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API-2

CAS No.
35943-35-2
Chemical Name:
API-2
Synonyms
TCN;IAP1;MIHC;MYHL;BBMI;API-2;BIRC3;RNF49;MYO1A;DFNA48
CBNumber:
CB3270000
Molecular Formula:
C13H16N6O4
Molecular Weight:
320.3
MDL Number:
MFCD00932413
MOL File:
35943-35-2.mol
MSDS File:
SDS
Last updated:2023-08-07 22:27:18

API-2 Properties

Melting point 207 °C (decomp)
Boiling point 459.21°C (rough estimate)
Density 1.2633 (rough estimate)
refractive index 1.7000 (estimate)
storage temp. Store at RT
solubility DMSO: >10mg/mL
form powder
pka 12.35±0.70(Predicted)
color tan
InChIKey HOGVTUZUJGHKPL-HTVVRFAVSA-N
FDA UNII 2421HMY9N6

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H317-H319
Precautionary statements  P280-P305+P351+P338
WGK Germany  3
RTECS  RY8455000

API-2 price More Price(38)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich T3830 Triciribine hydrate ≥97% (HPLC) 35943-35-2 5mg $274 2024-03-01 Buy
Sigma-Aldrich 124038 InSolution? Akt Inhibitor V, Triciribine 35943-35-2 2mg $345 2024-03-01 Buy
Sigma-Aldrich SAB1303874 ANTI-MYO1A (CENTER S291) antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution 35943-35-2 400μL $461 2023-01-07 Buy
Cayman Chemical 10010237 Triciribine ≥98% 35943-35-2 1mg $47 2024-03-01 Buy
Cayman Chemical 10010237 Triciribine ≥98% 35943-35-2 5mg $107 2024-03-01 Buy
Product number Packaging Price Buy
T3830 5mg $274 Buy
124038 2mg $345 Buy
SAB1303874 400μL $461 Buy
10010237 1mg $47 Buy
10010237 5mg $107 Buy

API-2 Chemical Properties,Uses,Production

Chemical Properties

Off-White Solid

Uses

Triciribine is an antitumor tricyclic nucleoside. Triciribine acts as a potent, small-molecule inhibitor of AKT phosphorylation in subjects with solid tumors contining activated AKT. Triciribine is al so a selective inhibitor of HIV-1 and HIV-2, including strains known to be resistant to AZT or TIBO.

Uses

Triciribine hydrate has been used to study the effect of diethyldithiocarbamate (DDC) on matrix metalloproteinase-1 (MMP-1) in hepatic stellate cells1. It has also been used to analyze ADAM 10 activation by (-)-epigallocatechin-3-gallate (EGCG) in N2a cells overexpressing Swedish mutant APP (SweAPP N2a cells)2.

Uses

Triciribine is an antitumor tricyclic nucleoside. Triciribine acts as a potent, small-molecule inhibitor of AKT phosphorylation in subjects with solid tumors contining activated AKT. Triciribine is also a selective inhibitor of HIV-1 and HIV-2, including strains known to be resistant to AZT or TIBO.

Definition

ChEBI: Triciribine is a nucleoside analogue in which the nucleobase portion is a 1,4,5,6,8-pentaazaacenaphthylene ring system substituted with an amino group at position 3, and a methyl group at position 5 and is bound to the beta-D-ribofuranosyl moiety by an N(1)-glycosidic linkage. It has a role as an EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor.

Biological Activity

Selective inhibitor of Akt (protein kinase B) signaling; displays minimal inhibition of PKC, PKA, SGK and p38 pathways. Inhibits phosphorylation and activation of downstream targets of Akt including Bad, GSK-3 β and AFX. In vitro, induces apoptosis and growth arrest preferentially in human cancer cells with elevated levels of Akt. In mice, potently and selectively inhibits growth of Akt-overexpressing tumors. Inhibits DNA synthesis and displays antiviral activity against HIV-1 and -2.

Biochem/physiol Actions

Triciribine is a highly selective Akt/PKB inhibitor, that selectively inhibits the cellular phosphorylation/activation of Akt1/2/3.

storage

Store at RT

API-2 Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 150)Suppliers
Supplier Tel Email Country ProdList Advantage
Wuhan Haorong Biotechnology Co.,ltd
+8618565342920 sales@chembj.net China 268 58
career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29914 58
Biochempartner
0086-13720134139 candy@biochempartner.com CHINA 967 58
Hubei Jusheng Technology Co.,Ltd.
18871490254 linda@hubeijusheng.com CHINA 28180 58
BOC Sciences
+1-631-485-4226 inquiry@bocsci.com United States 19553 58
Chongqing Chemdad Co., Ltd
+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
Zhengzhou Alfa Chemical Co.,Ltd
+8618530059196 sale04@alfachem.cn China 12321 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250 1026@dideu.com China 29831 58
Wuhan Nutra Biotechnology Co.,Ltd
+8617786394783 nutrabiotech@outlook.com China 300 58
Dayang Chem (Hangzhou) Co.,Ltd.
571-88938639 +8617705817739 info@dycnchem.com CHINA 52867 58

