Doxycycline monohydrate
- CAS No.
- 17086-28-1
- Chemical Name:
- Doxycycline monohydrate
- Synonyms
- DOXYCYCLINE HYDRATE;Power v1;NSC-56228;Strong v1;Doxycyeline HCL;Doxycycline USP;oxycyclinemonohydrate;DOXYCYCLINE MONOHYDRATE;Doxycycline Monohydrate (100 mg);Doxycycline monohydrate USP/EP/BP
- CBNumber:
- CB3289107
- Molecular Formula:
- C22H26N2O9
- Molecular Weight:
- 462.45
- MDL Number:
- MFCD02682958
- MOL File:
- 17086-28-1.mol
- MSDS File:
- SDS
| Melting point | 167-168℃ |
|---|---|
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | DMSO: soluble1mg/mL |
| form | powder or crystals |
| color | Light Yellow |
| Water Solubility | Soluble in ethanol or methanol. Sparingly soluble in water.Soluble in dilute acids, alkali hydroxides and dimethyl sulfoxide. |
| CAS DataBase Reference | 17086-28-1 |
| FDA UNII | N12000U13O |
| Proposition 65 List | Doxycycline Monohydrate (internal use) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264-P270-P301+P312+P330-P501 |
| Hazard Codes | Xi,Xn |
| Risk Statements | 36/37/38-22-63 |
| Safety Statements | 26-36/37 |
| WGK Germany | 3 |
| HS Code | 29413000 |
Doxycycline monohydrate price More Price(14)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | D1822 | Doxycycline monohydrate | 17086-28-1 | 500mg | $76.9 | 2024-03-01 | Buy |
| Alfa Aesar | J63805 | Doxycycline monohydrate | 17086-28-1 | 5g | $43 | 2024-03-01 | Buy |
| Alfa Aesar | J63805 | Doxycycline monohydrate | 17086-28-1 | 25g | $162 | 2024-03-01 | Buy |
| Usbiological | D9100 | Doxycycline Monohydrate | 17086-28-1 | 10g | $79 | 2021-12-16 | Buy |
| AK Scientific | J95258 | Doxycycline monohydrate | 17086-28-1 | 25g | $95 | 2021-12-16 | Buy |
Doxycycline monohydrate Chemical Properties,Uses,Production
Description
Doxycycline is a broad-spectrum antibiotic synthetically derived from oxytetracycline. It is a semi-synthetic tetracycline. Doxycycline penetrates the bacterial cell and interferes with the protein biosynthesis, stopping the process. Other microorganisms are also sensitive to the antibiotic activity of Doxycycline, such as Mycoplasma, Chlamydia and Ricketsiae. Resistance to antibiotics of the tetracycline family is primarily due to inhibition of transport of the drug into the cell or by increasing antibiotic efflux. The biological mechanism is mainly through plasmid mediation but it may also occur by chromossomal alteration.
Chemical Properties
Doxycycline monohydrate is a Yellow, crystalline powder. It is soluble in ethanol or methanol. It has a high degree of lipid solubility and a low affinity for calcium binding. It is highly stable in normal human serum. It is very slightly soluble in water.
Uses
An antimicrobial. Inhibits angiogenesis and reduces lung metastases by inhibiting matrix metalloproteinasesDoxycycline monohydrate acts as an antibiotic, antimicrobial agent and a matrix metalloproteinase inhibitor. It is also used for the treatment of chloroquine-resistant falciparum malaria. Further, it is used to treat a wide variety of bacterial infections, including those that cause acne. In addition to this, it inhibits the bacterial protein synthesis by preventing the interaction of aminoacyl-tRNA and the bacterial ribosome.
Uses
Doxycycline Monohydrate is used to treat bacterial infections, Lyme disease, chlamydia, Rocky Mountain Spotted Fever, and other susceptible bacterial infections. It is an antibiotic with bacteriostatic properties.
Tetracycline antibacterial.
Application
In yeast cells, doxycycline has been used in doxycycline-inducible system for overexpression of methyltransferase Hmt1 (hnRNP methyltransferase 1).
It has been used in the doxycycline-inducible IFITM (interferon-induced transmembrane) cell lines.
It has also been used as an antimicrobial agent.
Indications
Doxycycline monohydrate (Vibramycin Monohydrate, Monodox, Mondoxyne NL) is a moderately priced drug used to treat many kinds of infections, like dental, skin, respiratory, and urinary tract infections. It also treats acne, Lyme disease, malaria, and certain sexually transmitted infections. This drug is more popular than comparable drugs. It is available in multiple brand and generic versions. Generic doxycycline monohydrate is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower. The lowest GoodRx price for the most common version of doxycycline monohydrate is around $6.02, 80% off the average retail price of $30.66. Compare tetracycline antibiotics.
Definition
ChEBI: The monohydrate form of doxycycline. A semi-synthetic tetracycline antibiotic, it is used to inhibit bacterial protein synthesis and treat non-gonococcal urethritis and cervicitis, exacerbations of bronchitis in patients with chronic obstructive pulmonary isease (COPD), and adult periodontitis.
brand name
Doxychel (Rachelle); Monodox (Oclassen); Oracea (CollaGenex); Vibramycin (Pfizer).
General Description
Doxycycline was synthesized by Pfizer starting with either tetracycline or oxytetracycline in 1958. It shows about fourfold higher antibacterial activity than tetracycline against a variety of pathogens. Doxycycline shows higher oral absorption than tetracycline, and its concentration in tissue is higher and maintained longer. Hyclate is a preparation of doxycycline containing one mole of hydrochloric acid and one-half mole each of ethanol and water per mole of doxycycline.
Biological Activity
Doxycycline is a semisynthetic tetracycline that is active against bacteria, mycoplasma and protozoan parasites. It inhibits the bacterial protein synthesis by inhibiting the interaction of aminoacyl-tRNA and the bacterial ribosome.
Doxycycline monohydrate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21695 | 55 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 | sales@amoychem.com | China | 6387 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| Changzhou Carman Chemical Co., Ltd. | 15061933924 | CHINA | 514 | 58 | |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-81138252 +86-18789408387 | 1057@dideu.com | China | 3783 | 58 |
| SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17367 | 58 |
| Longyan Tianhua Biological Technology Co., Ltd | 0086 18039857276 18039857276 | CHINA | 2783 | 58 |
View Lastest Price from Doxycycline monohydrate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2022-02-25 | Doxycycline
17086-28-1
|
US $4.99 / KG | 1KG | 99% | 100KG | Hong Kong Tiansheng New Material Trading Co., Ltd | |
 |
2022-02-25 | Doxycycline
17086-28-1
|
US $16.00 / KG | 1KG | 99% | 10kg | Hong Kong Tiansheng New Material Trading Co., Ltd | |
 |
2021-07-13 | Doxycycline monohydrate
17086-28-1
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- Doxycycline
17086-28-1
- US $4.99 / KG
- 99%
- Hong Kong Tiansheng New Material Trading Co., Ltd
-
- Doxycycline
17086-28-1
- US $16.00 / KG
- 99%
- Hong Kong Tiansheng New Material Trading Co., Ltd
-
- Doxycycline monohydrate
17086-28-1
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
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