6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid
- CAS No.
- 1467057-23-3
- Chemical Name:
- 6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid
- Synonyms
- CS-2760;EOS-61684;PF 6409577;PF-06409577;PF 06409577;PF06409577;PF-06409577 >=98% (HPLC);PF-06409577;PF 06409577;PF06409577;6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid;1H-Indole-3-carboxylic acid, 6-chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-;Inhibitor,AMP-activated protein kinase,PF-06409577,AMPK,PF06409577,inhibit
- CBNumber:
- CB33142869
- Molecular Formula:
- C19H16ClNO3
- Molecular Weight:
- 341.79
- MDL Number:
- MFCD29917835
- MOL File:
- 1467057-23-3.mol
- MSDS File:
- SDS
| Boiling point | 610.9±55.0 °C(Predicted) |
|---|---|
| Density | 1.468±0.06 g/cm3(Predicted) |
| storage temp. | room temp |
| solubility | DMSO: soluble |
| pka | 3.60±0.30(Predicted) |
| form | powder |
| color | white to beige |
| FDA UNII | A89WAM8FBH |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P305+P351+P338 | |||||||||
| NFPA 704 |
|
6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PZ0319 | PF-06409577 ≥98% (HPLC) | 1467057-23-3 | 5MG | $105 | 2023-06-20 | Buy |
| Sigma-Aldrich | PZ0319 | PF-06409577 ≥98% (HPLC) | 1467057-23-3 | 25MG | $424 | 2023-06-20 | Buy |
| Cayman Chemical | 27366 | PF-06409577 | 1467057-23-3 | 5mg | $100 | 2024-03-01 | Buy |
| Cayman Chemical | 27366 | PF-06409577 | 1467057-23-3 | 25mg | $343 | 2024-03-01 | Buy |
| Cayman Chemical | 27366 | PF-06409577 | 1467057-23-3 | 1mg | $32 | 2024-03-01 | Buy |
6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid Chemical Properties,Uses,Production
Description
PF-06409577 is an activator of AMP-activated protein kinase (AMPK) heterotrimers (Kd = 9 nM for α1β1γ1). In vitro, it selectively activates β1-containing AMPK isoforms (EC50s = 2.18-7.03 nM) over β2-containing isoforms (EC50s = ≥10 μM). PF-06409577 has an EC50 value of 7 nM in an activation/protection TR-FRET assay using α1β1γ1 AMPK. In vivo, PF-06409577 (≥10 mg/kg) increases phosphorylation of AMPK in rat kidney. It decreases urinary albumin levels in a ZSF1 obese rat model of diabetes, metabolic syndrome, and renal disease when administered at a dose of 100 mg/kg.
Uses
PF-06409577 has been used to determine its potential as a therapeutic agent for diabetic nephropathy.
General Description
PF-06409577 is a 6-chloro-indole derivative obtained from 5-bromo-6-chloro-indole.
Biochem/physiol Actions
PF-06409577 preserves retinal pigment epithelium cells from UV radiation by activating AMPK (AMP-activated protein kinase) signaling. This orally bioavailable and possesses pharmacokinetic properties. PF-06409577 blocks de novo lipid and cholesterol synthesis pathways that shows a decrease in hepatic lipids and mRNA expression of markers of hepatic fibrosis.
storage
Store at RT
6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 11013 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Sichuan Biosynce Pharmatech Co., Ltd. | +8619950309693 | diane@biosynce.com | China | 4874 | 58 |