Ivosidenib
- CAS No.
- 1448347-49-6
- Chemical Name:
- Ivosidenib
- Synonyms
- Ivosidenib;lvosidenib;RG120;CS-1721;EOS-60845;RG120 100MG;AG120;AG 120;AG-120 (RG120);Ivosidenib 13C5;13C5]-Ivosidenib
- CBNumber:
- CB32738771
- Molecular Formula:
- C28H22ClF3N6O3
- Molecular Weight:
- 582.96
- MDL Number:
- MFCD29036964
- MOL File:
- 1448347-49-6.mol
| Melting point | 151-173°C |
|---|---|
| Boiling point | 854.3±65.0 °C(Predicted) |
| Density | 1.51±0.1 g/cm3(Predicted) |
| storage temp. | -20°C Freezer, Under inert atmosphere |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| pka | 11.58±0.40(Predicted) |
| form | Solid |
| color | White to Off-White |
| NCI Dictionary of Cancer Terms | ivosidenib |
| FDA UNII | Q2PCN8MAM6 |
| NCI Drug Dictionary | ivosidenib |
| ATC code | L01XX62 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P280-P305+P351+P338 | |||||||||
| NFPA 704 |
|
Ivosidenib price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 19894 | AG-120 ≥98% | 1448347-49-6 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 19894 | AG-120 ≥98% | 1448347-49-6 | 5mg | $100 | 2024-03-01 | Buy |
| Cayman Chemical | 19894 | AG-120 ≥98% | 1448347-49-6 | 10mg | $184 | 2024-03-01 | Buy |
| Cayman Chemical | 19894 | AG-120 ≥98% | 1448347-49-6 | 25mg | $381 | 2024-03-01 | Buy |
| ChemScene | CS-5122 | Ivosidenib 99.78% | 1448347-49-6 | 50mg | $384 | 2021-12-16 | Buy |
Ivosidenib Chemical Properties,Uses,Production
Description
AG-120 is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1) that specifically inhibits a mutated form of IDH1 in the cytoplasm, preventing the formation of 2-hydroxyglutarate. AG-120 may induce cellular differentiation as well as inhibit proliferation in IDH1-expressing tumor cells.
Uses
Ivosidenib is a first-in-class mutant IDH1 inhibitor for the treatment of IDH1 mutant cancers.
Definition
ChEBI: Ivosidenib is a tertiary carboxamide resulting from the formal condensation of the carboxy group of (2S)-1-(4-cyanopyridin-2-yl)-5-oxopyrrolidine-2-carboxylic acid with the secondary amino group of (2S)-2-(2-chlorophenyl)-N-(3,3-difluorocyclobutyl)-2-[(5-fluoropyridin-3-yl)amino]acetamide. It is approved by the FDA for the treatment of acute myeloid leukemia (AML) in patients with an isocitrate dehydrogenase-1 (IDH1) mutation. It has a role as an antineoplastic agent and an EC 1.1.1.42 (isocitrate dehydrogenase) inhibitor. It is a member of monochlorobenzenes, a cyanopyridine, a member of pyrrolidin-2-ones, an organofluorine compound, a tertiary carboxamide and a secondary carboxamide.
in vitro
tf-1 cells or primary human aml patient samples expressing mutant idh1 were treated with ag-120, and the results showed that in tf-1 idh1-r132h cells, ag-120 was able to decrease the intracellular 2-hg levels, inhibit growth factor independent proliferation and restore erythropoietin-induced differentiation [1].
IC 50
< 100 nm
storage
Store at -20°C
References
[1] erica hansen et al. ag-120, an oral, selective, first-in-class, potent inhibitor of mutant idh1, reduces intracellular 2hg and induces cellular differentiation in tf-1 r132h cells and primary human idh1 mutant aml patient samples treated ex vivo. blood 2014 124:3734.
[2] http://www. aacr.org/newsroom/pages/news-release-detail.aspx itemid=789#.wlauom997iu
Ivosidenib Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9348 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Lianyungang happen teng technology co., LTD | 15950718863 | wang666xt@163.com | CHINA | 295 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| CR Corporation Lomited | fred.wen@crcorporation.cn | CHINA | 12069 | 58 | |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
Related articles
- The synthesis method of Ivosidenib
- Ivosidenib is a first-in-class, oral small molecule, potent and selective inhibitor of mutant isocitrate dehydrogenase 1 (mIDH....
- Dec 28，2023
