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Canagliflozin heMihydrate

Canagliflozin heMihydrate
Canagliflozin heMihydrate structure
CAS No.
928672-86-0
Chemical Name:
Canagliflozin heMihydrate
Synonyms
Cageline;TA7284 hemihydrate;TA-7284 hemihydrate;Invokana hemihydrate;Canagliflozin hydrate;Cagliflozin heMihydrate;JNJ28431754 hemihydrate;JNJ 28431754 hemihydrate;JNJ-28431754 hemihydrate;Canagliflozin heMihydrate
CBNumber:
CB32677171
Molecular Formula:
C24H27FO6S
Formula Weight:
462.53
MOL File:
928672-86-0.mol

Canagliflozin heMihydrate Chemical Properties,Uses,Production

Description

Canagliflozin, an orally active and selective sodium–glucose cotransporter 2 (SGLT2) inhibitor, was co-developed by Mitsubishi Tanabe Pharma and Johnson & Johnson (J&J) for the treatment of type 2 diabetes mellitus (T2DM) and obesity. The drug was approved in March by the U.S. FDA and launched in April 2013 in the U.S. SGLT2 is involved in the glucose re-absorption pathway in the kidney, and its inhibition increases urinary glucose excretion, and reduces plasma glucose and HbA1c levels. In addition, canagliflozin is safe in combination with other commonly used antidiabetic agents and has a significant effect on body weight reduction. A recently published process patent from ScinoPharm Taiwan describes the synthesis of canagliflozin.

Chemical Synthesis

Synthesis of the aglycone region of canagliflozin was described in a separate patent by first condensing commercially available 5- bromo-2-methylbenzoyl chloride (14) and 2-(4-fluorophenyl)- thiophene (15) under Friedel–Crafts acylation conditions to give ketone 16 in 69% yield as a crystalline solid. Ketone 16 was then reduced with triethylsilyl hydride in the presence of BF3Et2O at low temperature to give aglycone bromide 17 in 70% yield. The precursor for the glycoside moiety, commercially available glycoside triol 18, was selectively treated with t-butyldiphenylsilyl chloride (TBDPSCl) in THF in the presence of imidazole to give the bis-silyl ether 19 in 81% yield. Next, a unique, stereospecific b-C-arylglucosidation was developed to secure the union of the aglyone- and glycoside-containing portions of canagliflozin. Bromide 17 was subjected to magnesium powder under standard Grignard conditions prior to treatment with AlCl3 in THF in situ. This resulting mixture was then exposed to a solution of compound 19 in PhOMe which had been pre-treated with n-BuLi, and the entire mixture was then warmed to 150 ℃ for 5 h to ultimately give the b-anomer 20 in 56% yield. Finally, removal of the silyl groups within 20 with tetrabutyl ammonium fluoride (TBAF) in THF delivered canagliflozin hydrate (III) in 73% yield.

Canagliflozin heMihydrate Preparation Products And Raw materials

Raw materials

Preparation Products


Canagliflozin heMihydrate Suppliers

Global( 174)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shanghai Rochi Pharmaceutical Co.,Ltd.
15000076078 0086-21-38751876
info@rochipharma.com CHINA 432 58
Anqing Chico Pharmaceutical Co., Ltd.
15380796838
chloewu@chicopharm.cn CHINA 341 58
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 21032 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 8882 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070
product@chemlin.com.cn CHINA 3013 60
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 E-mail:sales03@shyrchem.com
+86-21-34979012 sales03@shyrchem.com CHINA 739 60
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 26734 60
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29961 58
Shanghai Arbor Chemical Co., Ltd.
021-60451682
021-60451683 act@arborchemical.com CHINA 906 58

View Lastest Price from Canagliflozin heMihydrate manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-10-11 Canagliflozin heMihydrate
928672-86-0
US $10.00 / KG 100KG 99% 100 mt Hebei Guanlang Biotechnology Co., Ltd.
2021-08-31 Canagliflozin heMihydrate
928672-86-0
US $10.00 / KG 25Kg/Drum 99.99% 20 tons/month Wuhan Monad Medicine Tech Co.,LTD
2021-07-13 Canagliflozin hemihydrate
928672-86-0
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd

928672-86-0(Canagliflozin heMihydrate)Related Search:


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  • Canagliflozin hydrate (2:1)
  • Canagliflozin heMihydrate
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  • (1S)-1,5-Anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-D-glucitol hydrate (2:1)
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  • JNJ 28431754 hemihydrate
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  • JNJ-28431754 hemihydrate
  • JNJ28431754 HEMIHYDRATE; JNJ-28431754 HEMIHYDRATE; JNJ 28431754 HEMIHYDRATE; TA-7284 HEMIHYDRATE; TA7284 HEMIHYDRATE; INVOKANA HEMIHYDRATE
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  • 928672-86-0
  • 2C24H25FO5SH2O
  • C24H25FO5SH2O
  • C24H25FO5S12H2O
  • Canagliflozin
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