View Lastest Price from API-2 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
API-2 / TRICIRIBINE pictures 2024-03-26 API-2 / TRICIRIBINE
35943-35-2
US $0.00-0.00 / KG 1KG 99% 5000 Wuhan Haorong Biotechnology Co.,Ltd
API-2 pictures 2023-10-10 API-2
35943-35-2
US $1.00 / g 1g 99% 100kg Wuhan Cell Pharmaceutical Co., Ltd
Triciribine hydrate;TCN pictures 2021-10-08 Triciribine hydrate;TCN
35943-35-2
US $0.00-0.00 / g 10g 98%+ 100kgs Wuhan Nutra Biotechnology Co.,Ltd
  • API-2 pictures
  • API-2
    35943-35-2
  • US $1.00 / g
  • 99%
  • Wuhan Cell Pharmaceutical Co., Ltd

API-2 Spectrum

API-2 6-AMINO-4-METHYL-8-(BETA-D-RIBOFURANOSYL)-4H,8H-PYRROLO[4,3,2-DE]PYRIMIDO[4,5-C]PYRIDAZINE AKT/PKB SIGNALING INHIBITOR-2 AKT INHIBITOR V 1,5-DIHYDRO-5-METHYL-1-BETA-D-RIBOFURANOSYL-1,4,5,6,8-PENTAAZAACENAPHTHYLEN-3-AMINE 1,4,5,6,8-pentaazaacenaphthylen-3-amine,1,5-dihydro-5-methyl-1-beta-d-ribofura API-2 (Tricirbine) TRICIRIBINE NSC 154020 TCN 1,5-Dihydro-5-methyl-1-β-D-ribofuranosyl-1,4,5,6,8-pentaazaacenaphthylen-3-amine (1,4,5,6,8-Pentaazaacenaphthylen-3-aMine,1,5-dihydro-5-Methyl-1-b-D-ribofuranosyl-) 6-AMino-4-Methyl-8-(β-D-ribofuranosyl)-4H,8H-pyrrolo[4,3,2-de]pyriMido[4,5-c]pyridazine (2R,3R,4S,5R)-2-(3-aMino-5-Methyl-1,4,5,6,8-pentaazaacenaphthylen-1(5H)-yl)-5-(hydroxyMethyl)tetrahydrofuran-3,4-diol VD-0002 1,5-Dihydro-5-methyl-1-beta-D-ribofuranosyl-1,4,5,6,8-pentaazaacenaphthylen-3-amine Triciribine Triciribine 1,5-Dihydro-5-methyl-1-beta-D-ribofuranosyl-1,4,5,6,8-pentaazaacenaphthylen-3-amine Inhibitor V (1R,2S,3R,5R)-3-(3-Amino-5-methyl-1,4,5,6,8-pentaazaacenaphthylen-1(5H)-yl)-5-(hydroxymethyl)c InSolution? Akt Inhibitor V, Triciribine Triciribine hydrate ANTI-CIAP2 (BIRC3)(N-TERMINAL) antibody produced in rabbit BIRC3 IAP1 MIHC RNF49 ANTI-MYO1A (CENTER S291) antibody produced in rabbit Brush border myosin I MYHL Myosin-Ia Anti-MYO1A antibody produced in rabbit BBMI DFNA48 MYO1A Anti-Dfna48 Anti-Myhl Anti-Myosin ia Triciribine, >=98% 1,4,5,6,8-pentaazaacenaphthylene,3-amino-1,5-dihydro-5-methyl-1-beta-d-ribof 3-amine 3-amino-1,5-dihydro-5-methyl-1-beta-d-ribofuranosyl-1,4,5,6,8-pentaazaacenap 4,5,6,8-pentaazaacenaphthylen-5-dihydro-5-methyl-1-beta-d-ribofuranosyl-1 hthylene nosyl- pentaazacentopthylene uranosyl- TRICYCLIC NUCLEOSIDE CS-542 API-2; NSC 154020; TCN CS-690 Triciribine, NSC 154020, TCN InSolution Akt Inhibitor V, Triciribine - CAS 35943-35-2 - Calbiochem Triciribine (NSC-154020) Triciribine, 98%, a DNA synthesis inhibitor Tricirbine 1,4,5,6,8-Pentaazaacenaphthylen-3-amine, 1,5-dihydro-5-methyl-1-β-D-ribofuranosyl- API-2 USP/EP/BP Triciribine 13CD3