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N-Boc-1,2,5,6-tetrahydropyridine-4-boronic acid pinacol ester

N-Boc-1,2,5,6-tetrahydropyridine-4-boronic acid pinacol ester structure

CAS No.: 286961-14-6

Chemical Name:: N-Boc-1,2,5,6-tetrahydropyridine-4-boronic acid pinacol ester

Synonyms: tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-2H-pyridine-1-carboxylate;N-Boc-1,2,3,6-tetrahydropyridine-4-boronic acid pinacol ester;EOS-60794;3,6-DIHYDR;PyridineC5H5N;N-BOC-1.2.5.6;N-BOC-1.2.5.8-;tert-butyl 4-(4;1-Boc-1,2,5,6-tetrahydrop...;6-tetrahydropyridine-1-carboxylate

CBNumber:: CB3290758

Molecular Formula:: C16H28BNO4

Molecular Weight:: 309.21

MDL Number:: MFCD03840345

MOL File:: 286961-14-6.mol

Last updated:2025-07-24 18:13:45

Product description	Number	Pack Size	Price
N-Boc-1,2,3,6-tetrahydropyridine-4-boronic acid pinacol ester 95%	706531	1g	$142
1-(tert-Butoxycarbonyl)-1,2,3,6-tetrahydro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine >98.0%(GC)(T)	B4051	1g	$92
N-Boc-1,2,5,6-tetrahydropyridine-4-boronic acid pinacol ester	263778	1g	$333
3,6-Dihydro-2H-pyridine-1-N-Boc-4-boronicacid,pinacolester	D453413	100mg	$45
3,6-Dihydro-2H-pyridine-1-N-Boc-4-boronicacid,pinacolester	D453413	250mg	$55
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N-Boc-1,2,5,6-tetrahydropyridine-4-boronic acid pinacol ester Properties

Melting point	114.0 to 118.0 °C
Boiling point	348.0±52.0 °C(Predicted)
Density	1.05±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Chloroform (Sparingly), Dichloromethane (Sparingly), DMSO (Slightly)
form	Solid
pka	-1.21±0.40(Predicted)
color	white to off-white
Water Solubility	Soluble in most organic solvents. Insoluble in water.
InChI	InChI=1S/C16H28BNO4/c1-14(2,3)20-13(19)18-10-8-12(9-11-18)17-21-15(4,5)16(6,7)22-17/h8H,9-11H2,1-7H3
InChIKey	VVDCRJGWILREQH-UHFFFAOYSA-N
SMILES	C1N(C(OC(C)(C)C)=O)CC=C(B2OC(C)(C)C(C)(C)O2)C1
UNSPSC Code	12352103
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P280-P305+P351+P338-P304+P340-P405-P501A

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-37-60

WGK Germany

TSCA

HazardClass

IRRITANT

HS Code

29349990

NFPA 704

	1
0		0

N-Boc-1,2,5,6-tetrahydropyridine-4-boronic acid pinacol ester price More Price(70)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	706531	N-Boc-1,2,3,6-tetrahydropyridine-4-boronic acid pinacol ester 95%	286961-14-6	1g	$142	2025-07-31	Buy
TCI Chemical	B4051	1-(tert-Butoxycarbonyl)-1,2,3,6-tetrahydro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine >98.0%(GC)(T)	286961-14-6	1g	$92	2025-07-31	Buy
Usbiological	263778	N-Boc-1,2,5,6-tetrahydropyridine-4-boronic acid pinacol ester	286961-14-6	1g	$333	2021-12-16	Buy
TRC	D453413	3,6-Dihydro-2H-pyridine-1-N-Boc-4-boronicacid,pinacolester	286961-14-6	100mg	$45	2021-12-16	Buy
TRC	D453413	3,6-Dihydro-2H-pyridine-1-N-Boc-4-boronicacid,pinacolester	286961-14-6	250mg	$55	2021-12-16	Buy

Product number	Packaging	Price	Buy
706531	1g	$142	Buy
B4051	1g	$92	Buy
263778	1g	$333	Buy
D453413	100mg	$45	Buy
D453413	250mg	$55	Buy

N-Boc-1,2,5,6-tetrahydropyridine-4-boronic acid pinacol ester Chemical Properties,Uses,Production

Chemical Properties

off-white powder

Uses

Reagent used for suzuki-Miyaura cross-coupling using palladium phosphine catalyst, palladium-catalyzed ligand-controlled regioselective Suzuki coupling, wrenchnolol derivative optimized for gene activation in cells. Also used in Preparation of several enzymatic inhibitors and receptor ligands, orally active anaplastic lymphoma kinase inhibitors and oxazolecarboxamides as diacylglycerol acyltransferase-1 inhibitors for treatment of obesity and diabetes.

