mavatrep
- CAS No.
- 956274-94-5
- Chemical Name:
- mavatrep
- Synonyms
- CS-1660;mavatrep;Mavatrep(JNJ-39439335);JNJ 39439335;JNJ39439335;(trans)-2-(2-{2-[2-(4-trifluoromethylphenyl)vinyl]-1H-benzimidazol-5-yl}phenyl)propan-2-ol;Benzenemethanol, α,α-dimethyl-2-[2-[(1E)-2-[4-(trifluoromethyl)phenyl]ethenyl]-1H-benzimidazol-6-yl]-;JNJ39439335,Inhibitor,capsaicin,JNJ 39439335,TRP Channel,neuropathic pain,calcium ions,Mavatrep,inhibit,Transient receptor potential channels,hTRPV1 channel,HEK293
- CBNumber:
- CB33040790
- Molecular Formula:
- C25H21F3N2O
- Molecular Weight:
- 422.45
- MDL Number:
- MOL File:
- 956274-94-5.mol
- MSDS File:
- SDS
| Boiling point | 612.1±65.0 °C(Predicted) |
|---|---|
| Density | 1.300±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| form | Powder |
| pka | 10.73±0.10(Predicted) |
| FDA UNII | F197218T99 |
mavatrep price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-4591 | Mavatrep 99.85% | 956274-94-5 | 5mg | $420 | 2021-12-16 | Buy |
| ApexBio Technology | B5930 | mavatrep | 956274-94-5 | 5mg | $551 | 2021-12-16 | Buy |
| ChemScene | CS-4591 | Mavatrep 99.85% | 956274-94-5 | 10mg | $600 | 2021-12-16 | Buy |
| ApexBio Technology | B5930 | mavatrep | 956274-94-5 | 10mg | $788 | 2021-12-16 | Buy |
| ChemScene | CS-4591 | Mavatrep 99.85% | 956274-94-5 | 50mg | $1800 | 2021-12-16 | Buy |
mavatrep Chemical Properties,Uses,Production
Biological Activity
mavatrep is a potent and orally bioavailable antagonist of trpv1 with ic50 value of 4.6 nm [1][2].transient receptor potential vanilloid-1 (trpv1) is a thermosensitive and nonselective cation channel, and is a member of the trp channel superfamily. the channel is activated by acidic ph (<6.8), thermal stimuli (>43℃), and endogenous lipidic mediators (anandamide and oxidative metabolites of linoleic acid) [1].mavatrep is a potent and orally bioavailable trpv1 antagonist. in hek293 cells that stably express human or rat trpv1 (rtrpv1) channels, mavatrep (1 μm) inhibited capsaicin-induced ca2+ influx with ic50 values of 4.6 nm and 21 nm. in whole-cell patch clamp electrophysiology assay, mavatrep concentration-dependently inhibited the activation of htrpv1 channels by ph (5.0) and capsaicin (1 μm) with ic50 values of 6.8 and 23 nm, respectively. mavatrep (0.1 μm) also inhibited 74 ± 8.1% heat-evoked currents mediated by htrpv1 [1].in the cfa model of inflammatory of pain, mavatrep (10 mg/kg po) significantly reversed cfa-induced thermal hypersensitivity with ed50 and ed80 values of 1.8 and 7.8 mg/kg, respectively [1].
References
[1]. parsons wh, calvo rr, cheung w, et al. benzo[d]imidazole transient receptor potential vanilloid 1 antagonists for the treatment of pain: discovery of trans-2-(2-{2-[2-(4-trifluoromethyl-phenyl)-vinyl]-1h-benzimidazol-5-yl}-phenyl)-propan-2-ol (mavatrep). j med chem, 2015, 58(9): 3859-3874.
mavatrep Preparation Products And Raw materials
Raw materials
Preparation Products
mavatrep Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Finetech Industry Limited | +86-27-87465837 +8618971612321 | info@finetechnology-ind.com | China | 9651 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7553 | 61 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4863 | 58 |
| Finetech Industry Limited | 027-87465837 19945049750 | sales@finetechnology-ind.com | China | 9636 | 58 |
| HangZhou YuHao Chemical Technology Co., Ltd. | 0571-82693216 | info@yuhaochemical.com | China | 2031 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4121 | 55 |