ChemicalBook >> CAS DataBase List >>BOC-L-Proline

BOC-L-Proline

BOC-L-Proline structure

CAS No.: 15761-39-4

Chemical Name:: BOC-L-Proline

Synonyms: BOC-PRO-OH;BOC-PRO;N-BOC-L-PROLINE;BOC-L-PRO;BOC-L-PRO-OH;N-(TERT-BUTOXYCARBONYL)-L-PROLINE;N-BOC-PROLINE;BOC-PROLINE;(S)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid;(2S)-1-tert-butoxycarbonylpyrrolidine-2-carboxylic acid

CBNumber:: CB3274189

Molecular Formula:: C10H17NO4

Molecular Weight:: 215.25

MDL Number:: MFCD00037324

MOL File:: 15761-39-4.mol

MSDS File:: SDS

Last updated:2026-01-13 11:19:40

Product description	Number	Pack Size	Price
Boc-Pro-OH Novabiochem?	8.53003	25g	$61.4
Boc-Pro-OH ≥99.0% (T)	15490	5g	$40
Boc-Pro-OH Novabiochem?	8.53003	100g	$141
N-(tert-Butoxycarbonyl)-L-proline >99.0%(T)	B1188	5g	$19
N-(tert-Butoxycarbonyl)-L-proline >99.0%(T)	B1188	25g	$55
More product size

Request For Quotation

BOC-L-Proline Properties

Melting point	133-135 °C(lit.)
alpha	-60.5 º (c=1, HAc)
Boiling point	355.52°C (rough estimate)
Density	1.1835 (rough estimate)
refractive index	-60 ° (C=2, AcOH)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Soluble in acetic acid.
pka	4.01±0.20(Predicted)
form	Crystals or Crystalline Powder
color	White
optical activity	[α]20/D 61±2°, c = 2% in acetic acid
BRN	15828
Major Application	peptide synthesis
InChI	1S/C10H17NO4/c1-10(2,3)15-9(14)11-6-4-5-7(11)8(12)13/h7H,4-6H2,1-3H3,(H,12,13)/t7-/m0/s1
InChIKey	ZQEBQGAAWMOMAI-ZETCQYMHSA-N
SMILES	CC(C)(C)OC(=O)N1CCC[C@H]1C(O)=O
CAS DataBase Reference	15761-39-4(CAS DataBase Reference)
EPA Substance Registry System	1,2-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (2S)- (15761-39-4)
UNSPSC Code	12352209
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P305+P351+P338

PPE

Eyeshields, Gloves, type N95 (US)

Hazard Codes

Risk Statements

20/21/22-36/37/38

Safety Statements

24/25-36-26

WGK Germany

TSCA

TSCA listed

HS Code

2933 99 80

HazardClass

IRRITANT

Storage Class

11 - Combustible Solids

NFPA 704

	0
0		0

BOC-L-Proline price More Price(54)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	8.53003	Boc-Pro-OH Novabiochem?	15761-39-4	25g	$61.4	2026-03-19	Buy
Sigma-Aldrich	15490	Boc-Pro-OH ≥99.0% (T)	15761-39-4	5g	$40	2026-03-19	Buy
Sigma-Aldrich	8.53003	Boc-Pro-OH Novabiochem?	15761-39-4	100g	$141	2026-03-19	Buy
TCI Chemical	B1188	N-(tert-Butoxycarbonyl)-L-proline >99.0%(T)	15761-39-4	5g	$19	2026-03-19	Buy
TCI Chemical	B1188	N-(tert-Butoxycarbonyl)-L-proline >99.0%(T)	15761-39-4	25g	$55	2026-03-19	Buy

Product number	Packaging	Price	Buy
8.53003	25g	$61.4	Buy
15490	5g	$40	Buy
8.53003	100g	$141	Buy
B1188	5g	$19	Buy
B1188	25g	$55	Buy

BOC-L-Proline Chemical Properties,Uses,Production

Description

N-Boc-L-proline is a synthetic intermediate. It has been used in the synthesis of enantioselective catalysts for aldol reactions and hepatitis C virus (HCV) NS5A inhibitors.

Chemical Properties

White to off-white microcrystalline powder

Uses

N-Boc-L-proline is used as an intermediate in organic synthesis. It is also used to prepare daclatasvir, which inhibits the hepatitis C virus (HCV) non-structural 5A (NS5A) protein. Further, it is used as a drug in the treatment of hepatitis C virus (HCV).

