ChemicalBook >> CAS DataBase List >>Niflumic acid

Niflumic acid

CAS No.
4394-00-7
Chemical Name:
Niflumic acid
Synonyms
ACTOL;UP-83;sc1332;Forenol;DONALGIN;NIFLURIL;Landruma;niflumic;Niflumate;Niflumicaci
CBNumber:
CB3307557
Molecular Formula:
C13H9F3N2O2
Molecular Weight:
282.22
MDL Number:
MFCD00010569
MOL File:
4394-00-7.mol
MSDS File:
SDS
Last updated:2023-06-08 09:03:06

Niflumic acid Properties

Melting point 203-204 °C
Boiling point 378.0±42.0 °C(Predicted)
Density 1.3935 (estimate)
storage temp. 2-8°C
solubility Soluble in ethanol (~50 mg/ml), acetone (50 mg/ml, Clear to Slightly Hazy, Yellow), methanol (~50 mg/ml), DMSO (56 mg/ml at 25°C), and acetonitrile (~50 mg/ml).
pka pKa 2.26 ± 0.08;4.44± 0.03(H2O,t =25±0.1,I=0.01(NaCl))(Approximate)
color Light orange to Yellow to Green
Water Solubility 19mg/L(room temperature)
Sensitive Light Sensitive
Merck 14,6531
Stability Stable, but may discolour in light. Incompatible with strong oxidizing agents. Hygroscopic.
InChIKey JZFPYUNJRRFVQU-UHFFFAOYSA-N
EWG's Food Scores 1
FDA UNII 4U5MP5IUD8
ATC code M01AX02,M02AA17
NIST Chemistry Reference Niflumic acid(4394-00-7)
EPA Substance Registry System 3-Pyridinecarboxylic acid, 2-[[3-(trifluoromethyl)phenyl]amino]- (4394-00-7)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H301-H413
Precautionary statements  P264-P270-P273-P301+P310-P405-P501
Hazard Codes  Xn
Risk Statements  20/21/22-36/37/38
Safety Statements  26-36-36/37/39
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  QT2999100
HazardClass  6.1
PackingGroup 
HS Code  29333999
Toxicity LD50 in rats (mg/kg): 370 orally; 155 i.p. (Sorenson)
NFPA 704
0
3 0

Niflumic acid price More Price(34)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich N0630 Niflumic acid 4394-00-7 10g $71.5 2024-03-01 Buy
Sigma-Aldrich N0630 Niflumic acid 4394-00-7 25g $160 2024-03-01 Buy
TCI Chemical T2353 2-(3-Trifluoromethylanilino)nicotinic Acid >98.0%(HPLC)(T) 4394-00-7 25g $120 2024-03-01 Buy
Alfa Aesar J60489 Niflumic acid, 99+% 4394-00-7 5g $47.65 2024-03-01 Buy
Alfa Aesar J60489 Niflumic acid, 99+% 4394-00-7 10g $81.9 2024-03-01 Buy
Product number Packaging Price Buy
N0630 10g $71.5 Buy
N0630 25g $160 Buy
T2353 25g $120 Buy
J60489 5g $47.65 Buy
J60489 10g $81.9 Buy

Niflumic acid Chemical Properties,Uses,Production

Chemical Properties

Crystalline Solid

Originator

Nifluril,U.P.S.A.,France,1968

Uses

analgesic, antiinflammatory

Uses

Anti-inflammatory. Selective cyclooxygenase-2 (COX-2) inhibitor

Uses

Niflumic acid is used for the exact same indications as the drugs described above. Synonyms for this drug are actol, flunir, nifluril, and others.

Definition

ChEBI: Niflumic acid is an aromatic carboxylic acid and a member of pyridines.

Manufacturing Process

Niflumic acid is prepared as follows: Nicotinic acid, m-trifluoromethylaniline, and potassium iodide are intimately mixed and heated on an oil bath at 140°C. The mixture melts to give a dark red liquid. The temperature of the oil bath is allowed to fall to 100°C and is maintained at this temperature for an hour and a half. The mixture puffs up and forms a yellow crystalline mass. After cooling to ordinary temperature, this mass is ground up in a mortar and extracted several times with small volumes of ether to remove excess mtrifluoromethylaniline. The residue is then washed twice with 10 ml of distilled water to remove m-trifluoromethylaniline hydrochloride and potassium iodide, and finally twice with 10 ml of 95% alcohol to remove colored resinous contaminants. After drying at 100°C, 2-(m-trifluoromethylanilino)nicotinic acid is obtained as pale yellow needles (from 70% ethanol) melting at 204°C (Kofler block).

Therapeutic Function

Antiinflammatory

Trade name

Actol (Mayrhofer, Austria; Upsamedica, Spain), Donalgin (Gedeon Richter, Hungary), Livornex (Genepharm, Greece), Ni- flam (Upsamedica, Italy), Nifluril (UPSA, France; Upsamedica, Belgium, Switzerland, Portugal).

Biochem/physiol Actions

Niflumic acid (NFA), a γ-aminobutyric acid type A receptor (GABAARs) antagonist is a non-steroidal anti-inflammatory drug (NSAID) and it belongs to the fenamate class. It is also a blocker of chloride ion channel and a calcium-activated chloride channel (CaCC) inhibitor. NFA possesses anti-inflammatory property and is useful in treating rheumatic disorders. It is also an inhibitor of N-methyl-D-aspartate receptor and glycine receptor. NFA also inhibits enzymes associated with the prostaglandins synthesis.

