GLPG0634
- CAS No.
- 1206101-20-3
- Chemical Name:
- GLPG0634
- Synonyms
- CS-1887;GLPG634 analog;Filgotinib analog;GLPG0634 analogue;GLPG0634 analog, Filgotinib analog;N-[5-[4-[(6-Cyano-3-pyridinyl)methoxy]phenyl][1,2,4]triazolo[1,5-a]pyridin-2-yl] cyclopropanecarboxa;N-[5-[4-[(6-cyano-3-pyridinyl)Methoxy]phenyl][1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxaMide;N-(5-(4-((6-cyanopyridin-3-yl)methoxy)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide;Cyclopropanecarboxamide, N-[5-[4-[(6-cyano-3-pyridinyl)methoxy]phenyl][1,2,4]triazolo[1,5-a]pyridin-2-yl]-;N-[5-[4-[(6-Cyano-3-pyridinyl)Methoxy]phenyl][1,2,4]triazolo[1,5-a]pyridin-2-yl] cyclopropanecarboxaMide (GLPG0634)
- CBNumber:
- CB32681970
- Molecular Formula:
- C23H18N6O2
- Molecular Weight:
- 410.43
- MDL Number:
- MOL File:
- 1206101-20-3.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
GLPG0634 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | C982190 | N-[5-[4-[(6-Cyano-3-pyridinyl)methoxy]phenyl][1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide | 1206101-20-3 | 2.5mg | $185 | 2021-12-16 | Buy |
| ApexBio Technology | B6116 | GLPG0634analogue | 1206101-20-3 | 5mg | $228 | 2021-12-16 | Buy |
| ChemScene | CS-3293 | GLPG0634analog 98.58% | 1206101-20-3 | 10mg | $280 | 2021-12-16 | Buy |
| ChemScene | CS-3293 | GLPG0634analog 98.58% | 1206101-20-3 | 5mg | $100 | 2021-12-16 | Buy |
| ChemScene | CS-3293 | GLPG0634analog 98.58% | 1206101-20-3 | 50mg | $600 | 2021-12-16 | Buy |
GLPG0634 Chemical Properties,Uses,Production
Uses
N-[5-[4-[(6-Cyano-3-pyridinyl)methoxy]phenyl][1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide, is an orally-available, selective inhibitor of JAK1 (Janus kinase 1), used for the treatment of rheumatoid arthritis and potentially other inflammatory diseases.
Biological Activity
glpg0634 is a potent and selective inhibitor of jak1 with ic50 values of 10, 28, 810 and 116 nm for jak1, jak2, jak3 and tyk2, respectively [1].janus kinase 1 (jak1) is a member of the jak family and is a non-receptor tyrosine kinase. jaks play an important role in the immune system. jak1 is a potential target for the treatment of immune-inflammatory diseases [1].glpg0634 is a potent and selective jak1 inhibitor. glpg0634 inhibited jak1, jak2, jak3 and tyk2 with ic50 values of 10, 28, 810 and 116 nm, respectively. in cd4+ t cells, glpg0634 significantly reduced il-6-induced stat1 phosphorylation with ic50 value of 629 nm, which suggested the inhibition of jak1. in cd33+ t cells, glpg0634 reduced gm-csf-induced stat5 phosphorylation with ic50 value of 17.5 μm, suggesting the inhibition of jak2. glpg0634 inhibited the differentiation of th1 and th2 cells mediated by il-4 and il-12, respectively. also, glpg0634 inhibited th17 differentiation induced by tgf-β, il-23, il-6 and il-1β [1].in rats, glpg0634 significantly reduced the mrna levels of mx2, which were modulated by ifn-α-jak1/tyk2 signaling. in collagen-induced arthritis (cia) rat model, glpg0634 significantly reduced the infiltration of inflammatory cells and reduced the levels of il-6, ip-10, xcl1 and mcp-1 [1].
target
JAK1
References
[1]. van rompaey l, galien r, van der aar em, et al. preclinical characterization of glpg0634, a selective inhibitor of jak1, for the treatment of inflammatory diseases. j immunol, 2013, 191(7): 3568-3577.
GLPG0634 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9641 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
