Flomoxef Impurity 5
- CAS No.
- 134237-56-2
- Chemical Name:
- Flomoxef Impurity 5
- Synonyms
- Flomoxef Nucleus;Flomoxef sodium Impurity 5;(6R,7R)-benzhydryl (7-(2-difluoromethylthio)acetamido)-3-(chloromethyl)-7-methoxy-8-oxo-5-oxa-1-aza-bicyclo[4,2,0]oct-2-ene-2-carboxylate;5-Oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-(chloromethyl)-7-[[[(difluoromethyl)thio]acetyl]amino]-7-methoxy-8-oxo-, diphenylmethyl ester, (6R-cis)- (9CI)
- CBNumber:
- CB33129600
- Molecular Formula:
- C25H23ClF2N2O6S
- Molecular Weight:
- 552.97
- MDL Number:
- MOL File:
- 134237-56-2.mol
Flomoxef Impurity 5 Chemical Properties,Uses,Production
Uses
(6R,7R)-benzhydryl (7-(2-difluoromethylthio)acetamido)-3-(chloromethyl)-7-methoxy-8-oxo-5-oxa-1-aza-bicyclo[4,2,0]oct- 2-ene-2-carboxylate is an impurity intermediate mainly used in laboratory R&D and pharmaceutical R&D.
Synthesis
451 mL ofdichloromethane, 2- (difluoro-methylthio) acetic acid 49.6 g, 144.8 mL pyridine was added to reactorand cooled to -40 ° C. (6R, 7R)-benzhydryl-7-amino-3-(chloromethyl)-7-methoxy-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylatein dichloromethane 1080 mL was added to the reactor and temperature wasmaintained at -25 ° C. After the reactionsolution was cooled below -45 ° C, 42 mL of phosphorous oxychloride in 180.4 mLdichloromethane was added at -15°C and stirred for 30 minutes. After checking completion of the reaction1262.8 ml of purified water, 4.59 ml of 35% hydrochloric acid, 2.7 ml of 50%tetrabutylammonium bromide was added dropwise at 0°C, which in turn stirred for10 minutes. Then, 1262.8 ml of methanol was added at 0°C and stirred for 10 minutes. then separating the layer. 902 mL ethanol added to the filtrate and then stirred for 2 hours at -10 and washed with 360.8 mL of ethanol, and a white or slightly yellow horse crystal component of the vacuum-dried for 10 hours at 40 was added (6R,7R)-benzhydryl (7-(2-difluoromethylthio)acetamido)-3-(chloromethyl)-7-methoxy-8-oxo-5-oxa-1-aza-bicyclo[4,2,0]oct-2-ene-2-carboxylate (146.7g, 76%).
Flomoxef Impurity 5 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing Finetech Chemical Co., Ltd. | 025-85710122 17714198479 | sales@fine-chemtech.com | CHINA | 885 | 55 |
| Pharmyao， All for life--- A Specific Trading Platform For Reference Standard Material | +86-020-81716320 +8613602409664 | sales@pharmyao.com | China | 173 | 58 |
| Changsha Chemoway Imp and Exp Co.,Ltd | +86-18942506900 | lilyqu@chemoway.com | CHINA | 233 | 58 |
| China National Standard Pharmaceutical Corporation Limited | +8615391658522 | overseasales@yongstandards.com | China | 11927 | 58 |
| Guangzhou PI PI Biotech Inc | +86-020-81716320 +86-13602409664 | Sales@pipitech.com | China | 3635 | 55 |
| ChemStrong Scientific Co.,Ltd | 0755-66853366 13670046396 | sales@chem-strong.com | China | 17982 | 56 |
| PI & PI BIOTECH INC. | 020-81716320 17788709170 | Sales@pipitech.com | China | 2649 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 | sales@rrkchem.com | China | 55717 | 58 |
| Jinan blalong chemical co. LTD | 2710913286@.com | 1513643261@qq.com | China | 14253 | 58 |
| Cato Research Chemicals Inc. | 020-81215950 4000-868-328 | customer@uwalab.com | United States | 10413 | 58 |
View Lastest Price from Flomoxef Impurity 5 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-10 | Flomoxef Intermidate F3
134237-56-2
|
US $0.00-0.00 / mg | 10mg | 90%+ | 10g | Guangzhou PI PI BIOTECH INC |
-
- Flomoxef Intermidate F3
134237-56-2
- US $0.00-0.00 / mg
- 90%+
- Guangzhou PI PI BIOTECH INC