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SPERMINE TETRAHYDROCHLORIDE

SPERMINE TETRAHYDROCHLORIDE structure

CAS No.: 306-67-2

Chemical Name:: SPERMINE TETRAHYDROCHLORIDE

Synonyms: NEURIDINE HYDROCHLORIDE;MUSCULAMINE HYDROCHLORIDE;Spermidine Tetrahydrochloride;Spermine4HCl;SPERMINE HCL;SperMine tetra;Spermidine 4HCl;Spermine, TetraHCl;Spermine-[2H8].4HCl;4-BUTANEDIAMINE 4 HCL

CBNumber:: CB3275333

Molecular Formula:: C10H30Cl4N4

Molecular Weight:: 348.18

MDL Number:: MFCD00012914

MOL File:: 306-67-2.mol

MSDS File:: SDS

Last updated:2025-12-07 19:09:50

Product description	Number	Pack Size	Price
Spermine, Tetrahydrochloride - CAS 306-67-2 - Calbiochem	5677	5G	$327
Spermine tetrahydrochloride EMPROVE? EVOLVE	137141	25g	$3295
Spermine tetrahydrochloride EMPROVE? EVOLVE	137141	100g	$10516
Spermine Tetrahydrochloride [for Protein Research]	P2950	1G	$66
N,N'-Bis(3-aminopropyl)-1,4-butanediamine Tetrahydrochloride >98.0%(N)(T)	B1468	5g	$178

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SPERMINE TETRAHYDROCHLORIDE Properties

Melting point	310-311 °C (dec.)(lit.)
Density	1.01 g/mL at 20 °C
storage temp.	room temp
solubility	H₂O: 1 M at 20 °C, clear, colorless
form	powder
color	White to Almost white
PH	4.5-7.0 (25℃, 1M in H2O)
biological source	synthetic
Water Solubility	Soluble in water (348.2 g/L at 20°C).
λmax	λ: 260 nm Amax: 0.2 λ: 280 nm Amax: 0.15
BRN	3911771
InChI	InChI=1S/C10H26N4.4ClH/c11-5-3-9-13-7-1-2-8-14-10-4-6-12;;;;/h13-14H,1-12H2;4*1H
InChIKey	XLDKUDAXZWHPFH-UHFFFAOYSA-N
SMILES	C(CNCCCN)CCNCCCN.Cl.Cl.Cl.Cl
CAS DataBase Reference	306-67-2(CAS DataBase Reference)
FDA UNII	9CI1570O48
EPA Substance Registry System	Spermine tetrahydrochloride (306-67-2)
UNSPSC Code	12352200
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319

Precautionary statements

P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313

Hazard Codes

Risk Statements

36/38

Safety Statements

26-36

WGK Germany

RTECS

EJ7230000

3-10

TSCA

Yes

HS Code

29212900

NFPA 704

	0
2		0

SPERMINE TETRAHYDROCHLORIDE price More Price(44)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	5677	Spermine, Tetrahydrochloride - CAS 306-67-2 - Calbiochem	306-67-2	5G	$327	2025-07-31	Buy
Sigma-Aldrich	137141	Spermine tetrahydrochloride EMPROVE? EVOLVE	306-67-2	25g	$3295	2025-07-31	Buy
Sigma-Aldrich	137141	Spermine tetrahydrochloride EMPROVE? EVOLVE	306-67-2	100g	$10516	2025-07-31	Buy
TCI Chemical	P2950	Spermine Tetrahydrochloride [for Protein Research]	306-67-2	1G	$66	2025-07-31	Buy
TCI Chemical	B1468	N,N'-Bis(3-aminopropyl)-1,4-butanediamine Tetrahydrochloride >98.0%(N)(T)	306-67-2	5g	$178	2025-07-31	Buy

Product number	Packaging	Price	Buy
5677	5G	$327	Buy
137141	25g	$3295	Buy
137141	100g	$10516	Buy
P2950	1G	$66	Buy
B1468	5g	$178	Buy

SPERMINE TETRAHYDROCHLORIDE Chemical Properties,Uses,Production

Chemical Properties

White to off-white powder

Uses

Used to precipitate DNA from low salt aqueous buffers.