Uses

N-Boc-1,2,5,6-tetrahydropyridine-4-boronic acid pinacol ester is an intermediate for organic synthesis and pharmaceutical research and development, and can be used for suzuki reaction.

Synthesis

1-(tertbutoxycarbonyl)-1,2,3,6-tetrahydropyridin-4-yltrifluoromethanesulfonate

138647-49-1

73183-34-3

1,2,3,6-TETRAHYDROPYRIDINE-4-YL-BORONIC ACID PINACOL ESTER

375853-82-0

The general procedure for the synthesis of 1,2,3,6-tetrahydro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine from tert-butyl 4-(((trifluoromethyl)sulfonyl)oxy)-5,6-dihydropyridine-1(2H)-carboxylate and bipinacolato pinacol ester was carried out as follows: to a dry reaction flask, bis(pinacolato)diboron ( 3.37 g, 13.28 mmol), potassium acetate (KOAc, 3.58 g, 36.46 mmol), [1,1'-bis(diphenylphosphino)ferrocene]palladium(II) dichloride (PDCL2DPPF, 0.27 g, 0.36 mmol), and 1,1'-bis(diphenylphosphino)ferrocene (dppf, 0.2 g, 0.36 mmol) to a dry reaction flask, and the reaction system was subsequently flushed with argon to flush the reaction system. A solution of tert-butyl 4-(((trifluoromethyl)sulfonyl)oxy)-5,6-dihydropyridine-1(2H)-carboxylate (4.00 g, 12.07 mmol) in dioxane (35 mL) was added, and the reaction mixture was stirred at 80 °C overnight. After completion of the reaction, it was cooled to room temperature, diluted with water (50 mL) and extracted with ethyl acetate (EtOAc, 50 mL). The organic layer was separated, washed with saturated saline (50 mL), dried over anhydrous magnesium sulfate (MgSO4) and filtered. The filtrate was concentrated under reduced pressure and the crude product was purified by fast column chromatography (eluent ratio of 9:1 hexane:ethyl acetate) to give the target product as a white solid (4.5 g, 100% yield).

References

[1] Patent: WO2004/58727, 2004, A1. Location in patent: Page 53-54
[2] Patent: WO2014/100501, 2014, A1. Location in patent: Paragraph 00727; 00728
[3] Patent: WO2015/200534, A2. Location in patent: Paragraph 00297; 00586; 00643
[3] Patent: , 2015, . Location in patent: Paragraph 00297; 00586; 00643
[5] Patent: WO2008/88881, 2008, A1. Location in patent: Page/Page column 59-60

N-Boc-1,2,5,6-tetrahydropyridine-4-boronic acid pinacol ester Preparation Products And Raw materials

Raw materials

2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 1-(tertbutoxycarbonyl)-1,2,3,6-tetrahydropyridin-4-yltrifluoromethanesulfonate Bis(pinacolato)diboron tert-butyl 4-broMo-5,6-dihydropyridine-1(2H)-carboxylate

Preparation Products

N-Boc-1,2,5,6-tetrahydropyridine-4-boronic acid pinacol ester Suppliers

Global( 403)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
Jinan Million Pharmaceutical Co., Ltd	0531-68659554 +8613031714605	info@millionpharm.com	China	208	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	13493	58
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1803	55
Hi-Tech Chemistry Corp	0519-86626038	yuhh@hitechem.com	CHINA	810	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21614	55
Shanghai Time Chemicals CO., Ltd.	+86-021-57951555 +8617317452075	jack.li@time-chemicals.com	China	1803	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Zjartschem	+86-571 87238903	jocelynpan@zjarts.com	CHINA	988	58

Supplier	Advantage
ShenZhen Trendseen Biological Technology Co.,Ltd.	58
Jinan Million Pharmaceutical Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Hi-Tech Chemistry Corp	58
Henan Tianfu Chemical Co.,Ltd.	55
Shanghai Time Chemicals CO., Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
Zjartschem	58

