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Zolmitriptan

Zolmitriptan
Zolmitriptan structure
CAS No.
139264-17-8
Chemical Name:
Zolmitriptan
Synonyms
Zomi;Zomig;311c90;bw311c90;Zolmitrptan;zolmitripan;Zolmitriptan;ZOLMITRIPTANE;ZOLIMITRIPTAN;ZolMitriptan API
CBNumber:
CB3313219
Molecular Formula:
C16H21N3O2
Formula Weight:
287.35684
MOL File:
139264-17-8.mol

Zolmitriptan Properties

Melting point:
136-141°C
alpha 
D22 -5.79° (c = 0.5 in methanol)
storage temp. 
Refrigerator
solubility 
Soluble in DMSO at 5mg/ml
pka
9.64(at 25℃)
form 
powder
color 
white to beige
optical activity
[α]/D -3 to -8°, c = 1 in methanol
λmax
225nm(lit.)
Merck 
14,10189
InChIKey
ULSDMUVEXKOYBU-ZDUSSCGKSA-N
CAS DataBase Reference
139264-17-8(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xi,Xn
Risk Statements  36/37/38-22
Safety Statements  26-36
WGK Germany  3
RTECS  RQ2707000
HS Code  29349990
Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P501 Dispose of contents/container to..…

Zolmitriptan price More Price(11)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML0248 Zolmitriptan ≥98% (HPLC) 139264-17-8 10mg $82.9 2018-11-20 Buy
Sigma-Aldrich 1727009 Zolmitriptan United States Pharmacopeia (USP) Reference Standard 139264-17-8 200mg $352.8 2018-11-13 Buy
TCI Chemical Z0024 Zolmitriptan >98.0%(HPLC)(T) 139264-17-8 1g $255 2018-11-22 Buy
TCI Chemical Z0024 Zolmitriptan >98.0%(HPLC)(T) 139264-17-8 200mg $72 2018-11-22 Buy
Alfa Aesar J60616 Zolmitriptan 139264-17-8 100mg $115 2018-11-13 Buy

Zolmitriptan Chemical Properties,Uses,Production

Description

Zolmitriptan is a selective serotonin receptor agonist of the 1B and 1D subtypes. It is mainly used in the acute treatment of migraine attacks with or without aura and cluster headaches. Zolmitriptan takes effect through binding to human 5-HT1Band 5-HT1Dreceptors, leading to cranial blood vessel constriction and the release of sensory neuropeptides through nerve endings in the trigeminal system. 

Chemical Properties

White Crystalline Powder

Uses

A Serotonin 5HTID-receptor agonist

Uses

adrenergic agonist, nasal decongestant

brand name

Zomig (AstraZeneca); Zomig (IPR).

General Description

Zolmitriptan, the second triptan marketed (approved in1997), has a much better bioavailability (40%–48%) thansumatriptan. It is rapidly absorbed after oral or nasal sprayadministration. It also has an orally disintegrating tablet formulation(Zomig ZMT), which can be taken without water.Zolmitriptan undergoes rapid N-demethylation via CYP1A2to a more potent, active metabolite, N-desmethylzolmitriptan,which is 2 to 6 times more potent than the parentdrug. This active metabolite was detected 5 minutesafter dosing and accounts for about two thirds of the plasmaconcentration of the administered dose of the parent drug.284Thus, it is reasonable to assume that the therapeutic effectsand especially the CNS side effects of zolmitriptan must bein part attributed to the plasma levels of this active metabolite,at least until it is further degraded by hepatic MAO-Ato its inactive indole acetic acid derivatives.

References

https://www.drugbank.ca/drugs/DB00315
Rothner, A. D., et al. "Zolmitriptan oral tablet in migraine treatment: high placebo responses in adolescents." Headache the Journal of Head & Face Pain 46.1(2006):101.
Hedlund, C, et al. "Zolmitriptan nasal spray in the acute treatment of cluster headache: a meta-analysis of two studies. " Neurology49.9(2009):1315–1323.

Zolmitriptan Preparation Products And Raw materials

Raw materials

Preparation Products


Zolmitriptan Suppliers

Global( 283)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Nanjing Gold Pharmaceutical Technology Co. Ltd.
025-84209270 15906146951
025-84209270 wgp@nanjing-pharmaceutical.com CHINA 117 55
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 E-mail:sales03@shyrchem.com
+86-21-34979012 sales03@shyrchem.com CHINA 663 60
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 19997 58
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 22043 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20786 55
Shanghai Time Chemicals CO., Ltd.
+86-021-57951555
+86-021-57951555 jack.li@time-chemicals.com CHINA 1374 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32651 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070;product@chemlin.com.cn
product@chemlin.com.cn CHINA 3015 60
Jinan Jianfeng Chemical Co., Ltd
15562555968
info@pharmachemm.com CHINA 617 58
Jinan Shengqi pharmaceutical Co,Ltd
86+15552594168
christine@shengqipharm.com CHINA 339 58

View Lastest Price from Zolmitriptan manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-07-23 Zolmitriptan
139264-17-8
US $4500.00 / KG 1KG 99% 500KG career henan chemical co

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