EveroliMus-d4
- CAS No.
- 1338452-54-2
- Chemical Name:
- EveroliMus-d4
- Synonyms
- Everolimus-d4;EveroliMus-d4 (~90%);EVEROLIMUS (2-HYDROXYETHYL-D4, 98%);Everolimus-d4 (Everolimus Impurity);Everolimus Impurity 24(Everolimus-d4);Everolimus D4Q: What is Everolimus D4 Q: What is the CAS Number of Everolimus D4 Q: What is the storage condition of Everolimus D4 Q: What are the applications of Everolimus D4
- CBNumber:
- CB32714520
- Molecular Formula:
- C53H79D4NO14
- Molecular Weight:
- 962.249067112
- MDL Number:
- MOL File:
- 1338452-54-2.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H372 |
| Precautionary statements | P260-P264-P270-P314-P501 |
EveroliMus-d4 price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | E-070 | Everolimus-D4 solution 100?μg/mLinacetonitrile,ampuleof1?mL,certifiedreferencematerial,Cerilli | 1338452-54-2 | 1mL | $586 | 2024-03-01 | Buy |
| Cayman Chemical | 22559 | Everolimus-d4 ≥99% deuterated forms (d1-d4); ≤1% d0 | 1338452-54-2 | 500μg | $145 | 2024-03-01 | Buy |
| Cayman Chemical | 22559 | Everolimus-d4 ≥99% deuterated forms (d1-d4); ≤1% d0 | 1338452-54-2 | 1mg | $262 | 2024-03-01 | Buy |
| TRC | E945402 | Everolimus-d4(~90%) | 1338452-54-2 | 10mg | $1695 | 2021-12-16 | Buy |
| IsoSciences | 14001 | Everolimus-[d4] ≥98% | 1338452-54-2 | 1mg | $190 | 2021-12-16 | Buy |
EveroliMus-d4 Chemical Properties,Uses,Production
Description
Everolimus-d4 is intended for use as an internal standard for the quantification of everolimus by GC- or LC-MS. Everolimus is a hydroxyethyl ether form of rapamycin that inhibits mTOR signaling through both mTORC1 and mTORC2 when added to cells at 20 nM. It is orally available and shows improved pharmacokinetics and pharmacodynamics over rapamycin. Through its inhibition of mTOR, everolimus inhibits cell proliferation, metabolism, and angiogenesis in certain types of cancer. It also acts as an immunosuppressive agent in the context of organ transplantation.
Uses
Macrolide immunosuppressant; derivative of Rapamycin. Inhibits cytokine-mediated lymphocyte proliferation.
General Description
A stable-labeled internal standard for the immunosuppressant Everolimus, marketed as Zortress? and Certican for use in organ transplantation and Afinitor? for treatment of kidney and pancreatic cancers. Clinical laboratories quantitate everolimus levels in patient whole blood samples using LC-MS/MS. While many everolimus LC-MS/MS methods use 32-desmethoxyrapamycin or ascomycin as an internal standard, higher levels of variability / lower levels of reproducibility may occur in the analysis along with the potential for interferences. Use of a stable-labeled analog of everolimus is the best choice to minimize variability or mitigate any potential interference in LC-MS/MS analysis.
EveroliMus-d4 Preparation Products And Raw materials
Raw materials
Preparation Products
EveroliMus-d4 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14336 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32344 | 50 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 18521732826; | market@aladdin-e.com | China | 25015 | 65 |
| Cato Research Chemicals Inc. | 020-81960175 | min.he@cato-chem.com | China | 1958 | 55 |
| Artis Biotech Co. Ltd. | 19138486554 18582380095 | sales@artisbio.com | China | 3066 | 58 |
| Nanjing Haolv Biotechnology Co.,Ltd | 025-84622273 02584622273; | kexin.zhou@haolvbiotech.com | China | 3021 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 | sales@rrkchem.com | China | 55717 | 58 |
| Hefei Molake Biotechnology Co., Ltd. | 0551-66336380 18956014586 | 983438788@qq.com | China | 2076 | 58 |
| Guangzhou Dreampharm Biotechnology Co., Ltd. | 17825480238 | 3008233717@qq.com | China | 9844 | 12 |
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