ChemicalBook >> CAS DataBase List >>BOC-L-Proline
BOC-L-Proline
- CAS No.
- 15761-39-4
- Chemical Name:
- BOC-L-Proline
- Synonyms
- BOC-PRO-OH;BOC-PRO;N-BOC-L-PROLINE;BOC-L-PRO;BOC-L-PRO-OH;N-(TERT-BUTOXYCARBONYL)-L-PROLINE;N-BOC-PROLINE;BOC-PROLINE;(S)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid;(2S)-1-tert-butoxycarbonylpyrrolidine-2-carboxylic acid
- CBNumber:
- CB3274189
- Molecular Formula:
- C10H17NO4
- Molecular Weight:
- 215.25
- MDL Number:
- MFCD00037324
- MOL File:
- 15761-39-4.mol
- MSDS File:
- SDS
Last updated:2023-08-04 21:29:34
| Melting point | 133-135 °C(lit.) |
|---|---|
| Boiling point | 355.52°C (rough estimate) |
| alpha | -60.5 º (c=1, HAc) |
| Density | 1.1835 (rough estimate) |
| refractive index | -60 ° (C=2, AcOH) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Soluble in acetic acid. |
| form | Crystals or Crystalline Powder |
| pka | 4.01±0.20(Predicted) |
| color | White |
| optical activity | [α]20/D 61±2°, c = 2% in acetic acid |
| BRN | 15828 |
| InChIKey | ZQEBQGAAWMOMAI-ZETCQYMHSA-N |
| CAS DataBase Reference | 15761-39-4(CAS DataBase Reference) |
| EPA Substance Registry System | 1,2-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (2S)- (15761-39-4) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 20/21/22-36/37/38 | |||||||||
| Safety Statements | 24/25-36-26 | |||||||||
| WGK Germany | 3 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 2933 99 80 | |||||||||
| HazardClass | IRRITANT | |||||||||
| NFPA 704 |
|
BOC-L-Proline price More Price(52)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 8.53003 | Boc-Pro-OH Novabiochem? | 15761-39-4 | 25g | $56.1 | 2024-03-01 | Buy |
| Sigma-Aldrich | 15490 | Boc-Pro-OH ≥99.0% (T) | 15761-39-4 | 5g | $36.4 | 2024-03-01 | Buy |
| Sigma-Aldrich | 8.53003 | Boc-Pro-OH Novabiochem? | 15761-39-4 | 100g | $129 | 2024-03-01 | Buy |
| TCI Chemical | B1188 | N-(tert-Butoxycarbonyl)-L-proline >99.0%(T) | 15761-39-4 | 5g | $20 | 2024-03-01 | Buy |
| TCI Chemical | B1188 | N-(tert-Butoxycarbonyl)-L-proline >99.0%(T) | 15761-39-4 | 25g | $58 | 2024-03-01 | Buy |
BOC-L-Proline Chemical Properties,Uses,Production
Description
N-Boc-L-proline is a synthetic intermediate. It has been used in the synthesis of enantioselective catalysts for aldol reactions and hepatitis C virus (HCV) NS5A inhibitors.
Chemical Properties
White to off-white microcrystalline powder
Uses
N-Boc-L-proline is used as an intermediate in organic synthesis. It is also used to prepare daclatasvir, which inhibits the hepatitis C virus (HCV) non-structural 5A (NS5A) protein. Further, it is used as a drug in the treatment of hepatitis C virus (HCV).
Preparation
Triethylamine (16.5 mL, 0.12 mmol) was added dropwise over a period of 10 min to a stirred, ice-cold suspension of l-proline (10.0 g, 8.7 mmol) in dichloromethane (200 mL) in a 500-mL three-necked, round-bottomed flask. A solution of Boc2O (28.3 g, 0.13 mmol) in dichloromethane (100 mL) was then added over a period of 10 min and the mixture was stirred for 2.5 h. Thereafter, 10% aqueous citric acid (50 mL) was added, and the dichloromethane layer was washed with saturated brine (2×50 mL) and with water (50 mL). After drying the organic phase over magnesium sulfate, the solvent was evaporated and the residue was taken up in hot ethyl acetate. Dilution of this solution with hexane gave the product, N-tertbutoxycarbonyl- L-proline (17.8 g, 95%); mp 138–140℃; TLC (silica gel): Rf=0:36 (EtOAc/MeOH, 1:1).
