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2-Bromo-3'-chloropropiophenone

2-Bromo-3'-chloropropiophenone structure

CAS No.: 34911-51-8

Chemical Name:: 2-Bromo-3'-chloropropiophenone

Synonyms: 2-BROMO-1-(3-CHLOROPHENYL)PROPAN-1-ONE;DK749;2B3CP;2-Bromo Bupropion;Bupropion Impurity 5;Bupropion Impurity 42;Bupropion impurity M1-9;Bromo Chloropropiophenone;Bupropion 2-BroMo IMpurity;Bupropion Related Compound G

CBNumber:: CB3271779

Molecular Formula:: C9H8BrClO

Molecular Weight:: 247.52

MDL Number:: MFCD03701150

MOL File:: 34911-51-8.mol

MSDS File:: SDS

Last updated:2024-04-16 14:59:45

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2-Bromo-3'-chloropropiophenone Properties

Boiling point	148-148.5 °C(Press: 9 Torr)
Density	1.532
refractive index	1.5770
storage temp.	Refrigerator, Under Inert Atmosphere
solubility	Soluble in acetonitrile, chloroform, dichloromethane and ethyl acetate.
form	Liquid
color	Colorless to pale yellow
InChI	InChI=1S/C9H8BrClO/c1-6(10)9(12)7-3-2-4-8(11)5-7/h2-6H,1H3
InChIKey	OFNMQTRHMBQQEA-UHFFFAOYSA-N
SMILES	C(C1=CC=CC(Cl)=C1)(=O)C(Br)C
CAS DataBase Reference	34911-51-8(CAS DataBase Reference)
FDA UNII	3OP1CI6QQX

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Hazard statements

H315-H319-H335

Precautionary statements

P261-P280a-P304+P340-P305+P351+P338-P405-P501a

HazardClass

IRRITANT

HS Code

2914790000

NFPA 704

	1
2		0

2-Bromo-3'-chloropropiophenone price More Price(18)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Alfa Aesar	H64999	2-Bromo-3'-chloropropiophenone, 98%	34911-51-8	1g	$29.65	2024-03-01	Buy
Alfa Aesar	H64999	2-Bromo-3'-chloropropiophenone, 98%	34911-51-8	5g	$114.65	2024-03-01	Buy
TRC	C365035	3’-Chloro-2-bromopropiophenone	34911-51-8	1g	$520	2021-12-16	Buy
Biosynth Carbosynth	FC20015	3'-Chloro-2-bromopropiophenone	34911-51-8	1g	$600.6	2021-12-16	Buy
American Custom Chemicals Corporation	API0045851	BUPROPION RELATED COMPOUND G 95.00%	34911-51-8	5MG	$620	2021-12-16	Buy

Product number	Packaging	Price	Buy
H64999	1g	$29.65	Buy
H64999	5g	$114.65	Buy
C365035	1g	$520	Buy
FC20015	1g	$600.6	Buy
API0045851	5MG	$620	Buy

2-Bromo-3'-chloropropiophenone Chemical Properties,Uses,Production

Chemical Properties

Yellow Oil

Uses

It used as an important intermediate for raw material and intermediate used in organic synthesis agrochemical, pharmaceutical and dyestuff field.

Definition

2-Bromo-3'-chloropropiophenone (BCP), a yellow oil, is an intermediate used in the synthesis of bupropion and is also found as an impurity of bupropion hydrochloride. Bupropion is a second-generation antidepressant that was originally approved by the United States Food and Drug Administration (FDA) in 1985. It is a norepinephrine and dopamine transporter inhibitor and an antagonist at neuronal nicotinic acetylcholine receptors. Bupropion is also approved for smoking cessation[1].

Safety

The current United States Pharmacopeia (USP) specification is for no more than 0.1% BCP in the bupropion hydrochloride monograph. The Material Safety Data Sheet from a manufacturer indicates that BCP is irritating to the eyes, respiratory system, and skin. 2-Bromo-3'-chloropropiophenone was mutagenic with S9 metabolic activation, increasing the mutant frequencies in a concentration-dependent manner, up to 22- and 145-fold induction over the controls in Salmonella strains TA100 and TA1535, respectively. BCP was also positive in the in vitro micronucleus assay, resulting in up to 3.3- and 5.1-fold increase of micronucleus frequency for treatments in the absence and presence of S9, respectively; and 9.9- and 7.4-fold increase of aneuploidies without and with S9, respectively. The addition of N-acetyl-l-cysteine, an antioxidant, reduced the genotoxicity of BCP in both assays. Further studies showed that BCP treatment resulted in induction of reactive oxygen species (ROS) in the TK6 cells. The results suggest that BCP is mutagenic, clastogenic, and aneugenic, and that these activities are mediated via generation of reactive metabolites[1].

References

[1] Meng, Fanxue , et al. "Genotoxicity of 2-bromo-3′-chloropropiophenone." Toxicology & Applied Pharmacology 270.2(2013):158-163.

