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Plecanatide

CAS No.
467426-54-6
Chemical Name:
Plecanatide
Synonyms
Trulance;ATCH(1-39);Pukanatide;Plecanatide;Prikanatide;Plecanatide impurity;Plecanatide USP/EP/BP;Plecanatide Impurtiy;ASN-ASP-GLU-CYS-GLU-LEU-CYS-VAL-ASN-VAL-ALA-CYS-THR-GLY-CYS-LEU(DISULFIDE BOND CYS1&CYS3,CYS2&CYS4);L-Leucine, L-asparaginyl-L-α-aspartyl-L-α-glutamyl-L-cysteinyl-L-α-glutamyl-L-leucyl-L-cysteinyl-L-valyl-L-asparaginyl-L-valyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-, cyclic (4→12),(7→15)-bis(disulfide)
CBNumber:
CB33164713
Molecular Formula:
C65H104N18O26S4
Molecular Weight:
1681.89
MDL Number:
MFCD33029246
MOL File:
467426-54-6.mol
Last updated:2023-11-15 17:17:25

Plecanatide Properties

Boiling point 2120.0±65.0 °C(Predicted)
Density 1.47±0.1 g/cm3(Predicted)
pka 3.61±0.21(Predicted)
InChIKey NSPHQWLKCGGCQR-DLJDZFDSSA-N
FDA UNII 7IK8Z952OK
ATC code A06AX07

Plecanatide Chemical Properties,Uses,Production

Uses

Plecanatide is used in the treatment of chronic idiopathic constipation and irritable bowel syndrome with constipation. It works as a laxative by drawing water in to the gastrointestinal tract thereby softening stool and encouraging its natural passage.

Enzyme inhibitor

This uroguanylin analogue (FW = 1681.90 g/mol; CAS 467426-54-6), also known by the codename SP-304, binds to and activates guanylate cyclase-C (GC-C) receptors (EC50 ≈ 0.3 μM) expressed on the epithelial cells lining turn sequentially activates protein kinase G-II and the chloride channel known as the Cystic Fibrosis Transmembrane-conductance Regulator (CFTR) to regulate ion and fluid transport, to promote epithelial cell homeostasis, and to maintain barrier function in the GI mucosa. Plecanatide is a hexadecapeptide that is structurally identical to uroguanylin, except for an glutamate substitution at position-3. Oral treatment with plecanatide at a dose range between 0.05-2.5 mg/kg per day is as effective as once-daily treatment with 5-amino salicylic acid (100 mg/kg) or sulfasalazine (80 mg/kg). Amelioration of colitis by the treatment with plecanatide or dolcanatide was not dose-dependent, most likely due to saturation of available GC-C receptors.

Plecanatide Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 157)Suppliers
Supplier Tel Email Country ProdList Advantage
AFINE CHEMICALS LIMITED
0571-85134551 info@afinechem.com CHINA 15377 58
Apextide Co Ltd
+undefined15700198315 senjie.hou@sinopep.com China 71 58
Shanghai Chinqesen Biotechnology Co., Ltd.
+86-16628886292 +86-19521323435 sales2@qschem-pharma.com China 253 58
Shanghai Yunao International Trade Co., Ltd
+8617621705551 asdf@shanghaihg.cn China 265 58
Zibo Hangyu Biotechnology Development Co., Ltd
+86-0533-2185556 +8617865335152 Mandy@hangyubiotech.com China 11001 58
Nantong Guangyuan Chemicl Co,Ltd
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Alpha Biopharmaceuticals Co., Ltd
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Capot Chemical Co.,Ltd.
571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Beijing Cooperate Pharmaceutical Co.,Ltd
010-60279497 sales01@cooperate-pharm.com CHINA 1811 55
Hangzhou FandaChem Co.,Ltd.
008657128800458; +8615858145714 fandachem@gmail.com China 9354 55

View Lastest Price from Plecanatide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Plecanatide pictures 2024-03-08 Plecanatide
467426-54-6
US $10.00 / kg 1kg 99% 1000kg Nantong Guangyuan Chemicl Co,Ltd
Plecanatide pictures 2024-01-02 Plecanatide
467426-54-6
US $75.00-750.00 / kg 10kg 0.99 20tons Zibo Hangyu Biotechnology Development Co., Ltd
Plecanatide pictures 2023-12-11 Plecanatide
467426-54-6
US $30.00-20.00 / kg 1kg 99% 2000000 Shanghai Chinqesen Biotechnology Co., Ltd.
  • Plecanatide pictures
  • Plecanatide
    467426-54-6
  • US $10.00 / kg
  • 99%
  • Nantong Guangyuan Chemicl Co,Ltd
  • Plecanatide pictures
  • Plecanatide
    467426-54-6
  • US $75.00-750.00 / kg
  • 0.99
  • Zibo Hangyu Biotechnology Development Co., Ltd
  • Plecanatide pictures
  • Plecanatide
    467426-54-6
  • US $30.00-20.00 / kg
  • 99%
  • Shanghai Chinqesen Biotechnology Co., Ltd.
Plecanatide ASN-ASP-GLU-CYS-GLU-LEU-CYS-VAL-ASN-VAL-ALA-CYS-THR-GLY-CYS-LEU(DISULFIDE BOND CYS1&CYS3,CYS2&CYS4) Plecanatide Impurtiy L-Leucine, L-asparaginyl-L-α-aspartyl-L-α-glutamyl-L-cysteinyl-L-α-glutamyl-L-leucyl-L-cysteinyl-L-valyl-L-asparaginyl-L-valyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-, cyclic (4→12),(7→15)-bis(disulfide) Plecanatide impurity Plecanatide USP/EP/BP Prikanatide ATCH(1-39) Trulance (4S)-4-[(2S)-2-[(2S)-2-amino-3-carbamoylpropanamido]-3-carboxypropanamido]-4-{[(1R,4S,7S,10S,13S,16R,19S,22S,25R,32S,38R)-10-(carbamoylmethyl)-38-{[(1S)-1-carboxy-3-methylbutyl]carbamoyl}-22-(2-carboxyethyl)-32-[(1R)-1-hydroxyethyl]-4-methyl-19-(2-methylpropyl)-3,6,9,12,15,18,21,24,30,33,36-undecaoxo-7,13-bis(propan-2-yl)-27,28,40,41-tetrathia-2,5,8,11,14,17,20,23,31,34,37-undecaazabicyclo[14.13.13]dotetracontan-25-yl]carbamoyl}butanoic acid Pukanatide 467426-54-6 C65H104N18O26S4