ChemicalBook >> CAS DataBase List >>2,2,6,6-Tetramethylpiperidine

2,2,6,6-Tetramethylpiperidine

CAS No.
768-66-1
Chemical Name:
2,2,6,6-Tetramethylpiperidine
Synonyms
HTMP;TETRAMETHYLPIPERIDINE;2,2,6,6-TetramethyL;6-TetraMethylpiperidine;2,2,6,6-Teteamethyl-piperidine;2,2,6,6-Tetramethylpiperidine(Tmp);2,2,6;Norpempidine;2,2,6,6-Tetramethylp;2,2,6,6-Tetramethylpiperidien
CBNumber:
CB3320372
Molecular Formula:
C9H19N
Molecular Weight:
141.25
MDL Number:
MFCD00005985
MOL File:
768-66-1.mol
MSDS File:
SDS
Last updated:2023-12-18 08:54:39

2,2,6,6-Tetramethylpiperidine Properties

Melting point -59°C
Boiling point 152 °C (lit.)
Density 0.837 g/mL at 25 °C (lit.)
vapor pressure 14 hPa (39 °C)
refractive index n20/D 1.445(lit.)
Flash point 76 °F
storage temp. Store below +30°C.
solubility MISCIBLE
pka 11.07(at 25℃)
form Liquid
Specific Gravity 0.837
color Clear colorless to yellow
Water Solubility MISCIBLE
Sensitive Air Sensitive
BRN 103296
InChIKey RKMGAJGJIURJSJ-UHFFFAOYSA-N
CAS DataBase Reference 768-66-1(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 44N9S1YCFM
NIST Chemistry Reference Piperidine, 2,2,6,6-tetramethyl-(768-66-1)
EPA Substance Registry System Piperidine, 2,2,6,6-tetramethyl- (768-66-1)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
GHS02,GHS05,GHS07
Signal word  Danger
Hazard statements  H226-H290-H302-H314
Precautionary statements  P210-P233-P280-P301+P312-P303+P361+P353-P305+P351+P338
Hazard Codes  Xn,F,C
Risk Statements  10-22-36/37/38
Safety Statements  26-37/39-16
RIDADR  UN 1992 3/PG 3
WGK Germany  2
RTECS  TN4220000
Autoignition Temperature 290 °C
TSCA  Yes
HazardClass  3
PackingGroup  III
HS Code  29333999
Toxicity LD50 orally in Rabbit: 500 mg/kg
NFPA 704
3
3 0

2,2,6,6-Tetramethylpiperidine price More Price(33)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.18132 2,2,6,6-Tetramethylpiperidine for synthesis 768-66-1 25mL $114 2024-03-01 Buy
Sigma-Aldrich 115754 2,2,6,6-Tetramethylpiperidine ≥99% 768-66-1 5g $44.7 2024-03-01 Buy
Sigma-Aldrich 8.18132 2,2,6,6-Tetramethylpiperidine for synthesis 768-66-1 100mL $205 2024-03-01 Buy
Sigma-Aldrich 115754 2,2,6,6-Tetramethylpiperidine ≥99% 768-66-1 10g $84 2024-03-01 Buy
TCI Chemical T1051 2,2,6,6-Tetramethylpiperidine >98.0%(GC)(T) 768-66-1 25mL $113 2024-03-01 Buy
Product number Packaging Price Buy
8.18132 25mL $114 Buy
115754 5g $44.7 Buy
8.18132 100mL $205 Buy
115754 10g $84 Buy
T1051 25mL $113 Buy

2,2,6,6-Tetramethylpiperidine Chemical Properties,Uses,Production

Chemical Properties

clear colorless to light yellow-green liquid

Uses

2,2,6,6-Tetramethylpiperidine is a hindered base used to prepare metallo-amide bases and selective generation of silylketene acetals. It is used in the preparation of hibarimicinone, (Z)-silylketene acetal and 4-substituted quinazoline. It acts as a precursor to Lithium tetramethylpiperidide and (2,2,6,6-Tetramethylpiperidin-1-yl)oxyl radical.

Uses

2,2,6,6-Tetramethylpiperidine is used in the syntheses of HMP-Y1, Hibarimicinone and HMP-P1, tyrosine kinase inhibitors.

Uses

The lithium amide has been used to efficiently ortho deprotonate pyridine-3-carboxamides.

Preparation

Many routes for the synthesis of TMP have been reported. One method starts with a conjugate addition reaction of ammonia to phorone. The intermediate triacetone amine is then reduced in a Wolff-Kishner reaction.
Preparation of 2,2,6,6-Tetramethylpiperidine

45842-10-2
768-66-1
Synthesis of 2,2,6,6-Tetramethylpiperidine from Piperidinium, 2,2,6,6-tetramethyl-1-oxo-
Global( 465)Suppliers
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Nanjing Liskon Biological Technology Co., Ltd
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+86-0371-86658258 sales@coreychem.com China 29914 58

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View Lastest Price from 2,2,6,6-Tetramethylpiperidine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2,2,6,6-Tetramethylpiperidine pictures 2023-03-29 2,2,6,6-Tetramethylpiperidine
768-66-1
US $5.00-2.00 / KG 1KG 99% 10000kg Hebei Guanlang Biotechnology Co,.LTD
2,2,6,6-Tetramethylpiperidine pictures 2022-10-11 2,2,6,6-Tetramethylpiperidine
768-66-1
US $0.00-0.00 / KG 1KG 98% 1ton Henan Aochuang Chemical Co.,Ltd.
2,2,6,6-Tetramethylpiperidine pictures 2021-11-18 2,2,6,6-Tetramethylpiperidine
768-66-1
US $10.00 / Kg/Bag 1Kg/Bag 99% 20 Tons Hebei Zhanyao Biotechnology Co. Ltd
2,2,6,6-TETRAMETHYLPIPERIDINE 2,2,6,6-tetramethyl-piperidin Norpempidine 2,2,6,6-Tetramethylpiperidine (HTMP) 2,2,6,6-Tetramethylpiperidine, 98+% 2,2,6,6-TETRAMETHYLPIPERIDINE, 99+% 2,2,6,6-Tetramethylpiperidien Piperidine, 2,2,6,6-tetramethyl- 2,2,6,6-tetramethylpiperidine(TEMP) 2,2,6,6-Tetramethylp 2,2,6,6-TetraMethylpiperidine, 98% 10GR 2,2,6,6-TetraMethylpiperidine, 98% 25GR 2,2,6,6-TETRAMETHYLPIPERIDINE FOR SYNTHE 2,2,6,6-TetraMethylpiperidine, 97+% 2,2,6,6-Tetramethylpiperidine USP/EP/BP 2,2,6 HTMP TETRAMETHYLPIPERIDINE 6-TetraMethylpiperidine 2,2,6,6-TetramethyL 2,2,6,6-Teteamethyl-piperidine 2,2,6,6-Tetramethylpiperidine(Tmp) 2,2,6,6-TETRAMETHYLPIEPERIDINE 2,2,6,6-Tetramethyl piperdine 768-66-1 768661 C9H19N AMINE Building Blocks Organic Bases Piperidines Synthetic Reagents Heterocyclic Building Blocks Fine Chemical Industrial/Fine Chemicals Piperidines, Piperidones, Piperazines Piperidine API intermediates Organic BasesBuilding Blocks Chemical Synthesis Heterocyclic Building Blocks Piperidines Synthetic Reagents 768-66-1