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4-(Trifluoromethoxy)aniline

4-(Trifluoromethoxy)aniline Structure
4-(Trifluoromethoxy)aniline structure
CAS No.
461-82-5
Chemical Name:
4-(Trifluoromethoxy)aniline
Synonyms
Riluzole Related CoMpound A;AKOS B016000;4-(TrifluoroMe;Riluzole USP RC A;TIMTEC-BB SBB001667;Riluzole Impurity 10;Trifluoromethoxyaniline;4-Trifluoroethoxyaniline;4-trifluoromethoxyaniune;4-(Trifluormethoxy)anilin
CBNumber:
CB3322028
Molecular Formula:
C7H6F3NO
Molecular Weight:
177.12
MDL Number:
MFCD00041314
MOL File:
461-82-5.mol
MSDS File:
SDS
Last updated:2025-09-25 17:15:13
Product description Number Pack Size Price
4-(Trifluoromethoxy)aniline 98% 337056 5g $48.2
Riluzole Related Compound A pharmaceutical secondary standard, certified reference material PHR3132 50MG $549
Riluzole Related Compound A United States Pharmacopeia (USP) Reference Standard 1604348 25mg $1200
4-(Trifluoromethoxy)aniline >98.0%(GC)(T) T1345 5g $20
4-(Trifluoromethoxy)aniline >98.0%(GC)(T) T1345 25g $55
More product size
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4-(Trifluoromethoxy)aniline Properties

Boiling point 73-75 °C10 mm Hg(lit.)
Density 1.32 g/mL at 20 °C(lit.)
refractive index n20/D 1.463(lit.)
Flash point 177 °F
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
pka 3.75±0.10(Predicted)
form Liquid
color Clear colorless to yellow
Specific Gravity 1.310
BRN 2090209
Stability Hygroscopic
InChI InChI=1S/C7H6F3NO/c8-7(9,10)12-6-3-1-5(11)2-4-6/h1-4H,11H2
InChIKey XUJFOSLZQITUOI-UHFFFAOYSA-N
SMILES C1(N)=CC=C(OC(F)(F)F)C=C1
CAS DataBase Reference 461-82-5(CAS DataBase Reference)
FDA UNII P40L42CVF6
UNSPSC Code 41116107
NACRES NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
GHS05,GHS06,GHS08
Signal word  Danger
Hazard statements  H301-H310-H315-H318-H373
Precautionary statements  P260-P280-P280-P301+P330+P331+P310-P302+P352+P310-P305+P351+P338+P310
Hazard Codes  T,Xi,Xn
Risk Statements  24/25-33-38-41-36/37/38-20/21/22
Safety Statements  26-36/37/39-45-36
RIDADR  UN 2941 6.1/PG 3
WGK Germany  2
Hazard Note  Toxic
HazardClass  IRRITANT, TOXIC
HazardClass  6.1
PackingGroup  III
HS Code  29222900
Limited Quantities 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)
NFPA 704
1
4 0

4-(Trifluoromethoxy)aniline price More Price(30)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 337056 4-(Trifluoromethoxy)aniline 98% 461-82-5 5g $48.2 2025-07-31 Buy
Sigma-Aldrich PHR3132 Riluzole Related Compound A pharmaceutical secondary standard, certified reference material 461-82-5 50MG $549 2025-07-31 Buy
Sigma-Aldrich 1604348 Riluzole Related Compound A United States Pharmacopeia (USP) Reference Standard 461-82-5 25mg $1200 2025-07-31 Buy
TCI Chemical T1345 4-(Trifluoromethoxy)aniline >98.0%(GC)(T) 461-82-5 5g $20 2025-07-31 Buy
TCI Chemical T1345 4-(Trifluoromethoxy)aniline >98.0%(GC)(T) 461-82-5 25g $55 2025-07-31 Buy
Product number Packaging Price Buy
337056 5g $48.2 Buy
PHR3132 50MG $549 Buy
1604348 25mg $1200 Buy
T1345 5g $20 Buy
T1345 25g $55 Buy

4-(Trifluoromethoxy)aniline Chemical Properties,Uses,Production

Chemical Properties

CLEAR YELLOW LIQUID

Uses

4-(Trifluoromethoxy)aniline was used in the synthesis of:

  • side-group liquid-crystalline polymethacrylates with fluorine-containing mesogens
  • derivatives of 3-(quinolin-3-yl)acrylates
  • series of novel Shiff bases, via condensation with pyridinecarboxaldehydes in the presence of molecular sieves

Uses

4-(Trifluoromethoxy)aniline is used in the synthesis of anticancer agents and antitumor medicaments. Also, its an intermediate in the production of labelled Riluzole, a neuroprotective agent. Modulates glutamatergic transmission. A glutamate release inhibitor. An anticonvulsant.