Preparation

Triethylamine (16.5 mL, 0.12 mmol) was added dropwise over a period of 10 min to a stirred, ice-cold suspension of l-proline (10.0 g, 8.7 mmol) in dichloromethane (200 mL) in a 500-mL three-necked, round-bottomed flask. A solution of Boc2O (28.3 g, 0.13 mmol) in dichloromethane (100 mL) was then added over a period of 10 min and the mixture was stirred for 2.5 h. Thereafter, 10% aqueous citric acid (50 mL) was added, and the dichloromethane layer was washed with saturated brine (2×50 mL) and with water (50 mL). After drying the organic phase over magnesium sulfate, the solvent was evaporated and the residue was taken up in hot ethyl acetate. Dilution of this solution with hexane gave the product, N-tertbutoxycarbonyl- L-proline (17.8 g, 95%); mp 138–140℃; TLC (silica gel): Rf=0:36 (EtOAc/MeOH, 1:1).

reaction suitability

reaction type: Boc solid-phase peptide synthesis

References

[1] ALBRECHT BERKESSEL Johann L Burkhard Koch. Proline-Derived N-Sulfonylcarboxamides: Readily Available, Highly Enantioselective and Versatile Catalysts for Direct Aldol Reactions[J]. Advanced Synthesis & Catalysis, 2004, 346 9-10: 1141-1146. DOI: 10.1002/adsc.200404126
[2] JUNXING SHI . Synthesis and biological evaluation of new potent and selective HCV NS5A inhibitors[J]. Bioorganic & Medicinal Chemistry Letters, 2012, 22 10: Pages 3488-3491. DOI: 10.1016/j.bmcl.2012.03.089

BOC-L-Proline Preparation Products And Raw materials

Raw materials

Preparation Products

L-Proline benzyl ester hydrochloride D-1-N-Boc-prolinamide N-BOC PRROLIDIN-2-OL Semax ANGIOTENSIN I, HUMAN

2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Cetrorelix Boc-L-Proline-methyl ester ANGIOTENSIN II, HUMAN (S)-tert-butyl 2-(dimethylcarbamoyl)pyrrolidine-1-carboxylate

1of2

BOC-L-Proline Suppliers

Global( 728)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Anhui Dexinjia Biopharm Co., Ltd	+86-531-82375818 +86-15064153060	sales01@jndxj.com	China	318	58
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971	deasea125996@gmail.com	China	2472	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20124	58
Hebei Zhuanglai Chemical Trading Co Ltd	+86-16264648883	niki@zlchemi.com	China	7245	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29640	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	13815	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21592	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
AB PharmaTech,LLC	323-480-4688	sales@acrospharmatech.com	United States	989	55
Shanxi Naipu Import and Export Co.,Ltd	+86-13734021967 +8613734021967	kaia@neputrading.com	China	1001	58

Supplier	Advantage
Anhui Dexinjia Biopharm Co., Ltd	58
Henan Bao Enluo International TradeCo.，LTD	58
Henan Fengda Chemical Co., Ltd	58
Hebei Zhuanglai Chemical Trading Co Ltd	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
AB PharmaTech,LLC	55
Shanxi Naipu Import and Export Co.,Ltd	58

View Lastest Price from BOC-L-Proline manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-04-20	BOC-L-Proline 15761-39-4	US $0.00 / Kg/Drum	1KG	98%min	500kgs	WUHAN FORTUNA CHEMICAL CO., LTD
2026-02-27	BOC-L-Proline 15761-39-4	US $200.00 / KG	1KG	98%	20TONS	Anhui Dexinjia Biopharm Co., Ltd
2025-09-25	Boc-L-Proline 15761-39-4	US $5.00-0.50 / KG	1KG	99%	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd

BOC-L-Proline
15761-39-4
US $0.00 / Kg/Drum
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

BOC-L-Proline
15761-39-4
US $200.00 / KG
98%
Anhui Dexinjia Biopharm Co., Ltd

Boc-L-Proline
15761-39-4
US $5.00-0.50 / KG
99%
Henan Fengda Chemical Co., Ltd

BOC-L-Proline Spectrum

BOC-L-Proline(15761-39-4)MS BOC-L-Proline(15761-39-4)¹HNMR BOC-L-Proline(15761-39-4)IR1 BOC-L-Proline(15761-39-4)IR2 BOC-L-Proline(15761-39-4)Raman