View Lastest Price from N-Boc-1,2,5,6-tetrahydropyridine-4-boronic acid pinacol ester manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-12-01	N-Boc-1,2,5,6-tetrahydropyridine-4-boronic acid pinacol ester 286961-14-6	US $1.00 / kg	0.10000000149011612kg	99%	200KG	Jinan Million Pharmaceutical Co., Ltd
2025-04-04	N-Boc-1,2,5,6-tetrahydropyridine-4-boronic acid pinacol ester 286961-14-6	US $0.00-0.00 / KG	1KG	98%	1ton	Henan Aochuang Chemical Co.,Ltd.
2025-03-04	N-Boc-1,2,5,6-tetrahydropyridine-4-boronic acid pinacol ester 286961-14-6	US $0.00-0.00 / kg	1kg	99%min	20 tons	Hangzhou Verychem Science And Technology Co.Ltd

N-Boc-1,2,5,6-tetrahydropyridine-4-boronic acid pinacol ester
286961-14-6
US $1.00 / kg
99%
Jinan Million Pharmaceutical Co., Ltd

N-Boc-1,2,5,6-tetrahydropyridine-4-boronic acid pinacol ester
286961-14-6
US $0.00-0.00 / KG
98%
Henan Aochuang Chemical Co.,Ltd.

N-Boc-1,2,5,6-tetrahydropyridine-4-boronic acid pinacol ester
286961-14-6
US $0.00-0.00 / kg
99%min
Hangzhou Verychem Science And Technology Co.Ltd

N-Boc-1,2,5,6-tetrahydropyridine-4-boronic acid pinacol ester Spectrum

N-Boc-1,2,5,6-tetrahydropyridine-4-boronic acid pinacol ester(286961-14-6)¹HNMR N-Boc-1,2,5,6-tetrahydropyridine-4-boronic acid pinacol ester(286961-14-6)FT-IR

286961-14-6(N-Boc-1,2,5,6-tetrahydropyridine-4-boronic acid pinacol ester)Related Search:

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Tris(trimethylsilyl)phosphate 2,2,4-Trimethyl-1,3-pentanediol monoisobutyrate Diethyl phthalate Pyridine hydrofluoride 1,1'-Carbonyldiimidazole

Dimethyl succinate Dihydromyrcenol tert-butyl 4-(4-amino-2-methoxyphenyl)piperazine-1-carboxylate tert-butyl 4-(4-hydroxybutyl)piperazine-1-carboxylate Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate

N-BOC-1,2,3,6-TETRAHYDROPYRIDINE N-BOC-3-Aminopiperidine N-Boc-4-iodopiperidine

1of4

N-BOC-1,2,5,6-TETRAHYDROPYRIDINE-4-(PINACOLATO)BORONATE (N-TERT-BUTOXYCARBONYL)-1,2,3,6-TETRAHYDROPYRIDINE-4-BORONIC ACID PINACOL ESTER 4-(4,4,5,5-TETRAMETHYL-[1,3,2]-DIOXABOROLAN-2-YL)-3,6-DIHYDRO-2H-PYRIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 3,6-DIHYDRO-2H-PYRIDINE-1-TERT-BUTOXYCARBONYL-4-BORONIC ACID, PINACOL ESTER 1-N-BOC-4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-3,6-DIHYDRO-2H-PYRIDINE 1-N-BOC-4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-3,6-DIHYDRO-2H-PYRIDINE 98+% N-Boc-1,2,5,6-tetrahydropyridine-4-boronic acid pinacol ester tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,6-tetrahydropyridine-1-carboxylate 1-Boc-4-(4,4,5,5-tetraMethyl-[1,3,2]dioxaborolan-2-yl)-3,6-dihydro-2H-pyridine tert-butyl 4-(tetraMethyl-1,3,2-dioxaborolan-2-yl)- 1,2,3,6-tetrahydropyridine-1-carboxylate PyridineC5H5N 3,6-Dihydro-2H-pyridine-1-N-Boc-4-boronic acid pinacol ester 4-(4,4,5,5-TetraMethyl-[1,3,2]dioxaborolan-2-yl)-3,6-dihydro-2H-pyridine-1-carboxylic acid isopropyl ester 3,6-DIHYDR tert-butyl4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-5,6-dihydropyridine-1(2H)-carboxylate N-Boc-1,2,5,6- 3,6-DIHYDRO-2H-PYRIDINE-1-TERT-BUTOXYCARBONYL-4-BORONIC ACID PINACOL ESTER; N-BOC-1,2,5,6-TETRAHYDROPYRIDINE-4-(PINACOLATO)BORONATE tert-Butyl 1,2,3,6-tetrahydro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-1-carboxylate, tert-Butyl 3,6-dihydro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-1-carboxylate tert-butyl 4-(hydroxy((3-hydroxy-2,3-diMethylbutan-2-yl)oxy)boryl)-5,6-dihydropyridine-1(2H)-carboxylate 1-n-boc-3,6-dihydro-2h-pyridine-4-boronic acid pinacol ester (1-tert-Butoxycarbonyl-1,2,3,6-tetrahydropyridin-4-yl)boronic acid pinacol ester (N-tert-Butoxycarbonyl-1,2,3,6-tetrahydropyridin-4-yl)boronic acid pinacol ester (N-tert-Butoxycarbonyl-1,2,5,6-tetrahydropyridin-4-yl)boronic acid pinacol ester N-Boc-1,2,5,6-tetrahydropyridine-4-boronic acid pinacol ester 3,6-Dihydro-2H-pyridine-1-tert-butoxycarbonyl-4-boronic acid pinacol ester [1-Boc-1,2,3,6-tetrahydropyridine-4-yl]boronic acid pinacol ester 4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-3,6-dihydro-2H-pyridine-1-carboxylicacidtert-butylester 1(2H)-Pyridinecarboxylic acid, 3,6-dihydro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, 1,1-dimethylethyl ester tert-butyl5,6-dihydro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-1(2H)-carbo 3,6-Dihydro-2H-pyridine-1-tert-butoxycarbonyl-4-boronic acid (N-Tert-butoxycarbonyl)-1,2,3,6-tetrahydropyridine-4-boronic acid pinacol ester ,97% tert-butyl 5,6-dihydro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-1(2H)-carboxylate 1-N-BOC-4-(4,4,5,5-TETRAMETHYL-2-YL)-3,6-DIHYDRO-2H-PYRIDINE N-(tert-butoxycarbonyl)-3,6-dihydro-2H-pyridine-4-boronic acidpinacol ester, 97% 1,2,3,6-Tetrahydropyridine-4-boronic acid, pinacol ester, N-BOC protected 6-tetrahydropyridine-1-carboxylate tert-butyl 4-(4 3,6-Dihydro-2H-Pyridine-1-Boc -4-Boronic Acid Pinacol Ester tert-butyl 4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,6-tetrahydropyridine-1-carboxylat 1-Boc-1,2,5,6-tetrahydropyridine-4-boronic acid pinacol ester 1-N-Boc-4-(4,4,5,5- tetraMethyl(1,3,2)dioxoborolan-2-yl)-3,6- dihydro-2H-pyridine tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,6-tetrahydropyridine-1-carboxylate, tert-Butyl 3,6-dihydro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-1(2H)-carboxylate 1-Boc-1,2,5,6-tetrahydrop... 1-(tert-Butoxycarbonyl)-1,2,3,6-tetrahydro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine t-Butyl 4-(4,4,5,5,-tetramethyl-1,3,2,-dioxaborolan-2-yl)-5,6-dihydropyridine-1(2H)-carboxylate Pinacol 1-Boc-2,3,6-trihydropyridin-4-ylboronate tert-butyl4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydropyridine-1(2H)-carboxylate [1-Boc-1,2,5,6-tetrahydropyridine-4-yl]boronic acid pinacol ester N-BOC-1.2.5.6 N-BOC-1.2.5.8- 1-(tert-Butoxycarbonyl)-1,2,3,6-tetrahydro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborol-an-2-yl)-5,6-dihydropyridine-1(2H)-carboxyl N-Boc-1,2,5,6-tetrahydropyridine-4-boronic acid picol ester N-Boc-1,2,5,6-tetrahydropyridine-4-boronic acid pinacol este... 1-(tert-Butoxycarbonyl)-1,2,3,6-tetrahydro-4-pyridylboronic Acid Pinacol Ester 1-Boc-1,2,3,6-tetrahydropyridine-4-boronic Acid Pinacol Ester 2-[1-(tert-Butoxycarbonyl)-1,2,3,6-tetrahydro-4-pyridyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane ert-butyl4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-2H-pyridine-1-carboxylate 3,6-Dihydro-2H-pyridine-1-tert-butoxycarbonyl-4-boronic acid pinacol este 1-BOC-1,2,3,6-tetrahydro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) pyridine