BOC-L-Proline Preparation Products And Raw materials
Raw materials
Preparation Products
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Global( 692)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 +86-17331933971 | deasea125996@gmail.com | China | 2503 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 7845 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15928 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9348 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| AB PharmaTech,LLC | 323-480-4688 | United States | 989 | 55 | |
| Zjartschem | +86-571-8723 8903 jocelynpan@zjarts.com | jocelynpan@zjarts.com | CHINA | 993 | 58 |
| Shanxi Naipu Import and Export Co.,Ltd | +86-13734021967 +8613734021967 | kaia@neputrading.com | China | 1011 | 58 |
View Lastest Price from BOC-L-Proline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-01-14 | Boc-L-Proline
15761-39-4
|
US $5.00-0.50 / KG | 1KG | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2023-08-16 | Boc-L-Proline
15761-39-4
|
US $80.00 / KG | 1KG | >99% | 20tons | Weijer International Trade (Hebei) Co., Ltd | |
 |
2023-08-05 | BOC-L-Proline
15761-39-4
|
US $0.00-0.00 / kg | 1kg | 0.99 | 50000kg | Hebei Kingfiner Technology Development Co. , Ltd. |
-
- Boc-L-Proline
15761-39-4
- US $5.00-0.50 / KG
- 99%
- Henan Fengda Chemical Co., Ltd
-
- Boc-L-Proline
15761-39-4
- US $80.00 / KG
- >99%
- Weijer International Trade (Hebei) Co., Ltd
-
- BOC-L-Proline
15761-39-4
- US $0.00-0.00 / kg
- 0.99
- Hebei Kingfiner Technology Development Co. , Ltd.
15761-39-4(BOC-L-Proline)Related Search:
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BOC-L-PROLINE-OH
L-Proline, N-BOC protected, (2S)-1-(tert-Butoxycarbonyl)pyrrolidine-2-carboxylic acid
L-PROLINE-N-T-BOC
BOC-L-Proline, 99+% 25GR
(S)-1-(tert-buto×ycarbonyl)pyrrolidine-2-carbo×ylic acid
N-Boc-L-Proline
N-Boc-L-proline
Boc-Pro-OH
N-(tert-Butoxycarbonyl)-L-proline
N-(tert-Butoxycarbonyl)-L-proline
(S)-Pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester
The BOC-L- pro
N-(tert-Butoxycarbonyl)-L-proline, 99.0%(T)
Boc-L-Proline SynonyMs N-(tert-Butoxycarbonyl)-L-proline
Boc-Pro-OH >=99.0% (T)
Daclatasvir Intermediates 3
Vildagliptin Impurity 15
1-tert-Butyloxycarbonyl-L-proline
(S)-Boc-pyrrolidine-2-carboxylic acid
Boc-L-proline≥ 98% (HPLC)
TBOC-L-PROLINE
T-BUTYLOXYCARBONYL-L-PROLINE
RARECHEM AL BO 1463
1,2-PYRROLIDINEDICARBOXYLIC ACID, 1-(1,1-DIMETHYLETHYL) ESTER, (2S)-
1-(tert-butyl) hydrogen (S)-pyrrolidine-1,2-dicarboxylate
BOC-L-Proline, 99+%
Boc-DL-Proline-OH
TERT-BUTYLOXYCARBONYLPROLINE
N-ALPHA-T-BUTYLOXYCARBONYL-L-PROLINE
Boc-Pro-OH (Boc-L-Proline
N-(tert-Butoxycarbonyl)-L-proline, Boc-L-proline
(2S)-1-[(2-Methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid
Butoxycarbonylproilne
N-(tert-Butoxycarbonyl)-L-proline ,98.5%
(2S)-1-(tert-Butyloxycarbonyl)pyrrolidine-2α-carboxylic acid
(2S)-1,2-Pyrrolidinedicarbonic acid 1-tert-butyl ester
Boc-Pro-OH (Boc-L-Proline: N-(tert-Butoxycarbonyl)-L-proline)
(2S)-Pyrrolidine-2-carboxylic acid, N-BOC protected
(S)-1,2-Pyrrolidinedicarboxylic acid 1-(1,1-dimethylethyl) ester
N-(TERT-BUTOXYCARBONYL)-L-PROILNE
N-(TERT-BUTYLOXYCARBONYL)-L-PROLINE
N-T-BUTOXYCARBONYL-L-PROLINE
N-T-BOC-L-PROLINE
n-alpha-tert-boc-l-proline
N-ALPHA-TERT-BUTYLOXYCARBONYL-L-PROLINE
N-ALPHA-T-BUTOXYCARBONYL-L-PYRROLIDINE-2-CARBOXYLIC ACID
N-ALPHA-T-BUTOXYCARBONYL-L-PROLINE
N-ALPHA-T-BOC-L-PROLINE
BOC-L-PROLINE extrapure
1-Tert-Butoxycarbonyl-L-proline
Boc-L-proline ,98.5%
BOC-PYRD(2)-OH
BOC-L-PROLINE
1-(1,1-dimethylethyl)ester,(s)-2-pyrrolidinedicarboxylicacid
(Tert-Butoxy)Carbonyl Pro-OH
N-(tert-Butoxycarbonyl)-L-proline>
BOC-L-Proline USP/EP/BP
N-(tert-butoxycarbonyl)-laevo-proline
BOC-L-PRO
N-BOC-PROLINE