Uses

Spermine tetrahydrochloride was used to precipitate DNA for flow cytometric analysis from fresh frozen breast cancer tissue, archival tissue of salivary gland, renal and thyroid tumors and red blood cells of chicken.

Uses

Spermine Tetrahydrochloride is an inhibitor of NOS1, NMDA, GluR, and PLCα. A useful reactant for Surface-?enhanced Raman spectroscopy (SERS) characterization of abasic sites in DNA duplexes.

Biological Activity

Polyamine which produces a variety of modulatory effects on the NMDA receptor channel, acting through a specific site on the complex which can cause both agonist and antagonist effects.

Biochem/physiol Actions

Mixed NMDA agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).

storage

Desiccate at +4°C

Purification Methods

Its pK values are similar to those of spermidine above. Purify it as for spermidine trihydrochloride above. [Beilstein 4 IV 1301.]

SPERMINE TETRAHYDROCHLORIDE synthesis

Synthesis of SPERMINE TETRAHYDROCHLORIDE from Spermine

SPERMINE TETRAHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Spermine

Preparation Products

SPERMINE TETRAHYDROCHLORIDE Suppliers

Global( 331)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
PNP Biotech Co. Ltd	+8618516098983	sales@pnpbiotech.com	China	1001	58
Hebei Yanxi Chemical Co., Ltd.	+8618531123677	faithe@yan-xi.com	China	5853	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615531151365	mina@chuanghaibio.com	China	18126	58
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971	deasea125996@gmail.com	China	2472	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20136	58
Shaanxi Xianhe Biotech Co., Ltd	+86-17709210191; +8617709210191	Jerry@xhobio.com	China	883	58
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29847	58
Xi'an Kono chem co., Ltd.,	029-86107037 13289246953	info@konochemical.com	China	1169	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-81139210 +86-18192627656	1059@dideu.com	China	3588	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32435	58

Supplier	Advantage
PNP Biotech Co. Ltd	58
Hebei Yanxi Chemical Co., Ltd.	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Henan Bao Enluo International TradeCo.，LTD	58
Henan Fengda Chemical Co., Ltd	58
Shaanxi Xianhe Biotech Co., Ltd	58
career henan chemical co	58
Xi'an Kono chem co., Ltd.,	58
Shaanxi Dideu Medichem Co. Ltd	58
TargetMol Chemicals Inc.	58

View Lastest Price from SPERMINE TETRAHYDROCHLORIDE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-12-10	Spermine tetrahydrochloride 306-67-2	US $0.00 / Gram	500Gram	99%	200kgs	Xi an Biohorlden Industry Trade Co Ltd
2025-12-05	Spermine tetrahydrochloride 306-67-2	US $41.00 / mg		99.75%	10g	TargetMol Chemicals Inc.
2025-11-04	Spermine Tetrahydrochloride (SPT) 306-67-2	US $0.00 / kg	1kg	0.99	1000kg	Shaanxi Xianhe Biotech Co., Ltd

Spermine tetrahydrochloride
306-67-2
US $0.00 / Gram
99%
Xi an Biohorlden Industry Trade Co Ltd

Spermine tetrahydrochloride
306-67-2
US $41.00 / mg
99.75%
TargetMol Chemicals Inc.

Spermine Tetrahydrochloride (SPT)
306-67-2
US $0.00 / kg
0.99
Shaanxi Xianhe Biotech Co., Ltd

SPERMINE TETRAHYDROCHLORIDE Spectrum

SPERMINE TETRAHYDROCHLORIDE(306-67-2)MS SPERMINE TETRAHYDROCHLORIDE(306-67-2)¹HNMR SPERMINE TETRAHYDROCHLORIDE(306-67-2)¹³CNMR SPERMINE TETRAHYDROCHLORIDE(306-67-2)IR1 SPERMINE TETRAHYDROCHLORIDE(306-67-2)IR2 SPERMINE TETRAHYDROCHLORIDE(306-67-2)Raman

