DBCO-amine
- CAS No.
- 1255942-06-3
- Chemical Name:
- DBCO-amine
- Synonyms
- DBCO-NH2;DBCO-amine;DBCO-CH2CH2NH2;DBCO-(CH2)2-NH2;ADIBO-CH2CH2NH2·TFA;DBCO-(CH2)3-NH2.TFA;DBCO-(CH2)2-NH2.TFA;Dibenzocyclooctyne-amine;DBCO-Amine (DBCO amine);Azadibenzocylooctyne-amine
- CBNumber:
- CB32730210
- Molecular Formula:
- C18H16N2O
- Molecular Weight:
- 276.33
- MDL Number:
- MFCD22380759
- MOL File:
- 1255942-06-3.mol
| Melting point | 86-96°C |
|---|---|
| Boiling point | 549.9±50.0 °C(Predicted) |
| Density | 1.25±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| pka | 8.81±0.10(Predicted) |
| form | Solid |
| color | Yellow to Orange |
| InChI | InChI=1S/C18H16N2O/c19-12-11-18(21)20-13-16-7-2-1-5-14(16)9-10-15-6-3-4-8-17(15)20/h1-8H,11-13,19H2 |
| InChIKey | PQFQVUMDOWUGMK-CHMOPDDRSA-N |
| SMILES | C(N1CC2=CC=CC=C2C#CC2=CC=CC=C12)(=O)CCN |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a |
| WGK Germany | 3 |
| HS Code | 29339900 |
DBCO-amine price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 761540 | Dibenzocyclooctyne-amine for Copper-free Click Chemistry | 1255942-06-3 | 10mg | $64.2 | 2024-03-01 | Buy |
| Sigma-Aldrich | 761540 | Dibenzocyclooctyne-amine for Copper-free Click Chemistry | 1255942-06-3 | 100mg | $488 | 2024-03-01 | Buy |
| Alfa Aesar | J65637 | Azadibenzocyclooctyne-amine | 1255942-06-3 | 25mg | $178 | 2024-03-01 | Buy |
| Alfa Aesar | J65637 | Azadibenzocyclooctyne-amine | 1255942-06-3 | 100mg | $473 | 2024-03-01 | Buy |
| TRC | D195013 | DBCO-Amine | 1255942-06-3 | 50mg | $900 | 2021-12-16 | Buy |
DBCO-amine Chemical Properties,Uses,Production
Description
DBCO-amine is a simple building block containing a DBCO moiety and will add minimal spacer to the modified molecules. In the presence of activators such as EDC or HATU, this reagent can be used to derivatize carboxyl groups or activated esters (e.g. The NHS ester) through a stable amide bond. DBCO is commonly used for copper-free Click Chemistry reactions.
Uses
Azadibenzocyclooctyne amine is a carbonyl reactive reagent used to incorporate ADIBO into organic compounds, surfaces or particlesAzadibenzocyclooctyne amine is widely useful in strain-promoted copper-free azide-alkyne cycloaddition reactions. It reacts with azide functionalized compounds or bimolecules to give stable triazole linkage without a need for a Cu(I) catalyst.
Uses
DBCO-Amine was useful for the study of labelled T-cells, which were used to predict the therapeutic efficacy of adoptive T-cell therapy.
Properties and Applications
DBCO-amine is an aza-dibenzocyclooctyne (DBCO) product used for strain-promoted azide-alkyne cycloaddition (SPAAC, also known as “copper-free click chemistry”). The DBCO moiety reacts selectively with azides via SPAAC to form stable triazole linkages. The amine terminus of the molecule reacts with carboxylic acids and their active esters to form stable amide bonds. Insoluble in water, DBCO-amine is slightly soluble to sparingly soluble in most organic solvents. It recommends dimethylsulfoxide (DMSO), N, N’-dimethylformamide (DMF), or N, N’-dimethylacetamide (DMAC) as solvents for this product. DBCO-amine is relatively insensitive to bases and can be used in the presence of aqueous bases. This product is acid-sensitive. It should not be subjected to pH <5 during reaction or workup. The product should always be stored at -20°C when not in use.
DBCO-amine Preparation Products And Raw materials
DBCO-amine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| HUBEI DING KOSIN TECHNOLOGY | +8613524650931 | jason@kosinbio.com | China | 953 | 58 |
| Xian confluore Biological Technology Co., Ltd. | +86-15680926068 +86-15680926068 | 1924344760@confluore.cn | China | 2893 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 7613 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| 9i LLC | +18039569191 | MWan@NiNeiLab.com | United States | 418 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 6992 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 12477 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
View Lastest Price from DBCO-amine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-03-29 | DBCO-amine
1255942-06-3
|
US $6.00-1.00 / KG | 1KG | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2024-03-20 | DBCO-amine
1255942-06-3
|
US $0.00 / mg | 100mg | >99.00% | 1g | Xian confluore Biological Technology Co., Ltd. |
-
- DBCO-amine
1255942-06-3
- US $6.00-1.00 / KG
- 99%
- Henan Fengda Chemical Co., Ltd
-
- DBCO-amine
1255942-06-3
- US $0.00 / mg
- >99.00%
- Xian confluore Biological Technology Co., Ltd.