15761-39-4(BOC-L-Proline)Related Search:

tert-Butyl peroxyacetate Fmoc-Lys(Boc)-OH Boc-Aib-OH Methyl acrylate Dimethyl succinate

Diethylstilbestrol N-Boc-L-valine L-Proline BUTYL OLEATE L-PROLINE-(4-3H(N))

cis-4-Hydroxy-L-proline Olibanum oil D-Proline Tris(trimethylsilyl)phosphate BOC-L-PROLINE AMIDE

RAC 1-METHYL-PYRROLIDINE-2-CARBONITRILE tert-Butanol CHLOROAC-PRO-OH

1of4

BOC-L-PROLINE-OH L-Proline, N-BOC protected, (2S)-1-(tert-Butoxycarbonyl)pyrrolidine-2-carboxylic acid L-PROLINE-N-T-BOC BOC-L-Proline, 99+% 25GR (S)-1-(tert-buto×ycarbonyl)pyrrolidine-2-carbo×ylic acid N-Boc-L-Proline N-Boc-L-proline Boc-Pro-OH N-(tert-Butoxycarbonyl)-L-proline N-(tert-Butoxycarbonyl)-L-proline (S)-Pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester The BOC-L- pro N-(tert-Butoxycarbonyl)-L-proline, 99.0%(T) Boc-L-Proline SynonyMs N-(tert-Butoxycarbonyl)-L-proline Boc-Pro-OH >=99.0% (T) Daclatasvir Intermediates 3 Vildagliptin Impurity 15 1-tert-Butyloxycarbonyl-L-proline (S)-Boc-pyrrolidine-2-carboxylic acid Boc-L-proline≥ 98% (HPLC) TBOC-L-PROLINE T-BUTYLOXYCARBONYL-L-PROLINE RARECHEM AL BO 1463 1,2-PYRROLIDINEDICARBOXYLIC ACID, 1-(1,1-DIMETHYLETHYL) ESTER, (2S)- 1-(tert-butyl) hydrogen (S)-pyrrolidine-1,2-dicarboxylate BOC-L-Proline, 99+% Boc-DL-Proline-OH TERT-BUTYLOXYCARBONYLPROLINE N-ALPHA-T-BUTYLOXYCARBONYL-L-PROLINE Boc-Pro-OH (Boc-L-Proline N-(tert-Butoxycarbonyl)-L-proline, Boc-L-proline (2S)-1-[(2-Methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid Butoxycarbonylproilne N-(tert-Butoxycarbonyl)-L-proline ,98.5% (2S)-1-(tert-Butyloxycarbonyl)pyrrolidine-2α-carboxylic acid (2S)-1,2-Pyrrolidinedicarbonic acid 1-tert-butyl ester Boc-Pro-OH (Boc-L-Proline: N-(tert-Butoxycarbonyl)-L-proline) (2S)-Pyrrolidine-2-carboxylic acid, N-BOC protected (S)-1,2-Pyrrolidinedicarboxylic acid 1-(1,1-dimethylethyl) ester N-(TERT-BUTOXYCARBONYL)-L-PROILNE N-(TERT-BUTYLOXYCARBONYL)-L-PROLINE N-T-BUTOXYCARBONYL-L-PROLINE N-T-BOC-L-PROLINE n-alpha-tert-boc-l-proline N-ALPHA-TERT-BUTYLOXYCARBONYL-L-PROLINE N-ALPHA-T-BUTOXYCARBONYL-L-PYRROLIDINE-2-CARBOXYLIC ACID N-ALPHA-T-BUTOXYCARBONYL-L-PROLINE N-ALPHA-T-BOC-L-PROLINE BOC-L-PROLINE extrapure 1-Tert-Butoxycarbonyl-L-proline Boc-L-proline ,98.5% BOC-PYRD(2)-OH BOC-L-PROLINE 1-(1,1-dimethylethyl)ester,(s)-2-pyrrolidinedicarboxylicacid (Tert-Butoxy)Carbonyl Pro-OH N-(tert-Butoxycarbonyl)-L-proline> BOC-L-Proline USP/EP/BP N-(tert-butoxycarbonyl)-laevo-proline BOC-L-PRO N-BOC-PROLINE