2-Bromo-3'-chloropropiophenone synthesis

Synthesis of 2-Bromo-3'-chloropropiophenone from Chlorobenzene

2-Bromo-3'-chloropropiophenone Preparation Products And Raw materials

Raw materials

Benzene, 1-chloro-3-(1-propen-1-yl)- 3'-Chloropropiophenone 3'-AMINOPROPIOPHENONE 3-Nitropropiophenone Propiophenone

Chlorobenzene

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Preparation Products

2-Bromo-3'-chloropropiophenone Suppliers

Global( 234)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Nanjing Deda New Material Technology Co., Ltd	+8613223293093	bella@njdeda.com	China	81	58
Shanghai Worldyang Chemical Co.,Ltd.	,+86-21-56795779; +8613651600618	sales@worldyachem.com	China	879	58
Nanjing Deda New Material Technology Ltd.	+8613223281135	niki@njdeda.com	China	76	58
Wuhan Aoliqisi New Material Technology Co., Ltd.	+86-13545906766; +8613545906766	sales@whaop.com	China	265	58
Wuhan Ruichi Technology Co., Ltd	+8613545065237	admin@whrchem.com	China	164	58
Dorne Chemical Technology co. LTD	+86-13583358881 +86-18560316533	Ethan@dornechem.com	China	294	58
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971 +86-17331933971	deasea125996@gmail.com	China	2503	58
Anhui Zhongda Biotechnology Co., Ltd	+8615689548120	linda@zhongda-biotech.com	China	204	58
Hunan aslsen technology co.,ltd	+8619313031929	aslsd@aslsen.com	China	128	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60

Supplier	Advantage
Nanjing Deda New Material Technology Co., Ltd	58
Shanghai Worldyang Chemical Co.,Ltd.	58
Nanjing Deda New Material Technology Ltd.	58
Wuhan Aoliqisi New Material Technology Co., Ltd.	58
Wuhan Ruichi Technology Co., Ltd	58
Dorne Chemical Technology co. LTD	58
Henan Bao Enluo International TradeCo.，LTD	58
Anhui Zhongda Biotechnology Co., Ltd	58
Hunan aslsen technology co.,ltd	58
Capot Chemical Co.,Ltd.	60

View Lastest Price from 2-Bromo-3'-chloropropiophenone manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-26	2-Bromo-3'-chloropropiophenone 34911-51-8	US $1.00 / g	1g	99%	1000kg	Dorne Chemical Technology co. LTD
2024-04-26	2-Bromo-3'-chloropropiophenone 34911-51-8	US $15.00-10.00 / kg	1kg	99.5	10 ton per month	Nanjing Deda New Material Technology Co., Ltd
2024-04-26	2-Bromo-3'-chloropropiophenone 34911-51-8	US $15.00-10.00 / kg	1kg	99.5	10 ton per month	Nanjing Deda New Material Technology Co., Ltd

2-Bromo-3'-chloropropiophenone
34911-51-8
US $1.00 / g
99%
Dorne Chemical Technology co. LTD

2-Bromo-3'-chloropropiophenone
34911-51-8
US $15.00-10.00 / kg
99.5
Nanjing Deda New Material Technology Co., Ltd

2-Bromo-3'-chloropropiophenone
34911-51-8
US $15.00-10.00 / kg
99.5
Nanjing Deda New Material Technology Co., Ltd

34911-51-8(2-Bromo-3'-chloropropiophenone)Related Search:

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Pyruvic acid Acetylacetone 3-Chloropropiophenone Propane 1-(3-Chlorophenyl)-1,2-propanedione

Bupropion Impurity 1 2-(tert-Butylamino)-3',5'-dichloropropiophenone Hydrochloride Bupropion IMpurity ((3R,5RS,6RS)-6-(3-Chlorophenyl)-6-Hydroxy-5-Methyl-3-ThioMorpholine Carboxylic Acid) (3S,5S,6S)-Bupropion Impurity 3-Chlorobenzoic acid

Bupropion Impurity 6 Bupropion Impurity 10 (3S,5R,6R)-Bupropion Impurity

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2-BROMO-1-(3-CHLOROPHENYL)-1-PROPANONE 2-BROMO-3'-CHLOROPROPIOPHENONE 3'-CHLORO-2-BROMOPROPIOPHENONE 3'-Chloro-α-bromopropiophenone 1-Propanone,2-broMo-1-(3-chlorophenyl)- α-BroMo-3-chloropropiophenone Bupropion 2-BroMo IMpurity Bupropion Impurity 5 Bupropion impurity M1-9 2-Bromo-3'-chloropropiophenone, 2-Bromo-1-(3-chlorophenyl)-1-propanone 2-Bromo-1-(3-chlorophenyl)propan-1- 2-Bromo Bupropion Bupropion Impurity 42 2-Bromo-3'-chloropropiophenone,98% 2-Bromo Bupropion ImpurityQ: What is 2-Bromo Bupropion Impurity Q: What is the CAS Number of 2-Bromo Bupropion Impurity Q: What is the storage condition of 2-Bromo Bupropion Impurity Q: What are the applications of 2-Bromo Bupropion Impurity 2-BROMO-1-(3-CHLOROPHENYL)PROPAN-1-ONE Bupropion Related Compound G Bupropion USP Related Compound G DK749 Bromo Chloropropiophenone 2-Bromo-3’-Chloropropiophenone (Intermediate of Bupropion ) Bupropion Related Compound G (50 mg) (2-Bromo-1-(3-chlorophenyl)propan-1-one) 2B3CP 2-Bromo-3'-chloropropiophenone 34911-51-8 34911-54-8 C9H9BrClC Aromatics