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EMPA

EMPA Structure
EMPA structure
CAS No.
680590-49-2
Chemical Name:
EMPA
Synonyms
EMPA, CID 9981404;Hypocretin Receptor,EMPA,Orexin Receptor (OX Receptor),HCRT Receptor,inhibit,Inhibitor;N-ETHYL-2-[(6-METHOXYPYRIDIN-3-YL)-(2-METHYLPHENYL)SULFONYLAMINO]-N-(PYRIDIN-3-YLMETHYL)ACETAMIDE;N-Ethyl-2-[(6-methoxy-3-pyridinyl)[(2-methylphenyl)sulfonyl]amino]-N-(3-pyridinylmethyl)-acetamide;Acetamide, N-ethyl-2-[(6-methoxy-3-pyridinyl)[(2-methylphenyl)sulfonyl]amino]-N-(3-pyridinylmethyl)-
CBNumber:
CB32695845
Molecular Formula:
C23H26N4O4S
Molecular Weight:
454.54
MDL Number:
MOL File:
680590-49-2.mol
Last updated:2023-09-04 16:42:00
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EMPA Properties

Boiling point 660.7±65.0 °C(Predicted)
Density 1.280±0.06 g/cm3(Predicted)
storage temp. -20°C
solubility Soluble to 100 mM in DMSO and to 100 mM in ethanol
form Powder
pka 4.77±0.10(Predicted)
color white to light brown
FDA UNII VT87V86D7W

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P330-P501
Hazard Codes  Xn
Risk Statements  22
WGK Germany  3
NFPA 704
0
2 0

EMPA price More Price(12)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML0864 EMPA ≥98% (HPLC) 680590-49-2 5mg $132 2024-03-01 Buy
Sigma-Aldrich SML0864 EMPA ≥98% (HPLC) 680590-49-2 25mg $430 2024-03-01 Buy
Cayman Chemical 29446 EMPA 680590-49-2 5mg $117 2024-03-01 Buy
Cayman Chemical 29446 EMPA 680590-49-2 10mg $186 2024-03-01 Buy
TRC E521550 EMPA 680590-49-2 100mg $1210 2021-12-16 Buy
Product number Packaging Price Buy
SML0864 5mg $132 Buy
SML0864 25mg $430 Buy
29446 5mg $117 Buy
29446 10mg $186 Buy
E521550 100mg $1210 Buy

EMPA Chemical Properties,Uses,Production

Description

EMPA is an orexin 2 receptor (OX2R) antagonist (Ki = 1.1 nM). It is selective for OX2R over OX1R (Ki = 900 nM). EMPA inhibits orexin-A- and orexin-B-induced calcium mobilization (IC50s = 8.8 and 7.9 nM, respectively) and increases orexin-A- and orexin-B-induced inositol phosphate accumulation (EC50s = 1.1 and 2.4 nM, respectively) in CHO(dHFr-) cells expressing recombinant human OX2R. It reduces spontaneous locomotor activity and orexin-B-induced hyperlocomotion in mice when administered at doses ranging between 10 and 300 mg/kg.

Uses

EMPA is a novel high-affinity, selective antagonist for the OX2 receptor.

storage

Store at -20°C

EMPA Preparation Products And Raw materials

Raw materials

Preparation Products

EMPA Suppliers

Global( 40)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32480 60
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
Aladdin Scientific 		+1-833-552-7181 sales@aladdinsci.com United States 57511 58
J & K SCIENTIFIC LTD. 010-82848833 400-666-7788 jkinfo@jkchemical.com China 96815 76
Shanghai TaoSu Biochemical Technology Co., Ltd. 021-33632979 info@tsbiochem.com China 8073 58
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 sales-cpd@caerulumpharma.com China 3421 58
HangZhou YuHao Chemical Technology Co., Ltd. 0571-82693216 info@yuhaochemical.com China 2031 58
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4121 55
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9709 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
TargetMol Chemicals Inc. 		58
InvivoChem 		58
Aladdin Scientific 		58
J & K SCIENTIFIC LTD. 76
Shanghai TaoSu Biochemical Technology Co., Ltd. 58
ShangHai Caerulum Pharma Discovery Co., Ltd. 58
HangZhou YuHao Chemical Technology Co., Ltd. 58
Shanghai Lollane Biological Technology Co.,Ltd. 55
Shanghai EFE Biological Technology Co., Ltd. 58

EMPA Spectrum

EMPA(680590-49-2)1HNMR

680590-49-2(EMPA)Related Search:

Deionized water N,N'-Ethylenebis(stearamide) (2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride
N-Ethyl-2-[(6-methoxy-3-pyridinyl)[(2-methylphenyl)sulfonyl]amino]-N-(3-pyridinylmethyl)-acetamide N-ETHYL-2-[(6-METHOXYPYRIDIN-3-YL)-(2-METHYLPHENYL)SULFONYLAMINO]-N-(PYRIDIN-3-YLMETHYL)ACETAMIDE EMPA, CID 9981404 Acetamide, N-ethyl-2-[(6-methoxy-3-pyridinyl)[(2-methylphenyl)sulfonyl]amino]-N-(3-pyridinylmethyl)- Hypocretin Receptor,EMPA,Orexin Receptor (OX Receptor),HCRT Receptor,inhibit,Inhibitor 680590-49-2 Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds