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Canagliflozin heMihydrate

CAS No.
928672-86-0
Chemical Name:
Canagliflozin heMihydrate
Synonyms
Canagliflozin hydrate;Cagliflozin heMihydrate;(2S,3R,4R,5S,6R)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol Hemihydrate;Cageline;NSC 36678;NSC 406879;TA7284 hemihydrate;TA-7284 hemihydrate;Invokana hemihydrate;Kaglie net semihydrate
CBNumber:
CB32677171
Molecular Formula:
2(C24H25FO5S).H2O
Molecular Weight:
462.53
MDL Number:
MFCD28975933
MOL File:
928672-86-0.mol
Modify Date:2022-11-11 13:01:00

Canagliflozin heMihydrate Properties

Melting point 94-96°C
storage temp. Hygroscopic, Refrigerator, under inert atmosphere
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
color White to Off-White
Stability Hygroscopic

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

Canagliflozin heMihydrate price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC C175258 CanagliflozinHemihydrate 928672-86-0 10mg $65 2021-12-16 Buy
TRC C175258 CanagliflozinHemihydrate 928672-86-0 50mg $140 2021-12-16 Buy
Biosynth Carbosynth FC103621 Canagliflozin hemihydrate 928672-86-0 10mg $44 2021-12-16 Buy
ChemScene CS-3205 Canagliflozinhemihydrate 99.95% 928672-86-0 5mg $50 2021-12-16 Buy
ChemScene CS-3205 Canagliflozinhemihydrate 99.95% 928672-86-0 10mg $70 2021-12-16 Buy
Product number Packaging Price Buy
C175258 10mg $65 Buy
C175258 50mg $140 Buy
FC103621 10mg $44 Buy
CS-3205 5mg $50 Buy
CS-3205 10mg $70 Buy

Canagliflozin heMihydrate Chemical Properties,Uses,Production

Description

Canagliflozin, an orally active and selective sodium–glucose cotransporter 2 (SGLT2) inhibitor, was co-developed by Mitsubishi Tanabe Pharma and Johnson & Johnson (J&J) for the treatment of type 2 diabetes mellitus (T2DM) and obesity. The drug was approved in March by the U.S. FDA and launched in April 2013 in the U.S. SGLT2 is involved in the glucose re-absorption pathway in the kidney, and its inhibition increases urinary glucose excretion, and reduces plasma glucose and HbA1c levels. In addition, canagliflozin is safe in combination with other commonly used antidiabetic agents and has a significant effect on body weight reduction. A recently published process patent from ScinoPharm Taiwan describes the synthesis of canagliflozin.

Uses

Canagliflozin Hemihydrate is a derivative of Canagliflozin (C175190), which is a sodium/glucose cotransporter 2 (SGLT2) inhibitor. Canagliflozin has been shown to dose dependently reduce calculated renal threshold for glucose excretion and increase urinary glucose excretion. Canagliflozin is a candidate for the treatment of type 2 diabetes and obesity.

Synthesis

Synthesis of the aglycone region of canagliflozin was described in a separate patent by first condensing commercially available 5- bromo-2-methylbenzoyl chloride (14) and 2-(4-fluorophenyl)- thiophene (15) under Friedel–Crafts acylation conditions to give ketone 16 in 69% yield as a crystalline solid. Ketone 16 was then reduced with triethylsilyl hydride in the presence of BF3Et2O at low temperature to give aglycone bromide 17 in 70% yield. The precursor for the glycoside moiety, commercially available glycoside triol 18, was selectively treated with t-butyldiphenylsilyl chloride (TBDPSCl) in THF in the presence of imidazole to give the bis-silyl ether 19 in 81% yield. Next, a unique, stereospecific b-C-arylglucosidation was developed to secure the union of the aglyone- and glycoside-containing portions of canagliflozin. Bromide 17 was subjected to magnesium powder under standard Grignard conditions prior to treatment with AlCl3 in THF in situ. This resulting mixture was then exposed to a solution of compound 19 in PhOMe which had been pre-treated with n-BuLi, and the entire mixture was then warmed to 150 ℃ for 5 h to ultimately give the b-anomer 20 in 56% yield. Finally, removal of the silyl groups within 20 with tetrabutyl ammonium fluoride (TBAF) in THF delivered canagliflozin hydrate (III) in 73% yield.

Canagliflozin heMihydrate Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 226)Suppliers
Supplier Tel Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-66670886 info@dakenchem.com China 17337 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21975 55
Hangzhou FandaChem Co.,Ltd.
+8615858145714 fandachem@gmail.com China 9361 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070 product@chemlin.com.cn CHINA 3012 60
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 E-mail:sales03@shyrchem.com sales03@shyrchem.com CHINA 738 60
ATK CHEMICAL COMPANY LIMITED
21-51619050 ivan@atkchemical.com China 31281 60
Anqing Chico Pharmaceutical Co., Ltd.
15380796838 chloewu@chicopharm.cn CHINA 341 58
career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29922 58
Shanghai Arbor Chemical Co., Ltd.
021-60451682 act@arborchemical.com CHINA 906 58
Biochempartner
0086-13720134139 candy@biochempartner.com CHINA 967 58

View Lastest Price from Canagliflozin heMihydrate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Canagliflozin heMihydrate pictures 2021-10-11 Canagliflozin heMihydrate
928672-86-0
US $10.00 / KG 100KG 99% 100 mt Hebei Guanlang Biotechnology Co., Ltd.
Canagliflozin heMihydrate pictures 2021-08-31 Canagliflozin heMihydrate
928672-86-0
US $10.00 / KG 25Kg/Drum 99.99% 20 tons/month Wuhan Monad Medicine Tech Co.,LTD
Canagliflozin hemihydrate pictures 2021-07-13 Canagliflozin hemihydrate
928672-86-0
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd

Canagliflozin heMihydrate Spectrum

Canagliflozin hydrate (2:1) Canagliflozin heMihydrate D-Glucitol, 1,5-anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]Methyl]-4-Methylphenyl]-, hydrate (2:1) Canagliflozin heMihydrates (1S)-1,5-Anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-D-glucitol hydrate (2:1) Cageline Invokana hemihydrate JNJ 28431754 hemihydrate JNJ28431754 hemihydrate JNJ-28431754 hemihydrate JNJ28431754 HEMIHYDRATE; JNJ-28431754 HEMIHYDRATE; JNJ 28431754 HEMIHYDRATE; TA-7284 HEMIHYDRATE; TA7284 HEMIHYDRATE; INVOKANA HEMIHYDRATE TA7284 hemihydrate TA-7284 hemihydrate bis((2S,3R,4R,5S,6R)-2-(3-{[5-(4-fluorophenyl)thio phen-2-yl]methyl}-4-methylphenyl)-6-(hydroxymet hyl)oxane-3,4,5-triol) hydrate Canagliflozin (API) Canagli ozin Hemi hydrate (1S)-1,5-anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-D-glucitol Hemihydrate Canagliflozin hemihydrate (JNJ 28431754) TIANFU-CHEM 928672-86-0 Canagliflozin heMihydrate NSC 36678 NSC 406879 Cagliflozin heMihydrate (2S,3R,4R,5S,6R)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol Hemihydrate Canagliflozin hydrate Kaglie net semihydrate 928672-86-0 2C24H25FO5SH2O C24H25FO5SH2O C24H25FO5S12H2O Canagliflozin API