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4-(Trifluoromethoxy)aniline

CAS No.
461-82-5
Chemical Name:
4-(Trifluoromethoxy)aniline
Synonyms
Riluzole Related CoMpound A;AKOS B016000;4-(TrifluoroMe;Riluzole USP RC A;TIMTEC-BB SBB001667;Riluzole Impurity 10;Trifluoromethoxyaniline;4-Trifluoroethoxyaniline;4-trifluoromethoxyaniune;4-(Trifluormethoxy)anilin
CBNumber:
CB3322028
Molecular Formula:
C7H6F3NO
Molecular Weight:
177.12
MDL Number:
MFCD00041314
MOL File:
461-82-5.mol
MSDS File:
SDS
Last updated:2024-01-22 16:43:48

4-(Trifluoromethoxy)aniline Properties

Boiling point 73-75 °C10 mm Hg(lit.)
Density 1.32 g/mL at 20 °C(lit.)
refractive index n20/D 1.463(lit.)
Flash point 177 °F
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
pka 3.75±0.10(Predicted)
form Liquid
color Clear colorless to yellow
Specific Gravity 1.310
BRN 2090209
Stability Hygroscopic
InChI InChI=1S/C7H6F3NO/c8-7(9,10)12-6-3-1-5(11)2-4-6/h1-4H,11H2
InChIKey XUJFOSLZQITUOI-UHFFFAOYSA-N
SMILES C1(N)=CC=C(OC(F)(F)F)C=C1
CAS DataBase Reference 461-82-5(CAS DataBase Reference)
FDA UNII P40L42CVF6

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
GHS05,GHS06,GHS08
Signal word  Danger
Hazard statements  H301-H310-H315-H318-H373
Precautionary statements  P260-P280-P280-P301+P330+P331+P310-P302+P352+P310-P305+P351+P338+P310
Hazard Codes  T,Xi,Xn
Risk Statements  24/25-33-38-41-36/37/38-20/21/22
Safety Statements  26-36/37/39-45-36
RIDADR  UN 2941 6.1/PG 3
WGK Germany  2
Hazard Note  Toxic
HazardClass  6.1
HazardClass  IRRITANT, TOXIC
PackingGroup  III
HS Code  29222900
NFPA 704
1
4 0

4-(Trifluoromethoxy)aniline price More Price(30)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 337056 4-(Trifluoromethoxy)aniline 98% 461-82-5 5g $46.8 2024-03-01 Buy
Sigma-Aldrich PHR3132 Riluzole Related Compound A pharmaceutical secondary standard, certified reference material 461-82-5 50MG $534 2024-03-01 Buy
Sigma-Aldrich 1604348 Riluzole Related Compound A United States Pharmacopeia (USP) Reference Standard 461-82-5 25mg $1210 2024-03-01 Buy
TCI Chemical T1345 4-(Trifluoromethoxy)aniline >98.0%(GC)(T) 461-82-5 5g $20 2024-03-01 Buy
TCI Chemical T1345 4-(Trifluoromethoxy)aniline >98.0%(GC)(T) 461-82-5 25g $55 2024-03-01 Buy
Product number Packaging Price Buy
337056 5g $46.8 Buy
PHR3132 50MG $534 Buy
1604348 25mg $1210 Buy
T1345 5g $20 Buy
T1345 25g $55 Buy

4-(Trifluoromethoxy)aniline Chemical Properties,Uses,Production

Chemical Properties

CLEAR YELLOW LIQUID

Uses

4-(Trifluoromethoxy)aniline was used in the synthesis of:

  • side-group liquid-crystalline polymethacrylates with fluorine-containing mesogens
  • derivatives of 3-(quinolin-3-yl)acrylates
  • series of novel Shiff bases, via condensation with pyridinecarboxaldehydes in the presence of molecular sieves

Uses

4-(Trifluoromethoxy)aniline is used in the synthesis of anticancer agents and antitumor medicaments. Also, its an intermediate in the production of labelled Riluzole, a neuroprotective agent. Modulates glutamatergic transmission. A glutamate release inhibitor. An anticonvulsant.

456-55-3
461-82-5
Synthesis of 4-(Trifluoromethoxy)aniline from (Trifluoromethoxy)benzene
Global( 554)Suppliers
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Qi-Chem Co., Ltd.
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ATK CHEMICAL COMPANY LIMITED
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View Lastest Price from 4-(Trifluoromethoxy)aniline manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-(Trifluoromethoxy)aniline pictures 2024-01-22 4-(Trifluoromethoxy)aniline
461-82-5
US $8.00-0.80 / KG 1KG 99% g-kg-tons, free sample is available Henan Fengda Chemical Co., Ltd
4-(Trifluoromethoxy)aniline pictures 2023-11-01 4-(Trifluoromethoxy)aniline
461-82-5
US $0.00 / KG 1KG 99% 50000KG/month Hebei Mojin Biotechnology Co., Ltd
4-(Trifluoromethoxy)aniline pictures 2023-10-10 4-(Trifluoromethoxy)aniline
461-82-5
US $20.00-7.00 / kg 1kg 0.99 30 tons Hebei Yanxi Chemical Co., Ltd.
Riluzole Related Compound A (25 mg) (4-trifluoromethoxyaniline) 4-(TrifluoroMethoxy)aniline, 99+% 2.5GR For trifluoromethoxy aniline 4- threedifluoro Methoxyaniline 4-TrifluoroMethoxyaniline, 97+% The trifluoro Methoxy aniline 4-(TrifluoroMe 4-(Trifluormethoxy)anilin 4-(TRIFLUOROMETHOXY)ANILINE 99.5+% 4-(trifluoromethoxy)aniline,2-(trifluoromethoxy)benzenamine Benzenamine, 4-(trifluoromethoxy)- 4-(Trifluoromethoxy)aniline,α,α,α-Trifluoro-p-anisidine AMino TrifluoroMethoxybenzene 4-Amino-alpha,alpha,alpha-trifluoroanisole ALPHA,ALPHA,ALPHA-TRIFLUORO-P-ANISIDINE AKOS B016000 4-(TRIFLUOROMETHOXY)ANILINE 4-TRIFLUOROMETHOXY-PHENYLAMINE TIMTEC-BB SBB001667 4-Trifluoroethoxyaniline 4-trifluoromethoxyaniune p-Trifluoromethoxyaniline p-Aminotrifluoromethoxybenzene P-Aminotrifluoromethpxybenzene 4-Aminotrifluoromethoxybenzene 4-(Trifluoromethoxy)aniline, 99+% 4-TRIFLUORO METHOXYLAMINE α,α,α-trifluoro-p-anisidine 4-(Trifluoromethoxy)aniline 98% 4-(Trifluoromethoxy)aniline98% 4-(Trifluoromethoxy)aminobenzene 4-Trifluoronethoxyaniline Riluzole USP Related Compound A Riluzole Impurity 10 4-(trifluoromethoxy)benzenaime Riluzole USP RC A Trifluoromethoxyaniline 4-(Trifluomethoxy) Aniline Riluzole Related Compound A (4-trifluoromethoxyaniline) (1604348) Riluzole Related CoMpound A 461-82-5 462-28-5 117528-59-4 C7H5F3NO CF3OC6H4NH2 Organic Building Blocks Nitrogen Compounds ARYL HALIDE AMINE Building Blocks Amines C7 Building Blocks C7 Chemical Synthesis Nitrogen Compounds Organic Building Blocks Pyridines