API-2
- CAS No.
- 35943-35-2
- Chemical Name:
- API-2
- Synonyms
- TCN;IAP1;MIHC;MYHL;BBMI;API-2;BIRC3;RNF49;MYO1A;DFNA48
- CBNumber:
- CB3270000
- Molecular Formula:
- C13H16N6O4
- Molecular Weight:
- 320.3
- MDL Number:
- MFCD00932413
- MOL File:
- 35943-35-2.mol
- MSDS File:
- SDS
Melting point | 207 °C (decomp) |
---|---|
Boiling point | 459.21°C (rough estimate) |
Density | 1.2633 (rough estimate) |
refractive index | 1.7000 (estimate) |
storage temp. | Store at RT |
solubility | DMSO: >10mg/mL |
form | powder |
pka | 12.35±0.70(Predicted) |
color | tan |
InChIKey | HOGVTUZUJGHKPL-HTVVRFAVSA-N |
FDA UNII | 2421HMY9N6 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H317-H319 |
Precautionary statements | P280-P305+P351+P338 |
WGK Germany | 3 |
RTECS | RY8455000 |
API-2 price More Price(38)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | T3830 | Triciribine hydrate ≥97% (HPLC) | 35943-35-2 | 5mg | $274 | 2024-03-01 | Buy |
Sigma-Aldrich | 124038 | InSolution? Akt Inhibitor V, Triciribine | 35943-35-2 | 2mg | $345 | 2024-03-01 | Buy |
Sigma-Aldrich | SAB1303874 | ANTI-MYO1A (CENTER S291) antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution | 35943-35-2 | 400μL | $461 | 2023-01-07 | Buy |
Cayman Chemical | 10010237 | Triciribine ≥98% | 35943-35-2 | 1mg | $47 | 2024-03-01 | Buy |
Cayman Chemical | 10010237 | Triciribine ≥98% | 35943-35-2 | 5mg | $107 | 2024-03-01 | Buy |
API-2 Chemical Properties,Uses,Production
Chemical Properties
Off-White Solid
Uses
Triciribine is an antitumor tricyclic nucleoside. Triciribine acts as a potent, small-molecule inhibitor of AKT phosphorylation in subjects with solid tumors contining activated AKT. Triciribine is al so a selective inhibitor of HIV-1 and HIV-2, including strains known to be resistant to AZT or TIBO.
Uses
Triciribine hydrate has been used to study the effect of diethyldithiocarbamate (DDC) on matrix metalloproteinase-1 (MMP-1) in hepatic stellate cells1. It has also been used to analyze ADAM 10 activation by (-)-epigallocatechin-3-gallate (EGCG) in N2a cells overexpressing Swedish mutant APP (SweAPP N2a cells)2.
Uses
Triciribine is an antitumor tricyclic nucleoside. Triciribine acts as a potent, small-molecule inhibitor of AKT phosphorylation in subjects with solid tumors contining activated AKT. Triciribine is also a selective inhibitor of HIV-1 and HIV-2, including strains known to be resistant to AZT or TIBO.
Definition
ChEBI: Triciribine is a nucleoside analogue in which the nucleobase portion is a 1,4,5,6,8-pentaazaacenaphthylene ring system substituted with an amino group at position 3, and a methyl group at position 5 and is bound to the beta-D-ribofuranosyl moiety by an N(1)-glycosidic linkage. It has a role as an EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor.
Biological Activity
Selective inhibitor of Akt (protein kinase B) signaling; displays minimal inhibition of PKC, PKA, SGK and p38 pathways. Inhibits phosphorylation and activation of downstream targets of Akt including Bad, GSK-3 β and AFX. In vitro, induces apoptosis and growth arrest preferentially in human cancer cells with elevated levels of Akt. In mice, potently and selectively inhibits growth of Akt-overexpressing tumors. Inhibits DNA synthesis and displays antiviral activity against HIV-1 and -2.
Biochem/physiol Actions
Triciribine is a highly selective Akt/PKB inhibitor, that selectively inhibits the cellular phosphorylation/activation of Akt1/2/3.
storage
Store at RT
API-2 Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Wuhan Haorong Biotechnology Co.,ltd | +8618565342920 | sales@chembj.net | China | 268 | 58 |
career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 12321 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29831 | 58 |
Wuhan Nutra Biotechnology Co.,Ltd | +8617786394783 | nutrabiotech@outlook.com | China | 300 | 58 |
Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | CHINA | 52867 | 58 |
View Lastest Price from API-2 manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-03-26 | API-2 / TRICIRIBINE
35943-35-2
|
US $0.00-0.00 / KG | 1KG | 99% | 5000 | Wuhan Haorong Biotechnology Co.,Ltd | ||
2023-10-10 | API-2
35943-35-2
|
US $1.00 / g | 1g | 99% | 100kg | Wuhan Cell Pharmaceutical Co., Ltd | ||
2021-10-08 | Triciribine hydrate;TCN
35943-35-2
|
US $0.00-0.00 / g | 10g | 98%+ | 100kgs | Wuhan Nutra Biotechnology Co.,Ltd |
- API-2 / TRICIRIBINE
35943-35-2
- US $0.00-0.00 / KG
- 99%
- Wuhan Haorong Biotechnology Co.,Ltd
- API-2
35943-35-2
- US $1.00 / g
- 99%
- Wuhan Cell Pharmaceutical Co., Ltd
- Triciribine hydrate;TCN
35943-35-2
- US $0.00-0.00 / g
- 98%+
- Wuhan Nutra Biotechnology Co.,Ltd
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