Canagliflozin heMihydrate
- CAS No.
- 928672-86-0
- Chemical Name:
- Canagliflozin heMihydrate
- Synonyms
- Canagliflozin hydrate;Cagliflozin heMihydrate;(2S,3R,4R,5S,6R)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol Hemihydrate;Cageline;NSC 36678;NSC 406879;TA7284 hemihydrate;TA-7284 hemihydrate;Invokana hemihydrate;Kaglie net semihydrate
- CBNumber:
- CB32677171
- Molecular Formula:
- 2(C24H25FO5S).H2O
- Molecular Weight:
- 462.53
- MDL Number:
- MFCD28975933
- MOL File:
- 928672-86-0.mol
| Melting point | 94-96°C |
|---|---|
| storage temp. | Hygroscopic, Refrigerator, under inert atmosphere |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| color | White to Off-White |
| Stability | Hygroscopic |
| FDA UNII | 0SAC974Z85 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
Canagliflozin heMihydrate price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | C175258 | CanagliflozinHemihydrate | 928672-86-0 | 10mg | $65 | 2021-12-16 | Buy |
| TRC | C175258 | CanagliflozinHemihydrate | 928672-86-0 | 50mg | $140 | 2021-12-16 | Buy |
| ChemScene | CS-3205 | Canagliflozinhemihydrate 99.95% | 928672-86-0 | 100mg | $140 | 2021-12-16 | Buy |
| AK Scientific | 2301AH | Canagliflozinhemihydrate | 928672-86-0 | 10mg | $143 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC103621 | Canagliflozin hemihydrate | 928672-86-0 | 100mg | $200 | 2021-12-16 | Buy |
Canagliflozin heMihydrate Chemical Properties,Uses,Production
Description
Canagliflozin, an orally active and selective sodium–glucose cotransporter 2 (SGLT2) inhibitor, was co-developed by Mitsubishi Tanabe Pharma and Johnson & Johnson (J&J) for the treatment of type 2 diabetes mellitus (T2DM) and obesity. The drug was approved in March by the U.S. FDA and launched in April 2013 in the U.S. SGLT2 is involved in the glucose re-absorption pathway in the kidney, and its inhibition increases urinary glucose excretion, and reduces plasma glucose and HbA1c levels. In addition, canagliflozin is safe in combination with other commonly used antidiabetic agents and has a significant effect on body weight reduction. A recently published process patent from ScinoPharm Taiwan describes the synthesis of canagliflozin.
Uses
Canagliflozin Hemihydrate is a derivative of Canagliflozin (C175190), which is a sodium/glucose cotransporter 2 (SGLT2) inhibitor. Canagliflozin has been shown to dose dependently reduce calculated renal threshold for glucose excretion and increase urinary glucose excretion. Canagliflozin is a candidate for the treatment of type 2 diabetes and obesity.
Definition
ChEBI: Canagliflozin hydrate is a hydrate that is the hemihydrate form of canagliflozin. Used for treatment of type II diabetes via inhibition of sodium-glucose transport protein subtype 2. It has a role as a hypoglycemic agent and a sodium-glucose transport protein subtype 2 inhibitor. It contains a canagliflozin.
Synthesis
Synthesis of the aglycone region of canagliflozin was described in a separate patent by first condensing commercially available 5- bromo-2-methylbenzoyl chloride (14) and 2-(4-fluorophenyl)- thiophene (15) under Friedel¨CCrafts acylation conditions to give ketone 16 in 69% yield as a crystalline solid. Ketone 16 was then reduced with triethylsilyl hydride in the presence of BF3Et2O at low temperature to give aglycone bromide 17 in 70% yield. The precursor for the glycoside moiety, commercially available glycoside triol 18, was selectively treated with t-butyldiphenylsilyl chloride (TBDPSCl) in THF in the presence of imidazole to give the bis-silyl ether 19 in 81% yield. Next, a unique, stereospecific b-C-arylglucosidation was developed to secure the union of the aglyone- and glycoside-containing portions of canagliflozin. Bromide 17 was subjected to magnesium powder under standard Grignard conditions prior to treatment with AlCl3 in THF in situ. This resulting mixture was then exposed to a solution of compound 19 in PhOMe which had been pre-treated with n-BuLi, and the entire mixture was then warmed to 150 ?? for 5 h to ultimately give the b-anomer 20 in 56% yield. Finally, removal of the silyl groups within 20 with tetrabutyl ammonium fluoride (TBAF) in THF delivered canagliflozin hydrate (III) in 73% yield.
Canagliflozin heMihydrate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12456 | 58 |
| Ouhuang Engineering Materials (Hubei) Co., Ltd | +8617702722807 | admin@hbouhuang.com | China | 1696 | 58 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15928 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9348 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3012 | 60 |
| Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 - 03@ | sales03@shyrchem.com | CHINA | 738 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Anqing Chico Pharmaceutical Co., Ltd. | 15380796838 | chloewu@chicopharm.cn | CHINA | 341 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
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- Canagliflozin Hemihydrate, a groundbreaking compound in the fight against type 2 diabetes, represents a significant leap forwa....
- Apr 10，2024
- Canagliflozin hemihydrate: Application, Synthesis, Toxicity and safety
- Canagliflozin hemihydrate (Invokana) is a C-glucoside with a thiophene ring that is an orally available inhibitor of sodium-gl....
- Apr 3，2023
Related Qustion
- Q:Can Canagliflozin heMihydrate treat Glioblastoma(GBM) patients?
- A:Canaglifozin inhibits glioblastoma in vitro and the mechanism of action is related to the activation of AMPK.
- Nov 9，2023
View Lastest Price from Canagliflozin heMihydrate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-22 | Canagliflozin hemihydrate
928672-86-0
|
US $1.00 / KG | 1KG | 99.91% | 200000 | Ouhuang Engineering Materials (Hubei) Co., Ltd | |
 |
2024-01-04 | Canagliflozin hemihydrate
928672-86-0
|
US $0.00-0.00 / kg | 1kg | 99%，single impurity＜0.1 | 1 ton | Nanjing Fred Technology Co., Ltd | |
 |
2023-06-26 | Canagliflozin heMihydrate
928672-86-0
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd |
-
- Canagliflozin hemihydrate
928672-86-0
- US $1.00 / KG
- 99.91%
- Ouhuang Engineering Materials (Hubei) Co., Ltd
-
- Canagliflozin hemihydrate
928672-86-0
- US $0.00-0.00 / kg
- 99%，single impurity＜0.1
- Nanjing Fred Technology Co., Ltd
-
- Canagliflozin heMihydrate
928672-86-0
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd
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