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Ketoprofen

Used in Particular Diseases
Ketoprofen
Ketoprofen structure
CAS No.
22071-15-4
Chemical Name:
Ketoprofen
Synonyms
aneol;Dexal;Topre;Iso-K;ORUDIS;Epatec;Fastum;Lertus;ru4733;Toprec
CBNumber:
CB3299418
Molecular Formula:
C16H14O3
Formula Weight:
254.28
MOL File:
22071-15-4.mol

Ketoprofen Properties

Melting point:
93-96°C
Boiling point:
357.5°C (rough estimate)
Density 
1.1565 (rough estimate)
refractive index 
1.5600 (estimate)
storage temp. 
0-6°C
solubility 
Slightly soluble in chloroform and methanol.
form 
solid
pka
pKa 5.94(MeOH/H2O) (Uncertain)
Water Solubility 
209mg/L(room temperature)
Merck 
14,5305
InChIKey
DKYWVDODHFEZIM-UHFFFAOYSA-N
CAS DataBase Reference
22071-15-4(CAS DataBase Reference)
EWG's Food Scores
1
FDA UNII
90Y4QC304K
NCI Dictionary of Cancer Terms
ketoprofen
NIST Chemistry Reference
Ketoprofen(22071-15-4)
EPA Substance Registry System
Benzeneacetic acid, 3-benzoyl-.alpha.-methyl- (22071-15-4)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS06
Signal word  Danger
Hazard statements  H301-H315-H319-H335
Precautionary statements  P280a-P301+P310a-P405-P501a-P261-P301+P310-P305+P351+P338
Hazard Codes  T
Risk Statements  25-36/37/38-23/24/25
Safety Statements  26-45-36/37/39
RIDADR  2811
WGK Germany  3
RTECS  UE7570000
TSCA  Yes
HazardClass  6.1(b)
PackingGroup  III
HS Code  29183000
Toxicity LD50 orally in rats: 101 mg/kg (Ueno)

Ketoprofen price More Price(18)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 34016 Ketoprofen VETRANAL , analytical standard 22071-15-4 100mg-r $61 2019-12-02 Buy
Sigma-Aldrich 1356632 Ketoprofen United States Pharmacopeia (USP) Reference Standard 22071-15-4 200mg $352.8 2019-12-02 Buy
TCI Chemical K0038 Ketoprofen >98.0%(HPLC)(T) 22071-15-4 25g $171 2020-06-24 Buy
TCI Chemical K0038 Ketoprofen >98.0%(HPLC)(T) 22071-15-4 250g $986 2020-06-24 Buy
Alfa Aesar J62702 Ketoprofen 22071-15-4 25g $248 2020-06-24 Buy

Ketoprofen Chemical Properties,Uses,Production

Used in Particular Diseases

Acute Gouty Arthritis:
Dosage and Frequency: 75 mg four times a day

Chemical Properties

White Crystalline Solid

Uses

Natural Vitamin B12. analog

Uses

Ketoprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties.

Uses

Anti-inflammatory; analgesic

Definition

ChEBI: An oxo monocarboxylic acid that consists of propionic acid substituted by a 3-benzoylphenyl group at position 2.

Indications

Ketoprofen (Orudis) is indicated for use in rheumatoid and osteoarthritis, for mild to moderate pain, and in dysmenorrhea. The most frequently reported side effects are GI (dyspepsia, nausea, abdominal pain, diarrhea, constipation, and flatulence) and CNS related (headache, excitation). Edema and increased blood urea nitrogen have also been noted in more than 3% of patients. Ketoprofen can cause fluid retention and increases in plasma creatinine, particularly in the elderly and in patients taking diuretics.

brand name

Actron (Bayer); Orudis (Wyeth); Oruvail (Wyeth).