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SPERMINE TETRAHYDROCHLORIDE SPERMINE TETRAHYDROCHLORIDE 1,3-DIAMINOPROPANE DIHYDROCHLORIDE 1,4-Diaminobutane dihydrochloride Spermidine

Spermidine trihydrochloride Dipentene N-METHYL-BUTANE-1,4-DIAMINE 2HCL

1of4

N,N'-BIS(3-AMINOPROPYL)-BUTANE-1,4-DIAMINE TETRAHYDROCHLORIDE N,N'-BIS(3-AMINOPROPYL)-1,4-BUTANEDIAMINE 4 H CL N,N'-BIS-(3-AMINOPROPYL)-1,4-DIAMINOBUTANE TETRAHYDROCHLORIDE NEURIDINE TETRAHYDROCHLORIDE MUSCULAMINE TETRAHYDROCHLORIDE SPERMINE HYDROCHLORIDE SPERMINE TETRAHYDROCHLORIDE DIAMINOPROPYLTETRAMETHYLENEDIAMINE HYDROCHLORIDE GERONTINE TETRAHYDROCHLORIDE 1,4-BIS(AMINOPROPYL)BUTANEDIAMINE TETRAHYDROCHLORIDE 1,4-Butanediamine,N,N’-bis(3-aminopropyl)-,tetrahydrochloride n1,n4-bis(3-aMinopropyl)-1,4-butanediaMine hydrochloride N1,N1'-(butane-1,4-diyl)bis(propane-1,3-diaMine) tetrahydrochloride SperMine tetra Spermine tetrahydrochloride solution Spermine tetrahydrochloride Vetec(TM) reagent grade N,N'-Bis(3-aminopropyl)-1,4-butanediamine Tetrahydrochloride SPERMINE TETRAHYDROCHLORIDE BIOREAGE SPERMINE TETRAHYDROCHLORIDE BIOULTRA Spermine tetrahydrochloride≥ 99% (GC) 4-butanediamine,n,n’-bis(3-aminopropyl)-tetrahydrochloride 4,9-diazoniadodecamethylenediammonium tetrachloride Spermine, TetraHCl SPERMINE TETRAHYDROCHLORIDE MOLECULAR*BI OLOGY REAGE SPERMINE TETRAHYDROCHLORIDE, F. MOLE-CUL AR BIOLOGY Spermine tetrahydrochloride 0.1 M Solution Spermine4HCl Additive Screening Solution 31/Fluka kit no 78374, Spermine tetrahydrochloride solution additive screening solution 31/fluka kit no 78374 SPERMINETETRAHYDROCHLORIDE,BIOTECHGRADE SPERMINE HCL Spermine tetrahydrochloride,N,N′-Bis(3-aminopropyl)-1,4-butanediamine tetrahydrochloride Spermine-[2H8].4HCl NEURIDINE HYDROCHLORI Spermine Tetrahydrochloride extrapure, 99% N,N'-Bis(3-aminopropyl)-1,4-butanediamine Tetrahydrochloride > N,N'-Bis(3-aminopropyL )-1,4-butanediamine TetrahydrochL Spermine, Tetrahydrochloride - CAS 306-67-2 - Calbiochem 1,4-Butanediamine,N1,N4-bis(3-aminopropyl)-, hydrochloride (1:4) Spermine Tetra HCl salt NEURIDINE HYDROCHLORIDE MUSCULAMINE HYDROCHLORIDE Spermidine Tetrahydrochloride 4-BUTANEDIAMINE 4 HCL N,N'-Bis(3-aminopropyl)-1,4-butanediamine Tetrahydrochloride Spermidine 4HCl Spermine tetrahydrochloride, polyamine used for precipitation of DNA Gadobutrol Impurity 180 SPERMISPERMINE TETRAHYDROCHLORIDENE TETRAHYDROCHLORIDE 306-67-2 C10H26N44HCl C10H30Cl4N4 C10H26N44ClH C10H26N4HCl C10H30N6O2Cl4 C10H20N44HCl 34818