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Plecanatide

Plecanatide
Plecanatide structure
CAS No.
467426-54-6
Chemical Name:
Plecanatide
Synonyms
Plecanatide;Prikanatide;Plecanatide impurity;Plecanatide USP/EP/BP;Plecanatide fandachem;Plecanatide Impurtiy;ASN-ASP-GLU-CYS-GLU-LEU-CYS-VAL-ASN-VAL-ALA-CYS-THR-GLY-CYS-LEU(DISULFIDE BOND CYS1&CYS3,CYS2&CYS4);L-Leucine, L-asparaginyl-L-α-aspartyl-L-α-glutamyl-L-cysteinyl-L-α-glutamyl-L-leucyl-L-cysteinyl-L-valyl-L-asparaginyl-L-valyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-, cyclic (4→12),(7→15)-bis(disulfide)
CBNumber:
CB33164713
Molecular Formula:
C65H104N18O26S4
Formula Weight:
1681.89
MOL File:
467426-54-6.mol

Plecanatide Properties

Boiling point:
2120.0±65.0 °C(Predicted)
Density 
1.47±0.1 g/cm3(Predicted)
pka
3.61±0.21(Predicted)
FDA UNII
7IK8Z952OK
ATC code
A06AX07

Plecanatide Chemical Properties,Uses,Production

Enzyme inhibitor

This uroguanylin analogue (FW = 1681.90 g/mol; CAS 467426-54-6), also known by the codename SP-304, binds to and activates guanylate cyclase-C (GC-C) receptors (EC50 ≈ 0.3 μM) expressed on the epithelial cells lining turn sequentially activates protein kinase G-II and the chloride channel known as the Cystic Fibrosis Transmembrane-conductance Regulator (CFTR) to regulate ion and fluid transport, to promote epithelial cell homeostasis, and to maintain barrier function in the GI mucosa. Plecanatide is a hexadecapeptide that is structurally identical to uroguanylin, except for an glutamate substitution at position-3. Oral treatment with plecanatide at a dose range between 0.05-2.5 mg/kg per day is as effective as once-daily treatment with 5-amino salicylic acid (100 mg/kg) or sulfasalazine (80 mg/kg). Amelioration of colitis by the treatment with plecanatide or dolcanatide was not dose-dependent, most likely due to saturation of available GC-C receptors.

Plecanatide Preparation Products And Raw materials

Raw materials

Preparation Products


Plecanatide Suppliers

Global( 78)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shochem(Shanghai) Co.,Ltd
86-21-50800795
info@shochem.com CHINA 289 58
AFINE CHEMICALS LIMITED
008657185134551
008657185134895 info@afinechem.com CHINA 15559 58
Hangzhou Go Top Peptide Biotech
0571-88211921
sales1@gotopbio.com CHINA 2610 58
Alpha Biopharmaceuticals Co., Ltd
0086-411-39042497
0086-411-39042693 sales@alphabiopharm.com China 896 58
Beijing Cooperate Pharmaceutical Co.,Ltd
010-60279497
010-60279497 sales01@cooperate-pharm.com CHINA 1817 55
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 8909 55
Rixing Chemical CO.,LTD
13237129059
- info@rixingchemi.com CHINA 229 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29954 58
BOC Sciences
1-631-485-4226
1-631-614-7828 inquiry@bocsci.com United States 19752 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 37282 58

View Lastest Price from Plecanatide manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-11-08 Plecanatide
US $10.00 / KG 1KG 99% 5000kg Wuhan wingroup Pharmaceutical Co., Ltd
2021-09-16 Plecanatide
467426-54-6
US $0.00-0.00 / g 1g 99% 100KG Hangzhou Huarong Pharm Co., Ltd.
2021-08-04 Plecanatide USP/EP/BP
467426-54-6
US $1.10 / g 1g 0.999 100 Tons min Dideu Industries Group Limited

467426-54-6(Plecanatide)Related Search:


  • Plecanatide
  • ASN-ASP-GLU-CYS-GLU-LEU-CYS-VAL-ASN-VAL-ALA-CYS-THR-GLY-CYS-LEU(DISULFIDE BOND CYS1&CYS3,CYS2&CYS4)
  • Plecanatide Impurtiy
  • L-Leucine, L-asparaginyl-L-α-aspartyl-L-α-glutamyl-L-cysteinyl-L-α-glutamyl-L-leucyl-L-cysteinyl-L-valyl-L-asparaginyl-L-valyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-, cyclic (4→12),(7→15)-bis(disulfide)
  • Plecanatide fandachem
  • Plecanatide impurity
  • Plecanatide USP/EP/BP
  • Prikanatide
  • 467426-54-6
  • C65H104N18O26S4
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