Synthesis

1-Bromo-4-(trifluoromethoxy)benzene

407-14-7

4-(Trifluoromethoxy)aniline

461-82-5

General procedure: To a flame-dried 25 mL round-bottom flask were added activated magnesium chips (7.5 mmol, 1.5 eq.) and 5 mL of anhydrous tetrahydrofuran (THF). Two drops of 1,2-dibromoethane were added to the suspension to initiate the reaction. 5 min later, a solution of p-bromotrifluoromethoxybenzene (5 mmol, 1.0 eq.) dissolved in 5 mL of anhydrous THF was slowly added to the magnesium suspension at room temperature. A mild exothermic phenomenon was observed during the reaction. After determining the concentration of Grignard's reagent by titration, 1 mmol of the reagent was transferred to another flame-dried reaction flask. The solution was diluted with 3 mL of anhydrous toluene and after cooling to the preset temperature T, a solution of oxazepane (1.2 mmol, 1.2 equiv) dissolved in 1 mL of anhydrous toluene was added. The reaction mixture was held at temperature T for a reaction time t, followed by quenching the reaction with saturated aqueous ammonium chloride (NH4Cl). (Specific reaction temperatures and reaction times need to be listed according to the actual conditions of each substrate.)

References

[1] Organic Letters, 2013, vol. 15, # 14, p. 3734 - 3737
[2] Nature Chemistry, 2017, vol. 9, # 7, p. 681 - 688
[3] Patent: US2018/57444, 2018, A1. Location in patent: Paragraph 0098; 0134; 0135; 0171

4-(Trifluoromethoxy)aniline synthesis

456-55-3
461-82-5
Synthesis of 4-(Trifluoromethoxy)aniline from (Trifluoromethoxy)benzene

4-(Trifluoromethoxy)aniline Preparation Products And Raw materials

Raw materials

4-(TRIFLUOROMETHOXY)BENZAMIDE 4-(Trifluoromethoxy)nitrobenzene Potassium hydroxide 1-azido-4-(trifluoromethoxy)benzene N-METHYL-4-(TRIFLUOROMETHOXY)ANILINE
1-Bromo-4-(trifluoromethoxy)benzene (trichloromethoxy)benzene 4-(Trifluoromethoxy)benzonitrile (Trifluoromethoxy)benzene Trifluoromethane

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Preparation Products

Triflumuron Riluzole 5-[4-(TRIFLUOROMETHOXY)PHENYL]-2-FURALDEHYDE 1-Iado-4-(trifluoromethoxy)benzene 3-(Trifluoromethoxy)bromobenzene
2-Nitro-4-(trifluoromethoxy)aniline 1-(4-(TRIFLUOROMETHOXY)PHENYL)-3-BENZOYLTHIOUREA Benzene, 1-isocyano-4-(trifluoromethoxy)- (9CI) 2-Methyl-6-trifluoromethoxyquinolin-4-ol

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4-(Trifluoromethoxy)aniline Suppliers

Global( 587)Suppliers
Supplier Tel Email Country ProdList Advantage
Qi-Chem Co., Ltd. 		+86-15633578820 +86-13591335396 chris.wang@qi-chem.com China 133 58
Hebei Chuanghai Biotechnology Co., Ltd 		+8615350571055 Sibel@chuanghaibio.com China 8770 58
Sichuan Zhuoyu Yantang Technology Co., Ltd. 		+8613288715578 sales@sichuanzyyt.com China 12242 58
Hebei Yanxi Chemical Co., Ltd. 		+8618531123677 faithe@yan-xi.com China 5853 58
Hebei Chuanghai Biotechnology Co,.LTD 		+86-13131129325 sales1@chuanghaibio.com China 5251 58
Hebei Chuanghai Biotechnology Co., Ltd 		+8615531151365 mina@chuanghaibio.com China 18126 58
Anhui Ruihan Technology Co., Ltd 		+8617756083858 daisy@anhuiruihan.com China 973 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20173 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29735 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-2158073036 info@dakenam.com China 13505 58
Supplier Advantage
Qi-Chem Co., Ltd. 		58
Hebei Chuanghai Biotechnology Co., Ltd 		58
Sichuan Zhuoyu Yantang Technology Co., Ltd. 		58
Hebei Yanxi Chemical Co., Ltd. 		58
Hebei Chuanghai Biotechnology Co,.LTD 		58
Hebei Chuanghai Biotechnology Co., Ltd 		58
Anhui Ruihan Technology Co., Ltd 		58
Henan Fengda Chemical Co., Ltd 		58
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58

Related articles

View Lastest Price from 4-(Trifluoromethoxy)aniline manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-(Trifluoromethoxy)aniline pictures 2025-11-06 4-(Trifluoromethoxy)aniline
461-82-5
 US $0.00 / KG 1KG 99% 10 mt Hebei Chuanghai Biotechnology Co., Ltd
4-(Trifluoromethoxy)aniline pictures 2025-09-25 4-(Trifluoromethoxy)aniline
461-82-5
 US $8.00-0.80 / KG 1KG 99% g-kg-tons, free sample is available Henan Fengda Chemical Co., Ltd
4-(Trifluoromethoxy)aniline pictures 2025-08-08 4-(Trifluoromethoxy)aniline
461-82-5
 US $0.00 / KG 1KG 99% 50000KG/month Sichuan Zhuoyu Yantang Technology Co., Ltd.

4-(Trifluoromethoxy)aniline Spectrum

4-(Trifluoromethoxy)aniline(461-82-5)MS4-(Trifluoromethoxy)aniline(461-82-5)1HNMR4-(Trifluoromethoxy)aniline(461-82-5)13CNMR4-(Trifluoromethoxy)aniline(461-82-5)IR14-(Trifluoromethoxy)aniline(461-82-5)Raman

461-82-5(4-(Trifluoromethoxy)aniline)Related Search:

4-Methoxyphenylacetic acid 4-Methoxybenzylchloride p-Trifluoromethoxy phenol 3-(Trifluoromethoxy)aniline Trimethyl phosphite
2-Fluoroaniline Aniline 3-Methoxybenzaldehyde (Trifluoromethoxy)benzene Anisole
o-Anisaldehyde 4'-(Trifluoromethoxy)acetophenone 4-Methoxyphenylacetone (3-Methoxyphenyl)acetonitrile 4-Aminobenzotrifluoride
2-(Trifluoromethoxy)aniline 4-(Trifluoromethoxy)chlorobenzene 4-Fluoroaniline

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Riluzole Related Compound A (25 mg) (4-trifluoromethoxyaniline) 4-(TrifluoroMethoxy)aniline, 99+% 2.5GR For trifluoromethoxy aniline 4- threedifluoro Methoxyaniline 4-TrifluoroMethoxyaniline, 97+% The trifluoro Methoxy aniline 4-(TrifluoroMe 4-(Trifluormethoxy)anilin 4-(TRIFLUOROMETHOXY)ANILINE 99.5+% 4-(trifluoromethoxy)aniline,2-(trifluoromethoxy)benzenamine Benzenamine, 4-(trifluoromethoxy)- 4-(Trifluoromethoxy)aniline,α,α,α-Trifluoro-p-anisidine AMino TrifluoroMethoxybenzene 4-Amino-alpha,alpha,alpha-trifluoroanisole ALPHA,ALPHA,ALPHA-TRIFLUORO-P-ANISIDINE AKOS B016000 4-(TRIFLUOROMETHOXY)ANILINE 4-TRIFLUOROMETHOXY-PHENYLAMINE TIMTEC-BB SBB001667 4-Trifluoroethoxyaniline 4-trifluoromethoxyaniune p-Trifluoromethoxyaniline p-Aminotrifluoromethoxybenzene P-Aminotrifluoromethpxybenzene 4-Aminotrifluoromethoxybenzene 4-(Trifluoromethoxy)aniline, 99+% 4-TRIFLUORO METHOXYLAMINE α,α,α-trifluoro-p-anisidine 4-(Trifluoromethoxy)aniline 98% 4-(Trifluoromethoxy)aniline98% 4-(Trifluoromethoxy)aminobenzene 4-Trifluoronethoxyaniline Riluzole USP Related Compound A Riluzole Impurity 10 4-(trifluoromethoxy)benzenaime Riluzole USP RC A Trifluoromethoxyaniline 4-(Trifluomethoxy) Aniline Riluzole Related Compound A (4-trifluoromethoxyaniline) (1604348) Riluzole Related CoMpound A 2-Nitro-4-Chlorotrifluoromethoxybenzene 461-82-5 462-28-5 117528-59-4 C7H5F3NO CF3OC6H4NH2 Organic Building Blocks Nitrogen Compounds ARYL HALIDE AMINE Building Blocks Amines C7 Building Blocks C7 Chemical Synthesis Nitrogen Compounds Organic Building Blocks