General Description

Ketoprofen (Orudis, Rhodis) and suprofen (Profenal) areclosely related to fenoprofen in their structures, properties,and indications. Even though ketoprofen has been approvedfor OTC use (Orudis KT, Actron), its GI side effects aresimilar to indomethacin, and therefore its useshould be closely monitored, especially in patients with GIor renal problems.

Contact allergens

Ketoprofen is an anti-inflammatory drug, used both topically and systemically. It is above all a photoaller- gen, responsible for photoallergic or photo-worsened contact dermatitis, with sun-induced, progressive, severe, and durable reactions. Recurrent photosensitiv- ity is possible for many years. Photosensitivities are expected to thiophene-phenylketone derivatives such as tiaprofenic acid and suprofen, to ketoprofen esters such as piketoprofen, and to benzophenone derivatives (see above) such as fenofibrate and benzophenone-3. Concomitant photosensitivities without clinical rel- evance have been observed to fenticlor, tetrachloro- salicylanilide, triclosan, tribromsalan, and bithionol.

Pharmacokinetics

Ketoprofen is rapidly and nearly completely absorbed on oral administration, reaching peak plasma levels within 0.5 to 2 hours. It is highly plasma protein bound (99%) despite a lower acidity (pKa = 5.9) than some other NSAIDs. Wide variation in plasma half-lives has been reported. It is metabolized by glucuronidation of the carboxylic acid, CYP3A4 and CYP2C9 hydroxylation of the benzoyl ring, and reduction of the keto function.

Clinical Use

Ketoprofen, unlike many NSAIDs, inhibits the synthesis of leukotrienes and leukocyte migration into inflamed joints in addition to inhibiting the biosynthesis of prostaglandins. It stabilizes the lysosomal membrane during inflammation, resulting in decreased tissue destruction. Antibradykinin activity also has been observed. Bradykinin is released during inflammation and can activate peripheral pain receptors. In addition to anti-inflammatory activity, ketoprofen also possesses antipyretic and analgetic properties. Although it is less potent than indomethacin as an anti-inflammatory agent and an analgetic, its ability to produce gastric lesions is about the same.

Safety Profile

Poison by ingestion,subcutaneous, intravenous, rectal, and intraperitoneal routes. Human systemic effects by an unspecified route:headache, nausea or vomiting, and degenerative changesin the brain, changes in kidney tubules. An experimentalteratogen.

Veterinary Drugs and Treatments

Ketoprofen is labeled for use in horses for the alleviation of inflammation and pain associated with musculoskeletal disorders. Like flunixin (and other NSAIDs), ketoprofen potentially has many other uses in a variety of species and conditions. There are approved dosage forms for dogs and cats in Europe and Canada. Some consider ketoprofen to be the NSAID of choice for use short-term for analgesia in cats.

Ketoprofen Preparation Products And Raw materials

Raw materials

Preparation Products


Ketoprofen Suppliers

Global( 372)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shanghai Bojing Chemical Co.,Ltd.
+86-21-37122233
+86-21-37127788 Candy@bj-chem.com CHINA 497 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22625 55
Hangzhou FandaChem Co.,Ltd.
0086 158 5814 5714 (Mobile
+86-571-56059825 fandachem@gmail.com CHINA 3269 55
PI & PI BIOTECH INC.
18371201331
020-81716319 Sales@pipitech.com CHINA 3048 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682
02783214688 bruce@xrdchem.cn CHINA 568 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24754 60
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 2678 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30043 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23977 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28231 58

View Lastest Price from Ketoprofen manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2020-04-29 Ketoprofen
22071-15-4
US $1.00-1.00 / KG 1g 99% 50tons Shaanxi Dideu Medichem Co. Ltd
2020-05-07 Ketoprofen
22071-15-4
US $1.00-1.00 / KG 1g 99% 50tons Shaanxi Dideu Medichem Co. Ltd
2019-11-05 ketoprofen
22071-15-4
US $60.00 / KG 10g 99.8% 10tons Hebei shuoxi biotechnology co. LTD

Ketoprofen Spectrum


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