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ML277

ML277 Structure
ML277 structure
CAS No.
1401242-74-7
Chemical Name:
ML277
Synonyms
ML277;CID-53347902;ML277;ML 277; ML-277;VU0458298-2, VU0458298-3;ML-277;ML 277;CID-53347902;CID53347902;CID 53347902;(R)-N-(4-(4-Methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide;(2R)-N-[4-(4-Methoxyphenyl)-2-thiazolyl]-1-[(4-methylphenyl)sulfonyl]-2-piperidinecarboxamide;N-[4-(4-methoxy-phenyl)-thiazol-2-]-1-[1-(4-Methylbenzenesulfonyl) pip- eridine -2-] formamide;(2R)-N-[4-(4-Methoxyphenyl)-1,3-thiazol-2-yl]-1-(4-methylphenyl)sulfonylpiperidine-2-carboxamide;2-Piperidinecarboxamide, N-[4-(4-methoxyphenyl)-2-thiazolyl]-1-[(4-methylphenyl)sulfonyl]-, (2R)-
CBNumber:
CB32715653
Molecular Formula:
C23H25N3O4S2
Molecular Weight:
471.59
MDL Number:
MFCD28133374
MOL File:
1401242-74-7.mol
MSDS File:
SDS
Last updated:2023-09-20 16:43:00
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ML277 Properties

Density 1.341±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: 5 mg/ml
pka 8.37±0.70(Predicted)
form powder
color white to beige

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H319
Precautionary statements  P264-P270-P280-P301+P312-P305+P351+P338-P337+P313
Hazard Codes  Xn
Risk Statements  22-36
Safety Statements  26
WGK Germany  3

ML277 price More Price(25)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML0524 ML277 ≥98% (HPLC) 1401242-74-7 5MG $129 2023-06-20 Buy
Sigma-Aldrich SML0524 ML277 ≥98% (HPLC) 1401242-74-7 25MG $510 2023-06-20 Buy
Cayman Chemical 15193 ML-277 ≥95% 1401242-74-7 1mg $44 2024-03-01 Buy
Cayman Chemical 15193 ML-277 ≥95% 1401242-74-7 5mg $118 2024-03-01 Buy
Cayman Chemical 15193 ML-277 ≥95% 1401242-74-7 10mg $172 2024-03-01 Buy
Product number Packaging Price Buy
SML0524 5MG $129 Buy
SML0524 25MG $510 Buy
15193 1mg $44 Buy
15193 5mg $118 Buy
15193 10mg $172 Buy

ML277 Chemical Properties,Uses,Production

Description

Potassium (K+) channels are categorized by their mode of activation and the number of transmembrane segments. The voltage-gated six-transmembrane K+ channels include KCNQ1, first recognized for its role in cardiac function and subsequently in hearing, gastrointestinal chloride secretion, and other processes. ML-277 is a potent activator of KCNQ1 channels (EC50 = 260 nM). The EC50 value of this compound at the related channels KCNQ2, KCNQ4, and hERG exceeds 30 μM. ML-277 potentiates both homomultimeric KCNQ1 channels and unsaturated heteromultimeric (KCNQ1/KCNE1) channels in model cardiomyocytes and augments delayed rectifier K+ current in cultured human cardiomyocytes.

Uses

ML277 has been used as the KCNQ1 activator to treat?cells in lung metastasis?assay.

Biochem/physiol Actions

ML277 is a potent activator of KCNQ1 (Kv7.1) channels with >100-fold selectivity versus KCNQ2 and KCNQ4 and no activity against the hERG potassium channel up to 30 μM. KCNQ1 is a voltage-gated potassium channel required for repolarization phase of the cardiac action potential. Mutations in the KCNQ1 gene are associated with long QT syndrome (LQTS), a disorder in which the heart muscles take longer than normal to recover after each heart beat and can lead to dangerous arrhythmias such as atrial fibrillation. Activators of KCNQ1 channels could have potential use in treatments of LQTS. ML277 is the first selective and potent activator found, with an EC50 of 260 nM.

storage

Store at -20°C

ML277 synthesis

2104-04-3
1401242-74-7
Synthesis of ML277 from 4-(4-Methoxyphenyl)-1,3-thiazol-2-amine

ML277 Preparation Products And Raw materials

Raw materials

4-(4-Methoxyphenyl)-1,3-thiazol-2-amine (R)-(+)-N-Boc-2-piperidinecarboxylic acid Tosyl chloride

Preparation Products

ML277 Suppliers

Global( 100)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32480 60
career henan chemical co 		+86-0371-86658258 15093356674; factory@coreychem.com China 29826 58
Chemia Biotechnology（Shanghai） Co., Ltd 		+8613816753574 info@chemia-pharm.com CHINA 311 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10523 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
TargetMol Chemicals Inc. 		+1-781-999-5354 support@targetmol.com United States 19973 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054 trendseenbio@gmail.com China 11681 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525 masar@topule.com China 8474 58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd 		+86-18341751992 +86-15382112998 757984502@qq.com China 892 58
LEAPCHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 43348 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Chemia Biotechnology（Shanghai） Co., Ltd 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
InvivoChem 		58
TargetMol Chemicals Inc. 		58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		58
Wuhan Topule Biopharmaceutical Co., Ltd 		58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd 		58
LEAPCHEM CO., LTD. 		58

View Lastest Price from ML277 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(2R)-N-[4-(4-Methoxyphenyl)-1,3-thiazol-2-yl]-1-[(4-methylphenyl) sulfonyl]-2-piperidinecarboxamide pictures 2020-01-02 (2R)-N-[4-(4-Methoxyphenyl)-1,3-thiazol-2-yl]-1-[(4-methylphenyl) sulfonyl]-2-piperidinecarboxamide
1401242-74-7
 US $1.00 / KG 1KG Min98% HPLC g/kg/ton Career Henan Chemical Co

ML277 Spectrum

ML277(1401242-74-7)1HNMR

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VU0458298-2, VU0458298-3 ML277 (2R)-N-[4-(4-Methoxyphenyl)-1,3-thiazol-2-yl]-1-(4-methylphenyl)sulfonylpiperidine-2-carboxamide (R)-N-(4-(4-Methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide CID-53347902 ML277;ML 277; ML-277 (2R)-N-[4-(4-Methoxyphenyl)-1,3-thiazol-2-yl]-1-[(4-methylphenyl) sulfonyl]-2-piperidinecarboxamide (2R)-N-[4-(4-Methoxyphenyl)-2-thiazolyl]-1-[(4-methylphenyl)sulfonyl]-2-piperidinecarboxamide ML-277;ML 277;CID-53347902;CID53347902;CID 53347902 2-Piperidinecarboxamide, N-[4-(4-methoxyphenyl)-2-thiazolyl]-1-[(4-methylphenyl)sulfonyl]-, (2R)- N-[4-(4-methoxy-phenyl)-thiazol-2-]-1-[1-(4-Methylbenzenesulfonyl) pip- eridine -2-] formamide 1401242-74-7 API