Side effects

Niflumic acid has been used effectively to treat rheumatoid arthritis, psoriatic arthritis, and hypertrophic osteoarthritis of the hip and knee. Gastric complications are the chief adverse effects of this drug.

Synthesis

Niflumic acid, 2-3-(trifluoromethyl)anilino nicotinic acid (3.2.21), is synthesized either by the reaction of 2-chloronicotinic acid with 3-trifluoromethylaniline [84¨C86], or 2-aminonicotinic acid with 1-bromo-3-trifluoromethylbenzene [87].

Synthesis_4394-00-7

Niflumic acid Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 261)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21700 55
career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29914 58
Xiamen AmoyChem Co., Ltd
+86-592-6051114 +8618959220845 sales@amoychem.com China 6387 58
Shandong chuangyingchemical Co., Ltd.
18853181302 sale@chuangyingchem.com CHINA 5909 58
Chongqing Chemdad Co., Ltd
+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
Alchem Pharmtech,Inc.
8485655694 sales@alchempharmtech.com United States 63711 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427 sales@conier.com China 47465 58
Shaanxi Dideu Medichem Co. Ltd
+86-29-87569265 +86-18612256290 1056@dideu.com China 3959 58
SIMAGCHEM CORP
+86-13806087780 sale@simagchem.com China 17368 58

View Lastest Price from Niflumic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Niflumic Acid  pictures 2023-03-06 Niflumic Acid
4394-00-7
US $10.00 / KG 1KG 99.9% 100000kg Hebei Guanlang Biotechnology Co,.LTD
Niflumic acid pictures 2021-07-20 Niflumic acid
4394-00-7
US $1.00-1.00 / KG 1g 99% 50tons Shaanxi Dideu Medichem Co. Ltd
Niflumic acid pictures 2021-07-20 Niflumic acid
4394-00-7
US $1.00-1.00 / KG 1g 99% 50tons Shaanxi Dideu Medichem Co. Ltd
  • Niflumic Acid  pictures
  • Niflumic Acid
    4394-00-7
  • US $10.00 / KG
  • 99.9%
  • Hebei Guanlang Biotechnology Co,.LTD
  • Niflumic acid pictures
  • Niflumic acid
    4394-00-7
  • US $1.00-1.00 / KG
  • 99%
  • Shaanxi Dideu Medichem Co. Ltd
  • Niflumic acid pictures
  • Niflumic acid
    4394-00-7
  • US $1.00-1.00 / KG
  • 99%
  • Shaanxi Dideu Medichem Co. Ltd
2-[3-(Trifluoromethyl)anilino]nicotinic acid, 2-(α,α,α-Trifluoro-m-toluidino)nicotinic acid Niflumic acid,99% LABOTEST-BB LT00451962 DONALGIN 2-(ALPHA,ALPHA,ALPHA-TRIFLUORO-M-TOLUIDINO)NICOTINIC ACID 2-(3-TRIFLUOROMETHYLANILINO)NICOTINIC ACID 2-[(3-TRIFLUOROMETHYL)PHENYL]AMINO]-3-PYRIDINECARBOXYLIC ACID 2-[(3-TRIFLUOROMETHYLPHENYL)AMINO]NICOTINIC ACID ACTOL TIMTEC-BB SBB001146 NIFLUMIC ACID NIFLURIL TOSLAB 796450 UP-83 3-Pyridinecarboxylic acid, 2-[[3-(trifluoromethyl)phenyl]amino]- Acide niflumique acideniflumique Acido niflumico acidoniflumico Actol, analgesic aza-2dimethyl-2’,3’(tetrazolyl-5)-6diphenylamino Forenol Landruma Nicotinic acid, 2-(alpha,alpha,alpha-trifluoro-m-toluidino)- Niflumate niflumic Nifluminic acid sc1332 Niflumic Acid:2-[(3-trifluoromethyl) phenyl] amino-3-pyridine-carboxylic acid 2-(alpha,alpha,alpha-trifluoro-m-toluidino)-nicotinicaci Nifumic Acid ACIDUM NIFLUMICUM 2-(α,α,α-trifluoro-m-toluidino)nicotinic acid Nicotinic acid Solution, 100ppm Niflumic acid solution,100ppm ACIDUMNIFLUMICUM(NIFLUMICACID) 2-[(3-Trifluoromethylphenyl)amino]nicotinic Acid Niflumic Acid Acidum Nifumicum Niflumic acid CRS Niflumic acid USP/EP/BP 2-3-(Trifluoromethyl)(phenylamino)pyridin-3-carboxylic acid Niflumicaci 4394-00-7 4934-00-7 C13H9F3N2O2 C13H8F3N2O2 Selective cyclooxygenase-2 (COX-2) inhibitor. Cell Signaling Enzymes Application Index Biochemicals and Reagents BioChemical Cyclooxygenase Inhibitors Cyclooxygenase (COX) Enzymes Enzymes, Inhibitors, and Substrates Aromatics Inhibitors Intermediates & Fine Chemicals Pharmaceuticals