFCD01174289
- MOL File:
- 329932-55-0.mol
- MSDS File:
- SDS
HIF-1alpha/2alpha Inhibitor price More Price(10)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | F8807 | FM19G11 ≥98% (HPLC) | 329932-55-0 | 5mg | $67.2 | 2024-03-01 | Buy |
Sigma-Aldrich | F8807 | FM19G11 ≥98% (HPLC) | 329932-55-0 | 25mg | $543 | 2024-03-01 | Buy |
Tocris | 6653 | FM19G11 ≥98%(HPLC) | 329932-55-0 | 25 | $463 | 2021-12-16 | Buy |
Tocris | 6653 | FM19G11 ≥98%(HPLC) | 329932-55-0 | 5 | $119 | 2021-12-16 | Buy |
Biosynth Carbosynth | BF168364 | FM 19G11 NEW | 329932-55-0 | 10mg | $125 | 2021-12-16 | Buy |
HIF-1alpha/2alpha Inhibitor Chemical Properties,Uses,Production
Uses
FM19G11 has been used as ahypoxia-inducible factor-1α (HIF- 1α):
- to study the effects ofFM19G11-loaded gold nanoparticles (NPs) on self-renewal and proliferation of ependymal stem progenitor cells (epSPCs) of mice
- to study its effects on the O6-methylguanine DNA-methyltransferase (MGMT) expression in glioblastoma (GBM) cells
- to study its effects on microphthalmia-associated transcription factor (MITF) expression in melanoma cell line
Definition
ChEBI: 3-[[(2,4-dinitrophenyl)-oxomethyl]amino]benzoic acid [2-(4-methylphenyl)-2-oxoethyl] ester is a member of benzamides.
Biochem/physiol Actions
FM19G11 is an inhibitor of Hypoxia Inducible Factors α (HIFα), reported to affect self-renewal and differentiation of stem cells. Hypoxia-inducible factors (HIFs) are transcription factors that respond to changes in available oxygen in the cellular environment. Among other functions (like angiogenesis), HIFα proteins affect the self-renewal and the differentiation processes of stem cells. FM19G11 inhibits the HIFα proteins that repress the target genes of the two α subunits, in various tumor cell lines as well as in adult and embryonic stem cell (ESC) models.
storage
Store at +4°C
HIF-1alpha/2alpha Inhibitor Preparation Products And Raw materials
Raw materials
Preparation Products
HIF-1alpha/2alpha Inhibitor Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2784 | 58 |
Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 3412 | 55 |
Shanghai Chaolan Chemical Technology Center | QQ:65489617 15618227136 | info@SuperLan-chem.com | China | 9365 | 58 |
Shanghai SuperLan Chemcial Technique Centre | 021-2022843681 15618226720 | chaolaichem@foxmail.com | China | 6870 | 58 |
Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |