ChemicalBook >> CAS DataBase List >>ML 18
ML 18
- CAS No.
- 1422269-30-4
- Chemical Name:
- ML 18
- Synonyms
- ML 18;ML18, >98%;BRS-3 antagonist;ML18;ML-18;ML 18;BRS-3 ANTAGONIST;1422269-30-4;Bombesin Receptor,ML-18,ML 18,inhibit,Inhibitor,ML18;(S)-3-(1H-Indol-3-yl)-N-((1-(4-methoxyphenyl)cyclohexyl)methyl)-2-(3-(4-nitrophenyl)ureido)propanamide;(2S)-3-(1H-INDOL-3-YL)-N-{[1-(4-METHOXYPHENYL)CYCLOHEXYL]METHYL}-2-{[(4-NITROPHENYL)CARBAMOYL]AMINO}PROPANAMIDE
- CBNumber:
- CB33170389
- Molecular Formula:
- C32H35N5O5
- Molecular Weight:
- 569.66
- MDL Number:
- MOL File:
- 1422269-30-4.mol
Last updated:2023-06-08 09:02:58
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| NFPA 704 |
|
ML 18 price More Price(18)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 27319 | ML-18 | 1422269-30-4 | 500μg | $35 | 2024-03-01 | Buy |
| Cayman Chemical | 27319 | ML-18 | 1422269-30-4 | 1mg | $67 | 2024-03-01 | Buy |
| Cayman Chemical | 27319 | ML-18 | 1422269-30-4 | 5mg | $193 | 2024-03-01 | Buy |
| Cayman Chemical | 27319 | ML-18 | 1422269-30-4 | 10mg | $315 | 2024-03-01 | Buy |
| TRC | M425185 | ML18 | 1422269-30-4 | 1mg | $90 | 2021-12-16 | Buy |
ML 18 Chemical Properties,Uses,Production
Description
ML-18 is a non-peptide bombesin receptor subtype 3 (BB3) antagonist that inhibits [125I]BA1 binding to NCI-H1299 lung cancer cells transfected with human BB3 receptors (IC50 = 4.8 μM). It is selective for BB3 over the gastrin releasing peptide receptor (GRPR) and the neuromedin B receptor (NMBR) with IC50 values of 16 and >100 μM, respectively, in a radioligand binding assay. ML-18 (16 μM) reversibly inhibits BA1-induced increases in cytosolic calcium in NCI-H1299 cells. It also inhibits BA1-induced phosphorylation of ERK and EGFR and reduces proliferation of NCI-H1299 cells.
Uses
ML-18 is a non-peptide bombesin receptor subtype-3 antagonist. It also inhibits lung cancer growth.
ML 18 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 44)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Shanghai JiYi Biotechnology Co. Ltd. | 13621943973 | sales@shjiyipharmatech.com | China | 1166 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| Shanghai Chaolan Chemical Technology Center | QQ:65489617 15618227136 | info@SuperLan-chem.com | China | 9440 | 58 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 010-50973130 4009686088 | 3193328036@qq.com | China | 29797 | 68 |
1422269-30-4(ML 18)Related Search:
ML 18
BRS-3 antagonist
ML18;ML-18;ML 18;BRS-3 ANTAGONIST;1422269-30-4
ML18, >98%
(2S)-3-(1H-INDOL-3-YL)-N-{[1-(4-METHOXYPHENYL)CYCLOHEXYL]METHYL}-2-{[(4-NITROPHENYL)CARBAMOYL]AMINO}PROPANAMIDE
(S)-3-(1H-Indol-3-yl)-N-((1-(4-methoxyphenyl)cyclohexyl)methyl)-2-(3-(4-nitrophenyl)ureido)propanamide
Bombesin Receptor,ML-18,ML 18,inhibit,Inhibitor,ML18
1422269-30-4