NSC 600157
- CAS No.
- 31083-55-3
- Chemical Name:
- NSC 600157
- Synonyms
- PRT4165;NSC 600157;PRT 4165(NSC 600157);PRT4165 >=98% (HPLC);2-(3-Pyridylmethylene)-1,3-indandione; 2-(pyridin-3-ylmethylidene)indene-1,3-dione;2-(3-Pyridinylmethylene)-1H-indene-1,3(2H)-dione;2-(Pyridin-3-ylmethylene)-1H-indene-1,3(2H)-dione;1H-Indene-1,3(2H)-dione, 2-(3-pyridinylmethylene)-;PRT 4165; PRT-4165; NSC600157; NSC-600157; NSC 600157
- CBNumber:
- CB32750711
- Molecular Formula:
- C15H9NO2
- Molecular Weight:
- 235.24
- MDL Number:
- MFCD00435709
- MOL File:
- 31083-55-3.mol
- MSDS File:
- SDS
| Melting point | 154-161 °C(Solv: ethanol (64-17-5)) |
|---|---|
| Boiling point | 377.63°C (rough estimate) |
| Density | 1.1757 (rough estimate) |
| refractive index | 1.6231 (estimate) |
| storage temp. | 2-8°C |
| solubility | DMSO: soluble20mg/mL, clear |
| form | powder |
| pka | 3.24±0.12(Predicted) |
| color | white to beige |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| FDA UNII | J625FJL5DX |
NSC 600157 price More Price(30)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1013 | PRT4165 ≥98% (HPLC) | 31083-55-3 | 5mg | $106 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML1013 | PRT4165 ≥98% (HPLC) | 31083-55-3 | 25mg | $417 | 2024-03-01 | Buy |
| Sigma-Aldrich | EME00468 | (2E)-2-(Pyridin-3-ylmethylidene)-2,3-dihydro-1H-indene-1,3-dione | 31083-55-3 | 1G | $1210 | 2023-06-20 | Buy |
| Cayman Chemical | 19093 | PRT4165 ≥98% | 31083-55-3 | 5mg | $57 | 2024-03-01 | Buy |
| Cayman Chemical | 19093 | PRT4165 ≥98% | 31083-55-3 | 10mg | $85 | 2024-03-01 | Buy |
NSC 600157 Chemical Properties,Uses,Production
Description
PRT-4165 (31083-55-3) is an inhibitor of Bmi1/Ring1A, subunits of the polycomb repressive complex 1 (PRC1). Inhibits self-ubiquitination (IC50?= 3.9 μM) but does not increase cellular levels of either subunit. Blocks Bmi1/Ring1A-mediated ubiquitination and drug-induced degradation of topoisomerase 2α.1?PRT-4165 inhibits H2A/H2AX ubiquitination via blocking the E3 ubiquitin ligase activity of RNF2 and a Bmi1/RNF2 complex. Blocks polycomb repressor complex (PRC) 1-mediated histone H2A ubiquitination?in vitro?and?in vivo?and as such represents a new tool for studying chromatin remodeling.2
Biochem/physiol Actions
PRT4165 is a potent inhibitor of PRC1 (polycomb-repressive complex 1)-mediated histone H2A ubiquitylation in vivo and in vitro. PRT4165 inhibits the in vitro histone H2A E3 ubiquitin ligase activity of PRC1 components RING1, RNF2, and a BMI1/RNF2 complex. PRT4165 also inhibits DNA double-strand breaks induced ubiquitylation of histone H2AX.
storage
Store at +4°C
References
1) Alchanati?et al. (2009),?The E3 ubiquitin-ligase Bmi1/Ring1A controls the proteasomal degradation of Top2alpha cleavage complex – a potentially new drug target; PLoS One,?4?e8104 2) Ismail?et al.?(2013),?A small molecule inhibitor of polycomb repressive complex 1 inhibits ubiquitin signaling at DNA double-strand breaks; J. Biol. Chem.,?288?26944
NSC 600157 Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 49999 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33349 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
View Lastest Price from NSC 600157 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-12-24 | 2-(pyridin-3-ylmethylidene)indene-1,3-dione
31083-55-3
|
US $1.00 / KG | 1KG | Min98% HPLC | g/kg/ton | Career Henan Chemical Co |
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- 2-(pyridin-3-ylmethylidene)indene-1,3-dione
31083-55-3
- US $1.00 / KG
- Min98% HPLC
- Career Henan Chemical Co